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Portada Simposios - Supplements - Haematologica

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XLII Reunión Nacional de la AEHH y XVI Congreso de la SETH. <strong>Simposios</strong><br />

133<br />

using AAV to deliver FIX in haemophiliacs are encouraging,<br />

allowing us to face the future with optimism.<br />

References<br />

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adenoviral vector encoding canine factor VIII: high-level, sustained expression<br />

in hemophiliac mice. Hum Gene Ther 1999; 10: 1791-1802.<br />

3. Wang L, Takabe K, Bidlingmaier S et al. Sustained correction of bleeding<br />

disorder in hemophilia B mice by gene therapy. Proc Natl Acad<br />

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B: Sustained partial correction in factor IX deficient dogs.<br />

Science 1993; 262: 117-119.<br />

5. Chuah MK, Collen D, Vandendriessche T. Gene therapy for hemophilia:<br />

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8. Marshall E. Gene therapy death prompts review of adenovirus vector.<br />

Science 1999; 286: 2244-2245.<br />

9. Snyder RO, Miao CH, Patijn GA et al. Persistent and therapeutic concentrations<br />

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11. Snyder RO, Miao C, Meuse L et al. Correction of hemophilia B in canine<br />

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Nat Med 1999; 5: 64-70.<br />

12. Herzog RW, Yang EY, Couto LB et al. Long-term correction of canine<br />

hemophilia B by gene transfer of blood coagulation factor IX mediated<br />

by adeno-associated viral vector. Nat Med 1999; 5: 56-63.<br />

13. Kay MA, Manno CS, Ragni MV et al. Evidence for gene transfer and expression<br />

of factor IX in haemophilia B patients treated with an AAV vector.<br />

Nat Genet 2000; 24: 257-261.<br />

14. Chao H, Mao L, Bruce AT, Walsh CE. Sustained expression of human<br />

factor VIII in mice using a parvovirus-based vector. Blood 2000; 95:<br />

1594-1599.<br />

15. Burton M, Nakai H, Colosi P et al. Coexpression of factor VIII heavy<br />

and light chain adeno-associated viral vectors produces biologically active<br />

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