NASA Scientific and Technical Aerospace Reports

The current document provides information on the development of WW-85, an ultrapotent catalytic anti-oxidant as a
radioprotectant countermeasure. Radiation injury induces the generation of multiple reactive oxygen and nitrogen radicals in
living tissues which then trigger oxidative peroxidative nitrosative and other forms of damage to proteins lipids and nucleic
acids in the cells. Data in the literature indicate that neutralization of these oxidant and free radical reactions and chain
reactions is of protective value during radiation injury. However, the practical hurdles that hamper the introduction of a
clinically useful anti-oxidant are that most available anti-oxidants (such as Vitamin C Vitamin E thiol-based compounds) are
relatively slow reacting and do not neutralize fast-reacting species. In addition, effective concentrations of these compounds
are difficult to be reached in living tissues. Preclinical data with radioprotectant anti-oxidants (amifostine melatonin)
demonstrate a relatively modest effect.
DTIC
Antioxidants; Radiation Injuries
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AEROSPACE MEDICINE
Includes the biological and physiological effects of atmospheric and space flight (weightlessness, space radiation, acceleration, and
altitude stress) on the human being; and the prevention of adverse effects on those environments. For psychological and behavioral
effects of aerospace environments, see 53 Behavioral Sciences. For the effects of space on animals and plants see 51 Life Sciences.
20060001234 Institute of Space Medico-Engineering, Beijing, China
Space Medicine & Medical Engineering
Wei, Jin-He, Editor; Chen, Shan-Guang, Editor; Su, Shuang-Ning, Editor; Jian, Shu-Zhong, Editor; Wang, Xian-Min, Editor;
Liu, Xin-Min, Editor; Su, Hong-Yu, Editor; Bai, Jing, Editor; Sun, Xi-Qing, Editor; Ma, Ai-Jun, Editor, et al.; October 2005;
ISSN 1002-0837; 82 pp.; In English; See also 20060001235 - 20060001245; Copyright; Avail.: Other Sources
Topics discussed include: Effects of Tail Suspension on Phosphorylation Status of ERK1/2 in Rat Soleus Muscle;
Hemispheric Asymmetry for Encoding Unrelated Word Pairs? A Functional Near-infrared Spectroscopy Study; Effects of
Simulated Microgravity on Morphology of Human Umbilical Vein Endothelial Cells and Its Production of NO; Effects of K
+ Channel Alteration on Fatigability of High-frequency Tetanic Contraction in Mouse Atrophic Soleus; Application of
Multislice Spiral CT(MSCT) in Studies of Multi-organ Injury under + Gx in Rhesus Monkey; Biodestructive Capability of
Several Microorganisms on Space Structural Materials in Space; Comparison Study of Impact Response Characteristics
between SZM510 Dummy and Hybrid III Dummy; Experimental Study of Special Long-effect Controlled-releasing Fertilizers
in Controlled Ecological Life Support System; A3-2 Continuous Free-flow Electrophoresis Device for Separation of Model
Proteins; Feasibility Study of Mental Fatigue Grade Based on Kolmogorov Entropy; and Progress in Research of Vascular
Contractility under Weightlessness or Simulated Weightlessness.
Derived from text
Aerospace Medicine; Cardiovascular System; Life Support Systems; Mice; Muscles; Proteins; Rats; Weightlessness; Monkeys
20060001235 Chinese Academy of Sciences, Beijing, China, Institute of Space Medico-Engineering, Beijing, China
A3-2 Continuous Free-flow Electrophoresis Device for Separation of Model Proteins
Wu, Han-ji; Jiang, Yuan-da; Liu, Wen-xi; Zhang, Zhi-yuan; Feng, Xue-zhang; Xia, Qi-chang; Ding, Shi-jian; Wu, Gao-de; Li,
Qin; Space Medicine & Medical Engineering; October 2005, pp. 355-359; In English; See also 20060001234; Copyright;
Avail.: Other Sources
The objective is to study the influence of space microgravity environment on the electrophoresis separation process and
to qualify the design and technologies of A3-2 device. A3-2 device was flown on board the recoverable capsule of Shenzhou
-IV spacecraft and the electrophoretic separating experiments of the model proteins, Bovine Hemoglobin and Cytochrome C
were performed. All of the engineering and scientific parameters in the experiment were obtained. Everything in the recovered
electrophoresis unit was fine and 30 fractions were got completely after landing. Both of the results obtained by on-line LED
detector and SP22 UV spectrophotometer from the separated products, showed that the separation quality of proteins by the
continuous free-flow electrophoresis device was better under microgravity than on the ground. The A3-2 device can work well
in space. It ensures the success of space electrophoresis separating experiment for the first time in China.
Author (revised)
Electrophoresis; Free Flow; Microgravity; Proteins
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