ABSTRACTS from 16th International COnference on ... - CRRT Online

D04
Biomarkers 1: Principles and Applications
Educational Objectives:
1. Highlight that biomarker performance is modified by context and cause
2. Discuss the use of phase specific biomarkers to triage to treatment
Zoltan Endre MD, PhD
4:00-5:30
Tuesday, February 14
Content Description:
The EARLYARF trial was the first to utilize urinary biomarkers to triage patients to an intervention. The intervention
(high dose erythropoietin) did not modify outcome, despite randomizing patients to treatment within 6
hours of entry to the intensive care unit. Possible reasons for lack of success include failing to commence therapy
within 6 hours of onset of injury and inadequate enrichment with AKI patients because of the brief profile of the
specific pre-formed biomarker (a combination of gammaglutamyl transpeptidase and alkaline phosphatase).
The trial will be used to highlight problems with current randomized controlled trial design and in particular to
illustrate how biomarker performance varies with etiology of AKI, duration of AKI, baseline GFR (before
injury), severity and duration of AKI and stage and phase of AKI.
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