revised final - Agency for Toxic Substances and Disease Registry ...

MERCURY A-9
APPENDIX A
If so, explain: Yes. The dose was adjusted for a continuous exposure by multiplying the NOAEL (0.23
mg/kg/day) by a conversion factor of 5/7:
NOAEL (ADJ)
= 0.23 mg/kg/day x (5 days/7 days)
= 0.16 mg/kg/day
MRL = NOAEL (ADJ) ÷ UF = 0.16 mg/kg/day ÷ 100 = 0.002 mg/kg/day
If an inhalation study in animals, list conversion factors used in determining human equivalent dose:
Not applicable.
Additional studies or pertinent information that lend support to this MRL: Renal toxicity has been observed
in other intermediate-duration oral studies on rats and mice exposed to inorganic mercury (Carmignani et al.
1992; Jonker et al. 1993a; NTP 1993), as well as case reports on humans ingesting inorganic mercury for
acute and chronic durations (Afonso and deAlvarez 1960; Davis et al. 1974; Kang-Yum and Oransky 1992;
Nielsen et al. 1991; Pesce et al. 1977).
Agency Contact (Chemical Manager): John Risher