ABSTRACTS from 16th International COnference on ... - CRRT Online

<strong>ABSTRACTS</strong> FROM 17 TH INTERNATIONAL CONFERENCE ON CRRT,
SAN DIEGO, FEB 14-17, 2012
Results: The Kidney Intervention
During Extracorporeal Membrane
Oxygenation (KIDMO) study group has
been formed with 6 participating
institutions (Cincinnati Children's
Hospital, Vanderbilt University, McGill
University Health Centre, University of
Alabama, University of Michigan, and
Children’s Healthcare of Atlanta). The
KIDMO centers perform a combined 2-
25 cases of ECMO per year, which will
allow for adequate recruitment for future
studies. Initial work includes a survey of
participating ECMO centers to describe
the use of CRRT in ECMO patients.
Additionally, the KIDMO group has
altered the data collection forms for the
Extracorporeal Life Support
Organization Registry, which captures
data <strong>from</strong> the worldwide ECMO
population. These alterations will
enhance data collection regarding acute
kidney injury and renal support therapies
during ECMO. Conclusions: We
describe the formation of the KIDMO
study group that leverages an
international, multi-disciplinary, multicenter
organization to provide the
patients and expertise necessary to study
AKI, FO, and CRRT in pediatric ECMO
patients. Initially, we aim to
retrospectively describe these entities to
provide the framework for development
of prospective studies to investigate
novel markers of AKI, fluid
management strategies, and
interventions to ameliorate the effects of
AKI, and optimize RST for ECMO
patients.
44. Acute Kidney Injury in
Asphyxiated Newborns Treated
with Therapeutic Hypothermia
David T Selewski, Brian Jordan, Ronald
E Dechert, Subrata Sarkar
Department of Pediatrics &
Communicable Diseases, Division of
Nephrology, C.S. Mott Children's
Hospital, University of Michigan, Ann
Arbor, MI, USA, Department of
Pediatrics & Communicable Diseases,
C.S. Mott Children's Hospital,
University of Michigan, Ann Arbor, MI,
USA, Department of Pediatrics &
Communicable Diseases, Division of
Neonatal-Perinatal Medicine, C.S. Mott
Children's Hospital, University of
Michigan, Ann Arbor, MI, USA
Background: Therapeutic hypothermia
has become the standard of care for
asphyxiated newborns. Previous reports
have described the incidence of Acute
Kidney Injury (AKI) in asphyxiated
newborns to be as high as 6% prior to
regular use of therapeutic hypothermia.
To date there has not been an evaluation
of AKI during therapeutic hypothermia
in these patients utilizing the Acute
Kidney Injury Network (AKIN) criteria
and the association of AKI with
outcome. We hypothesized AKI in
asphyxiated newborns would be
associated with increased mortality,
prolonged intensive care unit stay, and
prolonged requirement for mechanical
ventilation despite hypothermia
treatment.
Design/Methods: 96 consecutively
cooled infants were retrospectively
reviewed. All infants had renal function
assessed before the start of cooling
(baseline); at 24, 48, and 72h through
cooling; and then on day 5, 7, and 1 of
life as clinically indicated. The AKIN
criteria were used to classify AKI.
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