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Food Lipids: Chemistry, Nutrition, and Biotechnology

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Scheme 4 Synthesis of squalene from the coupling of two molecules of farnesyl<br />

pyrophosphate.<br />

according to the isoprene rule. The biosynthesis pathway from acetyl CoA to 2,3oxisqualene<br />

in plants is the same as that in animals (see detailed discussion of the<br />

biosynthesis of cholesterol, Sec. II.B.1).<br />

The conversion of cycloartenol to other plant sterols can be generally divided<br />

into three steps, which are the alkylation of the side chain at C-24, demethylation<br />

Scheme 5 Cyclization of squalene.<br />

Copyright 2002 by Marcel Dekker, Inc. All Rights Reserved.

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