Medical Hydrology and Balneology: Environmental Aspects

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Sulfurous-arsenical-ferruginous thermal water nasal irrigation and wound healing after endoscopic surgery for chronic rhinosinusitis: a prospective, randomized study Staffieri A (1) , Ottaviano G (1) , Staffieri C (1) , Lionello M (1) , Marioni G (1) (1) Department Neurosciences. Section of Otolaryngology. University of Padova. Italy alberto.staffieri@unipd.it Introduction and Objectives Although several publications reported the benefits of nasal irrigation in the management of chronic rhinosinusitis and in sinonasal postoperative care, the available investigations are often small and poorly controlled, and unsupported conclusions are sometimes drawn. The aim of this prospective randomized study was to compare the effects of sulfurous-arsenical-ferruginous thermal water from Levico Spa (Levico Terme, Trento, Italy) nasal irrigation vs isotonic sodium chloride solution nasal irrigation after functional endoscopic sinus surgery (FESS) for chronic sinonasal disease. The histological characteristics of wound healing and the roles played by inflammatory cells in mucosal repair after sinus surgery were investigated. Materials and Methods Eighty patients who consecutively underwent FESS were randomly assigned (1:1) to postoperative nasal irrigation with sulfurous-arsenical-ferruginous thermal water or isotonic sodium chloride solution for 6 months. Intraoperative and postoperative (1, 3, and 6 months) mean counts of lymphocytes, neutrophils, eosinophils, plasma cells, histiocytes, and mast cells in ethmoid biopsies were blindly determined by a pathologist. Results A statistically significant reduction of eosinophil count was disclosed 6 months postoperatively only after sulfurous-arsenical-ferruginous solution nasal irrigation (P = .04). After isotonic sodium chloride solution nasal irrigation, the mean eosinophil count in 6-month postoperative biopsies did not decrease. After both irrigation modalities, the mean mast cell counts in 6-month postoperative biopsies were significantly lower than in intraoperative biopsies (P < .05). Neutrophils, lymphocytes, histiocytes, and plasma cell counts were not significantly different between intraoperative vs 6-month postoperative biopsies independently from irrigation modality. Balnea 2012, núm. 6, 70-71 70 ISBN: 978-84-669-1887-0 978-84-669-3482-4
Balnea 2012, núm. 6, 70-71 Medical Hydrology and Balneology: Environmental Aspects Conclusions Locally reducing the eosinophil number, sulfurous-arsenical-ferruginous solution nasal irrigation may limit eosinophil-mediated production of cytokines and inflammatory molecules, which damage nasal mucosa, leading to edema and sinonasal inflammation. Considering that eosinophils play a particularly important role in allergic response through the release of mediators as eosinophilic cationic protein, major basic protein, and leukotriene C4, which cause extracellular matrix deposition, epithelial denudation, and basement membrane. disruption, sulfurousarsenical-ferruginous solution nasal irrigation significantly reducing the local eosinophil count should be suggested in particular for allergic patients after FESS for chronic rhinosinusitis. Keywords: Chronic Rhinosinusitis, Functional Endoscopic Sinus Surgery, Nasal Irrigation, Sulfurous-Arsenical-Ferruginous Thermal Water, Wound Healing 71
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Balnea ISSN: 978-84-669-3482-4 Núm
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Balnea 2012, Núm. 6, 9-24 Contents
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Page 11 and 12: Posters Papers Balnea 2012, Núm. 6
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Page 17 and 18: 38 th World Congress of the Interna
Page 19 and 20: 38 th World Congress of the Interna
Page 21 and 22: Honorary Committee Honorary Preside
Page 23: PROGRAMME
Page 26 and 27: 34 Medical Hydrology and Balneology
Page 29: SCIENTIFIC SESSIONS
Page 33 and 34: What’s new in Balneology? Karagü
Page 35 and 36: Balneology in Europe: results of a
Page 37 and 38: Balneology Research in Germany Gute
Page 39 and 40: Balneology Research in France Roque
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Page 46 and 47: Health resort therapy (spa therapy)
Page 48 and 49: The State of art, Health Resort Med
Page 50 and 51: State of the art, Health Resort Med
Page 52 and 53: The State of the art, Health Resort
Page 55 and 56: Impact of sulphurous water endotymp
Page 57 and 58: Balnea 2012, núm. 6, 64-65 Medical
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Page 84 and 85: Effectiveness the treatments with n
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Page 94 and 95: Is Thalassotherapy simply a type of
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Ultra-violet (UV) radiation propert
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Climatotherapy of skin diseases at
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Medical Hydrology and Balneology: E
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Influence of single immersion in De
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New Trends 2 - Session 06 Lectures
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Implementing comprehensive care cli
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Results 138 Medical Hydrology and B
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Thermophysical study of peat from t
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Société Française de Médecine T
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Therapeutic education programs for
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Metabolic Syndrome: education progr
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Development of a therapeutic progra
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Therapeutic education for patients
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Withdrawal from benzodiapezines in
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A proposal for a glossary of peloid
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Biophysical skin effects of peloids
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Mud cure in Russia: history, achiev
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Clinical effects of mud-bath therap
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Impact of peloidotherapy on hystolo
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Impact of Mud Therapy in pathogenes
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Effects of mud-bath applications on
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Chondrogenic effect of the sulphuri
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Balneotherapy and mud-therapy in kn
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Biology - Session 09 Lectures Vetri
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Which is better for health promotio
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Heat-shock protein 70 is affected b
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A possible physiological mechanism
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Thermal changes of fingers after co
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Case study: geochemical transformat
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Hydrogen sulfide as an anti-inflama
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Determination of selenium in minera
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Scientific Basics of Water and Hydr
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Balnea 2012, núm. 6, 208-209 Medic
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Health tourism sustainable - Enviro
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Recent contributions of the Geologi
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Salt rooms and halotherapy in europ
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Meteo-climatic factors influence an
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Carbocrenotherapy and the scleroder
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Legionella infection from spa water
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Threats and opportunities facing Fr
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Miscellaneous - 1 - Session 14 Lect
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“Balneo-check”: software for ba
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Clinical practice and scientific in
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Sociedad Española de Hidrología M
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The story of Spanish Society Medica
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Medical Hydrology and Climatology T
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Hippolytus´ house: a roman medical
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Spatio-cultural sustainability of t
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An introduction to clinical ethics
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Influence of sodium alginate on the
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Bathing in hot water, utilizing ons
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POSTERS PAPERS
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Omega-6-eicosanoid may be involved
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Health effects attributed to endocr
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Underground microclimate influence
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Carbogaseous mineral water for pati
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A developing complex research on na
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An analysis of the behaviour of a m
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Technical audit of the thermal wate
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New trends P9 Does balneology still
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Effectiveness of exercise program f
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Sulphurous mineral water for lower
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Salt mines therapy for pulmonary re
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High concentration artificial CO2-w
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Hypoxic adaptation in patients with
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Control of legionella Benhammou S (
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Association of behaviral and psycho
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Effects of a rehabilitation treatme
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Water physical therapy is effective
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Effects on body composition in brea
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Depression and thermal treatments:
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Analysis of the effects of a hydrot
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Aquatic physiotherapy program in pr
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Physiotherapy and low back pain: ef
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Musculoskeletal disorders and aquat
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Nutrition as a potential determinan
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Magnesium waters from Serbia Jovano
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Neurological activity of mineral wa
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Diuresis-crenotherapy in reno-urina
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Mud therapy resources in Bulgaria I
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Mud maturation in Copahue, Argentin
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Efficacy and tolerability of mud pa
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Climatotherapy - Thalassotherapy De
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Temperature and relative air humidi
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The medical spa preferences of the
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Therapeutic indications of the mine
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Study of density, thermal conductiv
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Health workers knowledge about medi
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Historiography of acidulous waters
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Perception and Knowledge about Baln
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Splendour and decadence of spa tour
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Aqui o Thermes, cluster thermal aqu
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Traffic evolution of the website of
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Abramovic D: 181 Adeagbo JT: 272 Ad
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Fernández-González MV: 387, 389,
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Metlak A: 227 Michán A: 102 Mígue
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Vita P: 74 Vitale M: 46, 63 Vitoria
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