ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
65. A comparison of estimated
Creatinine clearance and
measured glomerular filtration
rate (Tc99mDTPA clearance) in
Indians
Rishi Nigam, Mukul Mathur
Indian Red Cross Hospital ,
Bhopal,India, Jawaharlal Nehru Cancer
Hospital,Bhopal
Background: The aim of this study was
to compare measured glomerular
filtration rate (GFR) with estimates of
GFR derived <strong>from</strong> various estimated
creatinine clearance methods of Jelliffe,
Cockcroft and Gault, and 4MDRD
equations in Indian population.
Methods: We enrolled 8 patients in the
study. GFR was determined by
technetium-99m diethyl triamine pentaacetic
acid (Tc99mDTPA) clearance .
Height, body weight and serum
creatinine were measured, and GFR and
creatinine clearance (CrCl) estimates
calculated by various equations.
Spearemans correlation was used to
assess relationships between measured
GFR (Tc99mDTPA clearance) and
estimated clearances using the three
formulae. Difference between the
measured GFR and estimated clearances
compared with measured GFR were
examined to determine whether
prediction error was independent <strong>from</strong>
measurement magnitude. Analyses of
differences were used to determine bias
and precision. Bias was assessed by
mean %age error (MPE), calculated as
the %age difference between the
estimated clearances for each formula
and measured GFR. A positive bias
indicates overestimation of GFR, and a
negative bias indicates underestimation.
Relationships were also assessed by
gender and varying levels of renal
function: GFR 6
ml/ min.
Results : The mean measured GFR was
77.2 ml / min (range 17 to 152 ml / min).
The mean bias (mean %age error) was -
4.9, -1.3 and -1.57% respectively for the,
Jelliffe , Cockcroft and Gault, and
4MDRD formulas, respectively. The 4
MDRD formula overestimates the GFR
in patients having GFR less than 6ml/
min, where as underestimates for GFR
more than 6ml / min. Conclusions: 4
MDRD equation seems to be best for
estimating GFR in Indian population.
66. First Intention Continuous Venovenous
Hemodiafiltration in
Young Children With Hemolytic
and Uremic Syndrome.
Paul Nolent, Julie Guichoux, Veronica
Rougeon, Jerome Harambat, Olivier
Brissaud
Children's Hospital, Bordeaux, France
Background and objectives: Hemolytic
and uremic syndrome (HUS) can lead to
acute kidney injury requiring renal
replacement therapy. Usual
recommendations favour peritoneal
dialysis (PD) in first intention for young
children (without contra indication). We
report a series of young patients with
HUS treated with continuous venovenous
hemodiafiltration (CVVHDF) in
first intention despite the lack of contra
indications for PD.
Methods: Prospective study of
consecutive cases of young children with
typical HUS treated with CVVHDF in
first intention in a single paediatric
intensive care unit (PICU) in 211.
Results: Five children aged 66, 24, 18,
17 and 13 months and weighing 23., 9.7,
11.9, 11.8 and 9.2 kg, respectively, were
included. Vascular access was in the
right internal jugular vein in 4 and in the
right sub-clavian vein in 1 patient.
Catheters used were double- lumen 8.5
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