Medical Hydrology and Balneology: Environmental Aspects

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Heat-shock protein 70 is affected by thermal treatment Scapagnni G (1) , Davinelli S (1) , Sapere N (1) , Zella D (2) , Fortunati N (3) (1) Department of Health Sciences. Faculty of Medicine and Surgery. University of Molise. Italy (2) Department of Biochemistry and Molecular Biology. Institute of Human Virology-School of Medicine. University of Maryland. Baltimore. USA (3) Grotta Giusti Spa. Monsummano terme. Italy g.scapagnini@gmail.com Introduction and Objectives Hormesis is defined as a biphasic dose-response and it may be graphically represented by either an inverted U-shaped dose response or by a J- or U-shaped dose response. Hormesis-stimulating factors initiate an adaptive stress response that renders cells/organisms resistant against high doses of the same agent. Therefore, also the exposure to a mild stressor confers resistance to subsequent conditions of increased stress. Moreover, even though not all mechanisms of hormesis are understood an emerging concept is that the effectiveness of an adaptive (hormetic) response elicits general protective and reparative mechanisms. After heat shock or other metabolic stress, heat-shock proteins (HSPs) are expressed at high levels in all tissues and cells. Abundant evidence shows that these proteins have pro-survival functions that include chaperone, anti-apoptotic and/or anti-inflammatory activity. Noteworthy, HSPs are known as important endogenous cell-protective proteins induced in response to a wide variety of stresses. Taking into account that the correlation between thermal treatment and HSP-70 has not been demonstrated, this study clarified the potential effects of this treatment on HSP-70 levels. In addition to explore whether different thermal treatments such as thermal steam bath in the natural grotta and thermal mud induce changes in individual levels of HSP-70, we have considered and investigated several parameters including C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), fibrinogen, insuline-like growth factor-1 (IGF-1). Specifically, we assessed the relationship between these parameters and the changes observed for HSP-70. Materials and Methods 20 healthy subjects over 45 years of age were enrolled into the study. Blood samples were collected after two hours from the first treatments session and after one week of treatments repeated one time a day. Study parameters including CRP, ACTH, IGF-1, fibrinogen, growth hormone (GH) were determined with methods routinely used in clinical laboratories. A quantitative real-time PCR (qRT-PCR) Balnea 2012, núm. 6, 192-193 192 ISBN: 978-84-669-1887-0 978-84-669-3482-4
Balnea 2012, núm. 6, 192-193 Medical Hydrology and Balneology: Environmental Aspects protocol was developed to determine HSP-70 levels. Total RNA was isolated and retrotranscribed into cDNA. Relative quantification was performed using an housekeeping gene as reference. Data were analysed using SPSS 16.0.2 software. Results The analysis of gene expression data shows a direct correlation between HSP-70 levels and thermal treatment. These results indicate that the variation in HSP70 expression may be dependent at least partially by the thermal treatment. Furthermore, there is a functional relationship between the changes in HSP-70 levels and the biochemical parameters analyzed in this study. Conclusions The results provide initial insights to support the relationships between hormetic pathways and thermal treatments. Keywords: Hormesis, Hsp-70, Thermal Treatment 193
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Balnea ISSN: 978-84-669-3482-4 Núm
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Balnea 2012, Núm. 6, 9-24 Contents
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Posters Papers Balnea 2012, Núm. 6
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38 th World Congress of the Interna
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38 th World Congress of the Interna
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Honorary Committee Honorary Preside
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PROGRAMME
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34 Medical Hydrology and Balneology
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SCIENTIFIC SESSIONS
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What’s new in Balneology? Karagü
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Balneology in Europe: results of a
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Balneology Research in Germany Gute
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Balneology Research in France Roque
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The State of art - Session 01 Lectu
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Medical Hydrology and Balneology: E
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Health resort therapy (spa therapy)
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The State of art, Health Resort Med
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State of the art, Health Resort Med
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The State of the art, Health Resort
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Impact of sulphurous water endotymp
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Balnea 2012, núm. 6, 64-65 Medical
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Methodology of Scientific Investiga
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Effectiveness the treatments with n
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Building a preventive medicine mode
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Climatotherapy - Thalassotherapy -
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Is Thalassotherapy simply a type of
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Assessment of the impact of weather
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Marine zootherapy as part of thalas
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Thalassotherapy and otaridotheraphy
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Thalasso medical centre in the salt
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Acute atopic dermatitis and balneot
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Change of the psoriasis area and se
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Climatotherapy - Dead Sea - Session
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Ultra-violet (UV) radiation propert
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Climatotherapy of skin diseases at
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Influence of single immersion in De
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New Trends 2 - Session 06 Lectures
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Implementing comprehensive care cli
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Results 138 Medical Hydrology and B
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Page 134 and 135: Medical Hydrology and Balneology: E
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Threats and opportunities facing Fr
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Balnea 2012, núm. 6, 244-245 Medic
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Miscellaneous - 1 - Session 14 Lect
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“Balneo-check”: software for ba
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Clinical practice and scientific in
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Sociedad Española de Hidrología M
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The story of Spanish Society Medica
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Medical Hydrology and Climatology T
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Hippolytus´ house: a roman medical
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Spatio-cultural sustainability of t
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An introduction to clinical ethics
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Influence of sodium alginate on the
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Bathing in hot water, utilizing ons
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POSTERS PAPERS
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Omega-6-eicosanoid may be involved
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Health effects attributed to endocr
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Underground microclimate influence
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Carbogaseous mineral water for pati
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A developing complex research on na
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An analysis of the behaviour of a m
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Technical audit of the thermal wate
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New trends P9 Does balneology still
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Balnea 2012, núm. 6, 325-327 Medic
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Effectiveness of exercise program f
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Sulphurous mineral water for lower
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Salt mines therapy for pulmonary re
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High concentration artificial CO2-w
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Hypoxic adaptation in patients with
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Control of legionella Benhammou S (
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Puente Viesgo’s spa therapy for p
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Association of behaviral and psycho
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Effects of a rehabilitation treatme
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Water physical therapy is effective
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Effects on body composition in brea
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Depression and thermal treatments:
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Analysis of the effects of a hydrot
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A comparison land-water environment
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Aquatic physiotherapy program in pr
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Physiotherapy and low back pain: ef
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Musculoskeletal disorders and aquat
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Nutrition as a potential determinan
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Magnesium waters from Serbia Jovano
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Neurological activity of mineral wa
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Diuresis-crenotherapy in reno-urina
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Mud therapy resources in Bulgaria I
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Mud maturation in Copahue, Argentin
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Efficacy and tolerability of mud pa
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Climatotherapy - Thalassotherapy De
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Temperature and relative air humidi
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The medical spa preferences of the
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Therapeutic indications of the mine
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Study of density, thermal conductiv
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Efficency of underwater ultrasound
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Health workers knowledge about medi
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Historiography of acidulous waters
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Perception and Knowledge about Baln
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Splendour and decadence of spa tour
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Aqui o Thermes, cluster thermal aqu
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Traffic evolution of the website of
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Abramovic D: 181 Adeagbo JT: 272 Ad
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Fernández-González MV: 387, 389,
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Metlak A: 227 Michán A: 102 Mígue
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Vita P: 74 Vitale M: 46, 63 Vitoria
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