Appendix D Food Codes for NHANES - OEHHA

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Scientific Review PanelSRP Draft Version 2 February,June 2012 Chemical/ group TEF 1984/5 (diet) a J-10 1994 (diet) a 1988 (milk) b 1993 (milk) a 1978 (diet) a Mean, SD Mean, SD Mean, SD Mean, SD Mean, SD pg/d* pg/d* pg/d* pg/kg- pg/kg milk -milk PeCDF 2,3,4,7,8- 0.5 720, PeCDF 178.8, 25.03 65.4, 13.73 23.4, 12.87 807,108 300 1,2,3,4,7,8- 0.1 208, HxCDF 178.8, 30.40 43.8, 9.20 27.6, 11.04 293,20 92 1,2,3,6,7,8- 0.1 176, HxCDF 54, 3.78 27, 6.21 13.8, 5.52 261,17 84 1,2,3,7,8,9- 0.1 HxCDF
Scientific Review PanelSRP Draft Version 2 February,June 2012 estimates in units of mass/body weight/day. Therefore, we converted their estimates to units of mass/day by multiplying by the default 60 kg body weight used by Liem et al (Liem et al., 2000). Liem et al. (2000) reported dietary intake for three time-periods (see Table J.2- 1)(Liem et al., 2000). Dietary intake estimates were based on concentrations of PCDD/Fs and PCBs measured in composite samples of 24-hr duplicate diets in the Dutch adult population in 1978, 1984-85, and 1994 and combined with individual consumption data collected in 1987-1988 (Albers et al., 1996) (briefly summarized previously) for approximately 6000 individuals from 2200 families over a 2-day period . In a separate study, these same investigators estimated dioxin and dioxin-like compounds in human milk fat collected in the period 1992- 1993 from more than 80 women (Liem et al., 1995; Liem et al., 2000). Liem et al. (2000) observed a downward trend in estimated dietary intake of individual congeners of PCDDs PCDFs and PCBs in the Dutch population during three intervals from 1978 to 1994 (see Table J.2-1)(Liem et al., 2000). A downward trend was also seen in a study of these toxicant levels in the diet and human milk of the German population from 1983 - 2003 (Furst, 2006; Wilhelm et al., 2007). However, about half of the mono-ortho PCBs did not show a similar linear decline. This pattern is consistent with observations made by Alcock et al., (1996) who reported some evidence that the environmental load of PCDD/Fs increased in the 1960s, peaked around 1975 and then began to decline (Alcock et al., 1996). OEHHA has derived lactational transfer coefficients for PCDD/Fs and dioxin-like PCBs from studies of exposure from global sources and by multiple pathways. The proportional contribution from various exposure pathways to total exposure from a single Hot Spots facility is likely to be quite different from that found from global sources. However, we assume that the estimate of transfer to milk from global sources, such as that derived from the Dutch studies, reasonably represents the transfer in persons from communities near Hot Spot facilities in California. The Hot Spots program allows for reporting emissions of individual congeners of dioxins, furans and PCBs, when emissions are speciated. It also permits reporting of emissions as total dioxins and furans or PCBs. Speciation of emissions produces a more accurate (and lower) risk estimate. This is because unspeciated emissions are assumed to be 2,3,7,8-TCDD, which has the highest potency factor among the dioxins and furans. Therefore, OEHHA has derived congener Tcos for individual PCBs and dioxins that can be used when emissions are speciated. J.2.3 Mothers’ Milk Transfer Coefficients (Tco) for PCDD/Fs and PCBs J-11
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Appendix D Food Codes for NHANES - OEHHA

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