ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
lowest quartile, Δ< -22ng/ml), and the
stable/persistent group (Δ was within
IQR). In the stable/persistent group,
urinary NGAL of day 1, day 2, their
average, maximum and minimum values
were all significantly associated with
worsening kidney function (AUC-ROC
> .9). On the other hand, only urinary
NGAL at day 1, minimum values
showed significant associations in the
increasing group (AUC-ROC .75). In the
decreasing group, urinary NGAL failed
to show any significant association with
worsening of AKI. However, relative
reduction rate was able to predict
recovery <strong>from</strong> AKI (AUC-ROC=.72).
Conclusion: In the present study,
absolute values of urinary NGAL can
predict worsening AKI when increased
or stable within 24 hr after ICU
admission. Relative reduction rate can be
used to predict recovery <strong>from</strong> AKI when
urinary NGAL decreased after ICU
admission. These data indicate serial
measurement of urinary NGAL is useful
for predicting AKI worsening and
recovery
46. Transfusion Related Acute Kidney
Injury: Result of a Prospective
Cohort Study
Ladan Zand, Rodrigo Cartin-Ceba,
Kianoush Kashani
Mayo Clinic, Rochester, MN
Background: Acute kidney injury (AKI)
occurs in up to two third of intensive
care unit (ICU) patients. It has been
shown that blood product transfusion
increases risk of acute lung injury
(TRALI). Considering strong association
between ALI and AKI, we evaluated the
association between transfusion and AKI
in ICU patients. Methods: We
performed a retrospective analysis of a
prospectively collected cohort of
consecutive adults (>18 years of age)
who were admitted to the ICU and
received blood product transfusion <strong>from</strong>
March 24 to December 25. We excluded
those who developed AKI prior to
receiving transfusion or who were on
chronic hemodialysis at time of
admission. Results: A total of 127
patients met the inclusion criteria. The
median age was 64 (IQR, 53-77), 65
were male (51%). A total of 49 (38%)
patients developed AKI based on the
AKIN criteria. In univariate analysis,
there was no statistical significant
difference in development of AKI based
on the type of blood product that the
patients received (cryoprecipitate,
packed red blood cells, platelets or fresh
frozen plasma). After adjustment for
age, gender, baseline creatinine and
presence of shock upon ICU admission,
the transfusion of blood products was
not independently associated with
development of AKI (Odds ratio 1.6,
95% CI .95-1.18, p=.25). Conclusion:
In a cohort of heterogenous group of
ICU patient who received blood product
transfusion, there was no increased risk
of AKI.
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