ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
62. Treatment of hyperlipidemia in
resistant nephrotic syndrome: the
effect of combined therapy using
double filtration plasmapheresis
and oral statins
Dehua Gong, Daxi Ji, Dongdong Zhu,
Lihua Zhang, Bin Xu, Zhihong Liu
Research Institute of Nephrology
Objective: by a case-controlled design,
to compare the effects of treatment on
hyperlipidemia in resistant nephrotic
syndrome by combined therapy using
double filtration plasmapheresis(DFPP)
and oral statins or oral statins only.
Methods: Eight inpatients were enrolled
and received 1 session of DFPP for
severe hyperlipidemia due to resistant
nephrotic syndrome(NS). Oral
Atorvastatin(2mg/d) were continuously
given to these patients 1 week prior to
start of DFPP until the end of
followup(Combination group). In the
same period 12 outpatients with severe
hyperlididemia due to resistant NS were
enrolled to take oral Atorvastatin
(2mg/d)( statins group). In addition to
treatment of hyperlipidemia, standard
cares for primary renal disease were also
given to all patients. For 1-month
follow-up period, the changes of plasma
concentration of lipids and albumin as
well as urinary proteins were monitored.
Results: There were no significant
changes of serum albumin concentration
and urinary proteins after 1 month in
both groups. In the combination group,
baseline values for serum albumin, total
cholesterol, triglycerides, LDL-C and
fibrogen were 18.7±5.g/L, 15.2±7.4
mmol/L, 5.5±5.21mmol/L,
9.±4.2mmol/L and 426±5mg/L,
respectively. The reduction rate after
single session of DFPP for these
parameters were -11.3±13.4, 85.8±7.2,
8.1±6.2, 86.9±11.4, and 54.7±14.3%,
respectively. At 2 weeks and 4 weeks
after DFPP, the concentrations of plasma
total cholesterol were as 41.8±13.4%
and 7.2±21.% of baseline, while the
concentration of triglycerides were as
68.6±45.5% and 125.8±48.8% of
baseline. In the statins group, the
baseline value of plasma albumin, total
cholesterol and triglycerides were
23.6±3.9g/L, 15.4±5.mmol/L and
5.2±3.3mmol/L, respectively. At 2
weeks and 4 weeks follow-up, the
concentrations of plasma total
cholesterol were as 81.2±21.1% and
81.±16.7% of baseline, while the
concentration of triglycerides were as
85.3±43.1% and 18.4±55.6% of
baseline. The difference of plasma total
cholesterol levels between two groups at
the 2 weeks follow-up was significant
(P