ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
antivirals (OR 1.24,95% CI 1.11-1.39)
were significantly associated with higher
risk for AKI, while ACE-inhibitors (OR
.88,95%CI .84-.92), aspirin (OR
.74,95%CI .7-.77), non-steroidal antiinflammatory
drugs (NSAIDs) (OR .91,
95%CI .81-.96) and statins (OR .79,
95%CI .75-.84) were associated with
lower risk. In addition, use of
amphotericin B (OR 1.71, 95%CI 1.31-
2.24), diuretics (OR 1.53, 95%CI 1.35-
1.74), vasopressors (OR 1.75, 95%CI
1.54-1.98) and beta-blockers (OR 1.18,
95%CI 1.4-1.35) was associated with
increased risk for partial or no renal
recovery in patients who developed
postoperative AKI.
Conclusion: Our findings demonstrate
that several commonly used
postoperative medications may be
associated not only with increased risk
for AKI but also decrease the likelihood
of renal recovery after AKI episode.
49. Retrospective Analysis Of Acute
Kidney Injury In Non Renal Solid
Organ Transplant Recipients:
Incidence, Outcome And Impact
On Residual Renal Function
Vincenzo Cantaluppi, Alessandro D
Quercia, Dario Montermini, Sergio
Dellepiane, Alfonso Pacitti, Giuseppe P
Segoloni
University of Turin, San Giovanni
Battista Molinette Hospital, P.G.M.D.
Consulting Inc., Milan, Italy,
Nephrology and Dialysis Unit, S.S.
Croce e Carle Hospital, Cuneo, Italy
Acute kidney injury (AKI) is a frequent
complication in critically ill patients that
is often associated with high mortality
rates. Despite the increased incidence of
chronic kidney disease (CKD) in non
renal solid organ transplant (NRSOT)
recipients due to drug nephrotoxicity,
only a few studies analyzed the clinical
impact of AKI in this selected
population.
The aim of the present study was a 10-
year retrospective analysis of AKI
incidence in NRSOT recipients to
identify its impact on outcome and
progression toward CKD.
We retrospectively analyzed (2001-
2010) the %age of NRSOT in the whole
AKI population treated by dialysis. For
each NRSOT recipient, we evaluated
RIFLE and SOFA scores and the
severity index ATN_ISS at the start of
dialysis. The %age of AKI requiring
dialysis in the whole NRSOT population
and for single transplanted organ (liver,
heart or lung graft) was also studied.
Renal function was evaluated at the end
of observation (30 days). Hemer-
Lemeshow statistical test was
performed.
In the period 2001-2010, we treated by
dialysis (sustained slow hemofiltration
of 10-12 hr, pre-dilution fluid 30-50%,
blood flow 200 ml/min, polysulphone
membranes 1.4-1.8mq) 1833 critically ill
patients with AKI for a total of 9061
sessions. Among this population,
233/1833 (12.7%) were NRSOT
recipients. We treated by dialysis
151/1335 (11.3 %) patients with a liver
graft, 60/229 (26.2 %) with a heart graft
and 22/88 (25%) with a lung graft.
NRSOT patients’ characteristics were:
mean age 58.4 yrs (SD 8.2), male 66.6%,
mean serum creatinine 3.46 mg% (SD
1.34), mean number of organ failures 3.3
(SD 1.87) and mean ATN_ISS score
0.63 (SD 0.13). The prevalent cause of
AKI in NRSOT patients was sepsis
(43.6%), associated with high mortality
and with a difficult management of the
immunosuppressive therapy. The global
mortality in NRSOT patients was
45.49% (106/233), 43.5% (66/151) for
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