Handbook of Vitamin C Research

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374Neena Philips[31] Liotta LA; Tryggvason K ; Garbisa S ; Hart I ; Foltz CM ; Shafie S. Metastaticpotential correlates with enzymatic degradation of basement membrane collagen.Nature (1980) 284: 67 -68.[32] Wang XJ. Role of TGF- signaling in skin carcinogenesis. Micro. Res. Tech. (2001)52: 420-429.[33] Wrana JL; Attsiano L; Wiesser R; Ventura F; Massague J. Mechanism of activation ofthe TGF-beta receptor. Nature (1994) 370: 341-347.[34] Derynck R. TGF-beta-receptor-mediated signaling. Trends Biochem. Sci. (1994) 19:548-553.[35] Kawabata M; Miyazono K. Signal transduction of the TGF-beta superfamily by Smadproteins. J. Biochem. (1999) 125: 9-16.[36] Philips N; Keller T; Holmes C. Reciprocal Effects of Ascorbate on Cancer Cell Growthand the Expression of Matrix Metalloproteinases and Transforming Growth Factorbeta.Cancer Letters (2007) 256: 49-55.[37] Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern. Med. Rev.(1998) 3: 174-186.[38] Philips N; Devaney J. Beneficial regulation of type I collagen andmatrixmetalloproteinase –1 expression by estrogen, progesterone, and its combinationin skin fibroblasts. J. Am. Aging Assoc. (2003) 26: 59-62.[39] Frazier K; Williams S; Kothapalli D; Klapper H; Grotendorst GR. Stimulation offibroblast cell growth, matrix production, granulation tissue formation by connectivetissue growth factor. J. Invest. Dermatol. (1996) 107: 404-411.[40] Lin SY; Lai WW; Chou CC; Kuo HM; Li TM; Chung GJ; Yang JH. Sodium ascorbateinhibits growth via the induction of cell cycle arrest and apoptosis in human malignantmelanoma A375.S2 cells. Melanoma Res. (2006) 16: 509-519.[41] Verrax J; Cadrobbi J; Marques C; Taper H; Habraken Y; Piette J; Calderon P B.Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress thatkills cancer cells by a non-apoptotic caspase-3 independent form of cell death.Apoptosis (2004): 223-233.[42] Zhang H. P53 Plays a central role in UVA and UVB induced cell damage andapoptosis in Melanoma cells. Cancer Letters (2005) 244: 229-238.[43] Garrido C; Schmitt E; Cande C; Vahsen N; Parcellier A; Kroemer G. HSP27 and 70:Potential oncogenic apoptotic inhibitors. Cell Cycle (2003) 2: 579-584.[44] Neckers L. Heat shock protein 90: the cancer chaperone. J. Biosci. (2007) 32: 517–530.[45] Trautinger F; Kindas- Mügge I; Dekrout B; Knobler RM; Metze D. Expression of the27-kDa heat shock protein in human epidermis and in epidermal neoplasms: animmunohistological study. Br. J. Dermatol. (1995) 133: 194–202.[46] Overall CM; Kleifeld O. Validating matrix metalloproteinases as drug targets and antitargetsfor cancer therapy. Nature Rev. Cancer (2006) 6: 227-239.[47] Yuan J; Charyl MD; Scully SP. RNAi mediated MMP-1 silencing inhibits humanchondrosarcome invasion. Journal of Orthopaedic Research (2005) 23: 1467-1474.[48] Xiaoling J; Dutton CM; Wen-Ning Q; Block JA; Garamszegi N; Scully SP. siRNAMediated Inhibition of MMP-1 Reduces Invasive Potential of a Human ChondrosomaCell Line. Journal of Cellular Physiology (2005) 202: 723-730.
Reciprocal Effects of Ascorbate on Cancer Cell Growth… 375[49] Sateesh K; Lakka SS; Gondi CS; Estes N; Rao JS. RNAi-mediated downregulation ofurokinase plasminogen activator receptor and matrix metalloproteinase-9 in humanbreast cancer cells results in decreased tumor invasion, angiogenesis and growth.International Journal of Cancer (2007) 121: 2307-2316.[50] El Mourabit H; Fahem A; Hornebeck W; Bernard P; Bellon G. Silencing of Membrane-Type 1 Metalloprotease (MT1-MMP) by Specific siRNAs Supresses the AngiogenicPhenotype of Dermal Endothelial Cells and Inhibits Type 1 Collagen Invasion byMelanoma Cells. J. Invest. Dermatol. (2004) 123: 1523-1747.[51] Philips N; Smith J; Keller T; Gonzalez S. Predominant effects of Polypodiumleucotomos on membrane integrity, lipid peroxidation, and expression of elastin andmatrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, andkeratinocytes. J. Dermatol. Sci. (2003) 32: 1-9.[52] Gonzalez S; Alcaraz MV; Cuevas J; Perez M; Jaen P; Alvarex M.; Villarrubia V. Anextract of the fern polypodium leucotomos (Difur ® ) modulates Th1/Th2 cytokinesbalance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenicrelationships and therapeutic implications. Anticancer Research (2000) 20: 1567-1576.[53] Bernd A; Ramirez-Bosca A; Huber H; Diaz-Alperi H; Thaci D; Sewell A; Auintanilla-Almagro E; Holzmann H. In vitro studies on the immunomodulating effects ofpolypodium leucotomos extract on human leukocyte fractions. Arzneim-Forsch DrugRes. (1995) 45: 901-904.
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ContentsPrefaceChapter IChapter IIC
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PrefaceThe 6-carbon lactone known a
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Prefaceixbalance of antioxidant and
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Prefacexiprovided or is contradicto
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PrefacexiiiChapter IX - Background:
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Prefacexvdetoxification defence sys
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Prefacexviiprogressed faster than i
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In: Handbook of Vitamin C Research
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Human Specific Vitamin C Metabolism
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mgmgmgHuman Specific Vitamin C Meta
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88Ana I. Haza, Almudena García and
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90Figure 1.Ana I. Haza, Almudena Ga
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94Figure 3.Ana I. Haza, Almudena Ga
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100Ana I. Haza, Almudena García an
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In: Handbook of Vitamin C Research:
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Vitamin C: Dietary Requirements, Di
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Oxidative DamageVitamin C: Dietary
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Pro-Oxidant vs. Antioxidant Effects
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Patient. B.H. (38), atopic eczema.V
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186Magdalena Stevanović and Dragan
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Molecular Bases of the Cellular Han
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Vitamin C: Daily Requirements, Diet
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262Alan M. Preston, Luis Vázquez Q
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Percent of Study Group Selecting Di
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The Role of Vitamin C in Human Repr
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300Mustafa NazıroğluKeywords: Vit
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302Mustafa NazıroğluNO is synthes
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304Mustafa Nazıroğlu‗recycling
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306Mustafa Nazıroğluagents, such
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308Mustafa NazıroğluFuture Direct
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310Mustafa Nazıroğlu[21] Basu, TK
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312Mustafa Nazıroğlu[59] Cengiz M
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314Samar Al Sayegh Petkovšek and B
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(mgg -1 )320Samar Al Sayegh Petkov
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Page 344 and 345: 324Samar Al Sayegh Petkovšek and B
Page 350 and 351: 330Antonio J. López-Farré, José
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Page 365 and 366: Vitamin C in the Treatment of Endot
Page 377 and 378: Vitamin C Intake by Japanese Patien
Page 389 and 390: Reciprocal Effects of Ascorbate on
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Page 398 and 399: 378Akihito Ishigamicontrols (12,13)
Page 400 and 401: 380Akihito IshigamiFigure 3. Vitami
Page 402 and 403: 382Akihito IshigamiFuture of the SM
Page 407 and 408: The Importance of Food Processing o
Page 409 and 410: IndexAA , 249abdominal cramps, 243a
Page 411 and 412: Index 391atherosclerotic plaque, 23
Page 413 and 414: Index 393catalase, 6, 13, 169, 181,
Page 415 and 416: Index 395cyclooxygenase-2, 337, 341
Page 417 and 418: Index 397endometrium, 286, 294endon
Page 419 and 420: Index 399GCS, 18gel, x, 87, 92, 121
Page 421 and 422: Index 401hyperglycaemia, 223hypergl
Page 423 and 424: Index 403kinetics, 71, 120, 124, 14
Page 425 and 426: Index 405metastases, 182metastasis,
Page 427 and 428: Index 407nitrate, 14, 88, 179, 234,
Page 429 and 430: Index 409phosphodiesterase, 344, 35
Page 431 and 432: Index 411recovery, vii, 1, 5, 7, 8,
Page 433 and 434: Index 413steady state, 63, 76, 78st
Page 435: Index 415UV, 156, 191, 201, 204, 22
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Handbook of Vitamin C Research

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