Handbook of Vitamin C Research

Vitamin C in the Treatment of Endothelial Dysfunction 351[16] Vlachopoulos, C; Tsekoura, D; Alexopoulos, N; Panagiotakos, D; Aznaouridis, K;Stefanadis, C. Type 5 phosphodiesterase inhibition by sildenafil abrogates acutesmoking-induced endothelial dysfunction. Am J Hypertens, 2004. 17: 1040-1044.[17] Mangoni, AA; Sherwood, RA; Asonganyi, B; Swift, CG; Thomas, S; Jackson, SH.Short-term oral folic acid supplementation enhances endothelial function in patientswith type 2 diabetes. Am J Hypertens, 2005. 18: 220-226.[18] Stirban, A; Negrean, M; Stratmann, B; Gawlowski, T; Horstmann, T; Gotting, C;Kleesiek, K; Mueller-Roesel, M; Koschinsky, T; Uribarri, J; Vlassara, H; Tschoepe, D.Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidativestress following a meal rich in advanced glycation end products in individuals withtype 2 diabetes. Diabetes Care, 2006. 29: 2064-2071.[19] Hadi, HA; Carr, CS; Al, SJ. Endothelial dysfunction: cardiovascular risk factors,therapy, and outcome. Vasc Health Risk Manag, 2005. 1: 183-198.[20] Heitzer, T; Krohn, K; Albers, S; Meinertz, T. Tetrahydrobiopterin improvesendothelium-dependent vasodilation by increasing nitric oxide activity in patients withType II diabetes mellitus. Diabetologia, 2000. 43: 1435-1438.[21] Wever, RM; Luscher, TF; Cosentino, F; Rabelink, TJ. Atherosclerosis and the twofaces of endothelial nitric oxide synthase. Circulation, 1998. 97: 108-112.[22] Halcox, JP; Nour, KR; Zalos, G; Mincemoyer, RA; Waclawiw, M; Rivera, CE; Willie,G; Ellahham, S; Quyyumi, AA. The effect of sildenafil on human vascular function,platelet activation, and myocardial ischemia 1. J Am Coll Cardiol, 2002. 40: 1232-1240.[23] Stirban, A; Laude, D; Elghozi, JL; Sander, D; Agelink, MW; Hilz, MJ; Ziegler, D.Acute effects of sildenafil on flow mediated dilatation and cardiovascular autonomicnerve function in type 2 diabetic patients. Diabetes Metab Res Rev, 2008.[24] Lehr, HA; Germann, G; McGregor, GP; Migeod, F; Roesen, P; Tanaka, H; Uhlig, C;Biesalski, HK. Consensus meeting on "Relevance of parenteral vitamin C in acuteendothelial dependent pathophysiological conditions (EDPC)". Eur J Med Res, 2006.11: 516-526.[25] Darley-Usmar, VM; Hogg, N; O'Leary, VJ; Wilson, MT; Moncada, S. Thesimultaneous generation of superoxide and nitric oxide can initiate lipid peroxidation inhuman low density lipoprotein. Free Radic Res Commun, 1992. 17: 9-20.[26] Myers, PR; Wright, TF; Tanner, MA; Ostlund, RE, Jr. The effects of native LDL andoxidized LDL on EDRF bioactivity and nitric oxide production in vascularendothelium. J Lab Clin Med, 1994. 124: 672-683.[27] Stirban A; Negrean M; Götting C; Uribarri J; Gawlowski T; Stratmann B; Kleesiek K;Koschinsky T; Vlassara H; Tschoepe D. Dietary advanced glycation end products andoxidative stress: in vivo effects on endothelial function and adipokines. Ann N Y AcadSci, 2008. 276-279.[28] Tousoulis, D; Xenakis, C; Tentolouris, C; Davies, G; Antoniades, C; Crake, T;Stefanadis, C. Effects of vitamin C on intracoronary L-arginine dependent coronaryvasodilatation in patients with stable angina. Heart, 2005. 91: 1319-1323.[29] Vergnani, L; Hatrik, S; Ricci, F; Passaro, A; Manzoli, N; Zuliani, G; Brovkovych, V;Fellin, R; Malinski, T. Effect of native and oxidized low-density lipoprotein on