Appendix D Food Codes for NHANES - OEHHA

Scientific Review PanelSRP Draft Version 2 February,June 2012
Tco = (t1/2)(f1)(f3)/(BW)(f2)(0.693) Eq J-6
Note that Emi in equation J-4 = (Cf)(I)/BW with units of mg/kg-BW/day. BW is the
average adult body weight of the mother (kg).
Transfer coefficients (Tcos) in Table J.2-3 (column-2) combine milk data (milk
concentration of PCDD/Fs and PCBs) with dietary intake estimates listed in
Table J.2-1. OEHHA derived individual Tcos from data presented in (Liem et al.,
1995; Albers et al., 1996; Liem et al., 2000). Because the median is a reasonable
estimate of the geometric mean in skewed distributions, Tcos were derived from
median half-lives listed in column-5 of Table J.2-2. Tcos range from less than
one to more than ten d/kg-milk among dioxins and furan and less than two to
more than 20 d/kg-milk among dioxin-like compounds.
Table J.2-3: Arithmetic Mean Transfer Coefficients (Tcos) for Individual
PCDD/F and PCB Congeners Measured in Human Milk and Dietary Intake
from a Dutch Population (d/kg-milk) Compared to the Median and
Geometric Mean Tcos Derived from Reference Half-lives (t1/2) and Equation
J-6
Chemical/group
Tcos
(GM)
based
on slope
factors
Tco based
on median
reference
half life
(Milbrath et
al 2007)
J-16
Tco
based
on
t1/2
GM*
Tco
based
on
t1/2
GSD
Tco
based
on
t1/2
LCL
Tco
based
on
t1/2
UCL
2,3,7,8-TCDD 49.62 5.36 4.02 2.76 2.14 7.53
1,2,3,7,8-PeCDD 8.76 7.24 6.53 2.16 3.07 13.90
1,2,3,4,7,8-HxCDD 0.98 9.28 5.60 3.41 1.40 22.48
1,2,3,6,7,8-HxCDD 11.02 10.21 3.27 4.20 0.80 13.32
1,2,3,7,8,9-HxCDD
4.89 5.79 3.32 1.91 1.60 6.88
1,2,3,4,6,7,8-HpCDD 2.88 3.15 1.96 2.74 0.73 5.26
OctaCDD 5.54 4.85 2.29 3.25 0.72 7.28
2,3,7,8-TCDF 3.18 0.77 1.76 1.36 0.96 3.23
1,2,3,7,8-PeCDF 3.43 1.62 1.91 2.49 0.78 4.68
2,3,4,7,8- PeCDF 2.77 4.17 1.78 4.24 0.88 3.62
1,2,3,4,7,8-HxCDF 2.16 4.09 0.99 5.29 0.41 2.38
1,2,3,6,7,8-HxCDF 7.89 5.11 2.64 3.01 1.09 6.39
1,2,3,7,8,9-HxCDF NA NA NA NA NA NA
2,3,4,6,7,8-HxCDF 3.18 2.89 0.55 3.18 0.22 1.39
1,2,3,4,6,7,8-HpCDF 2.40 2.55 1.82 1.63 1.36 2.44
1,2,3,4,7,8,9-HpCDF NA 4.43 3.63 1.34 2.06 6.42
OctaCDF 0.32 1.36 0.99 2.83 0.13 7.55
PCB-77 NA NA 0.06 6.38 0.004 0.72
PCB-81 NA NA 0.38 1.35 0.248 0.57