ABSTRACTS from 16th International COnference on ... - CRRT Online

Avoiding Anticoagulation for CRRT: An Update on Emerging Membranes
Patrick M. Honoré MD
5:45-6:00
Thursday, February 16
Educational Objectives:
1)To show the great capabilities of New Membranes that are already on the Market.
2)Show the potential advantages but also the limitations of these new membranes.
3)Discuss the available literature regarding these most recent data about these new membranes.
Content Description:
Types of New Available Membranes in 2011:
New High Cut-Off Membranes:
Eg: Membranes exhibiting large pores such as SepteX® <strong>from</strong> Gambro & others..
New Adsoprtive Membranes:
Eg: Special focus on new membranes that could be run without anticoagulation.
Summary
These new membranes where heparin has been grafted instead of adsorbed or soaked do exhibit a much higher
ability to extend their filter life in the absence of any form of anticoagulation.
We will review the available membranes and data regarding this very important issue.
Suggested Reading:
1. Matson J R, Zydney AR, Honore,PM. Blood Filtration: New Opportunities and the Implications On System
Biology.Critical Care and Resucitation 2004; 6:209-218.
2. Morgera S, Haase M, Kuss T, et al. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine
in septic patients with acute renal failure. Crit Care Med 2006;34:2099-104.
3. Honoré PM, Zydney LA, Matson JR : High volume and high permeability
haemofiltration for sepsis : the evidence and the key issues. Review article.
Care of Critically ill 2003;19:69-76.
4. Cruz DN, Antonelli M, Fumagalli R, et al. Early use of polymyxin B hemoperfusion in
abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 2009;301:2445-52.
5. Honore PM, Joannes-Boyau O, Dobbeleir N.Blood Purification in Sepsis & Acute Kidney Injury in Critically
Ill Patients:New Insights & Potential Mechanisms with an Update on Recent Trials.Chapter of the Yearly Book
in Intensive Care Medicine 2011
(31 th ISICEM March 2011)
6.Honore PM et al. Continuous Hemofiltration or Intermittent Dialysis for Septic Shock Patients in ICU with
AKI :A Pragmatic Approach for Bedside Intensivists Summarizing the More Recent Advances.Annals of
Intensive Care 2011: 26.
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