ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
who were sequentially admitted to the
intensive care unit. We used weaning of
mechanical ventilation during the 28-day
period as the endpoints. The follow-up
of patients were performed until when
the patient weaned <strong>from</strong> mechanical
ventilation for the first time or the
patient died during the 28-day period.
After clinical data were obtained, the
patients were underwent mtDNA
haplotyping. We determined the mtDNA
haplpgroups by comprehensive
analyzing to the sequences of mtDNA
hypervariable segment Ⅰ(HVSⅠ) and
haplotyping specific polymorphisms in
the mtDNA coding region. Results:
Auunivariate analysis indicated that
weaning individuals were significantly
different <strong>from</strong> non-weaning ones <strong>from</strong>
some demographic and clinical
characteristics, including younger age,
lower APACHEⅡ and SOFA score, less
likely to have chronic ill health. On
admission to intensive care unit, the
frequency of the main subhaplogroups of
Han population in the study cohort did
not differ significantly <strong>from</strong> the control
group. Kaplan-Meier analysis showed
significantly higher mechanical
ventilation weaning rate over 28 days in
patients with mtDNA haplogroup R than
those without the haplogroup (p=0.042).
Binary logistic regression analysis
indicated mtDNA haplogroup R was an
independent predictor of mechanical
ventilation weaning, cofferring 4.038-
fold (p=0.007) increased chance of
mechanical ventilation weaning at 28
days compared with those without the
haplogroup. Conclusion: In Han
population, mtDNA haplogroup R was
an independent predictor for the weaning
<strong>from</strong> mechanical ventilation of critically
ill patients, conferring increased chance
of weaning rate compared with
individuals without the haplogroup.
TECHNIQUE CHARACTERISTICS
59. A Comparison of Filter Patency in
CVVHD vs pre–dilutional CVVH
in High Blood Flow CRRT
Systems
Gaurav Agarwal, Anna M Brunson,
Brad C Astor, A Djamali, R M
HofmannDepartment of Medicine,
University of Wisconsin School of
Medicine and Public Health. Division of
Nephrology. Madison, WI, USA , Acute
Dialysis Services, University of
Wisconsin Hospitals and Clinics,
Madison WI, US
Background: It is unknown if pre-filter
replacement fluids decrease clotting
versus diffusive therapies due to
hemodilution effect in high blood flow
continuous renal replacement (CRRT)
era. National shortages of calcium
injectables forced us to abandon regional
citrate anticoagulation for CRRT. We
wanted to determine if predilution
continuous venovenous hemofiltration
(CVVH) offered an advantage over
continuous venovenous hemodialysis
(CVVHD) for filter patency.
Methods- We gathered data pertaining to
all patients who received CRRT without
any anticoagulation in the last 8 months.
We compared filter life in the 2 groups –
CVVH with pre dilution replacement
fluid (group 1) vs CVVHD (group 2).
All patients were run on the NxStage
system one with a blood flow of 25
ml/min. 2 ml saline flushes were
administered hourly to evaluate for filter
patency. In group one, replacement
fluids were started at 3 liters/hr and
adjusted clinically. In group 2, dialysate
was run at 25 ml/kg/hr and adjusted
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