Handbook of Vitamin C Research

60Yasuo Kagawa, Shizu Higasa, Masaru Tsujimura et al.Blood VC concentrations were then compared between the two groups before and at 1and 3 h after loading. Blood VC concentrations and the increase in VC at 1 h after loadingwere significantly higher (p < 0.05 and p < 0.01, respectively) in the DAsA group than in theAsA group. In addition, there was a marginal association (p < 0.066) between SOD2polymorphism (GG, AG and AA) and serum VC concentrations (0.772, 1.202 and 1.24mg/dL, respectively) in a group of young women (n = 148) consuming normal diet.The average values related to oxygen stress during the intervals of the cross-over loadingexperiment, blood analyses of sample subjects (n = 7) were as follows: glutathione, 4.3 ± 4.1mg/dL; vitamin E, 1.13 ± 0.22 mg/dL; malon dialdehyde, 98.1 ± 30.7 U/L; uric acid 4.5 ± 0.8mg/dL; and superoxide dismutases, 0.9 ± 0.2 U/mL. These values were not significantly (p