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17. Shimizu H, Shargill NS, Bray GA, Yen TT, Gesellchen PD. Effects of MSH on food intake, body weight and coat color of the yellow obese mouse. Life Sci 1989;45:543–52. 18. Abbott CR, Rossi M, Kim M-S, AlAhmed SH, Taylor GM, Ghatei MA, Smith DM, Bloom SR. Investigation of the melanocyte stimulating hormones on food intake. Lack of evidence to support a role for the melanocortin-3-receptor. Brain Res 2000;869:203–210. 19. Guo L, Mu¨ nzberg H, Stuart RC, Nillni EA, Bjørbæk C. N-acetylation of hypothalamic α- melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci USA 2004; 101:11797-11802. 20. Dhillo WS, Small CJ, Gardiner JV, Bewick GA, Whitworth EJ, Jethwa PH, Seal LJ, Ghatei MA, Hinson JP, Bloom SR. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Biochem Biophys Res Commun 2003;301:102–107. 21. Liakos P, Chambaz EM, Feige JJ, Defaye G. Expression of ACTH receptors (MC2-R and MC5-R) in the glomerulosa and the fasciculata-reticularis zones of bovine adrenal cortex. Endocr Res 1998;24:427–432. 22.Henville KL, Hinson JP, Vinson GP, Laird SM. Actions of desacetyl-α-melanocyte-stimulating hormone on human adrenocortical cells. J Endocrinol 1989;121:579–583. 23. Baumann JB, Eberle AN, Christen E, Ruch W, Girard J. Steroidogenic activity of highly potent melanotropic peptides in the adrenal cortex of the rat. Acta Endocrinol 1986;113:396–402. 24. Rudman D, Hollins BM, Kutner MH, Moffitt SD, Lynn MJ. Three types of α-melanocytestimulating hormone: bioactivities and half-lives. Am J Physiol 1983; 245:47–54. 25. Schio¨th HB, Chhajlani V, Muceniece R, Klusa V, Wikberg JES. Major pharmacological distinction of the ACTH receptor from other melanocortin receptors. Life Sci 1996; 59:797–801. 26. Boston BA. The role of melanocortins in adipocyte function. Ann NY Acad Sci 1999; 885:75–84. 27. Hoggard N, Hunter L, Duncan JS, Rayner DV. Regulation of adipose tissue leptin secretion by α- melanocyte stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system. J Mol Endocrinol 2004;32:145–153. 60
Investigation of the mechanism of the cardioprotective effect of flavonols Chengxue Qin, 1,2 * Richard A. Hughes, 1 Spencer J. Williams, 2 Owen L. Woodman 3 * Presenter 1. The Department of Pharmacology, University of Melbourne, Parkville, 3010 2. School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, 3010 3. School of Medical Sciences, RMIT University, Bundoora, 3083 We have reported that 3’, 4’-dihydroxyflavonol (DiOHF) reduces infarct size after myocardial ischaemia/reperfusion in sheep [1] and ischaemic stroke in rats [2]. It is however not known whether the cardioprotective action of this flavonol relies on its anti-calcium or antioxidant activities. In this study, we investigated the mechanism of the beneficial action of flavonols using our recently discovered single-action anti-calcium compound (4’-OH-3’-OCH 3 flavonol) [3] and the complementary antioxidant compound (DiOHF-6-succinamic acid) [4] in rat isolated hearts. Hearts were perfused with physiological solution using a Langendorff apparatus and subjected to global, no-flow 20-minute ischaemia followed by 30-minute reperfusion. Hearts (n = 6~8 each group) were randomly treated with vehicle (0.05% DMSO), DiOHF, 4’-OH-3’- OCH 3 flavonol or DiOHF-6-succinamic acid. Treatments (10 -5 M) were included in the perfusate for 10 min before ischaemia and during reperfusion. In vehicle treated hearts, LV+dP/dt was significantly reduced at the end of reperfusion (60±8%) compared to the preischaemic value. Furthermore, total lactate dehydrogenase (LDH) release was significantly elevated during reperfusion in vehicle treated hearts (895±121 U/L) compared to shams (70±10 U/L), indicating significant myocardial damage (p
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The 3 rd VACPS Research Workshop Pr
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Organizing Committee Victorian Asso
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Preface On the occasion of the publ
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Paper as a low-cost base material f
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Acknowledgements We gratefully ackn
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Career planning and Job Interview i
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The role of mitochondria in atrial
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Page 59 and 60: Materials and Methods Ethics All an
Page 61 and 62: Fig.1 (A) Mass Spectrometry results
Page 63 and 64: indicated that there is more des-α
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Page 78 and 79: workflows. By comparing the generat
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Page 84 and 85: A Multi-modal Gesture Recognition S
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[37] A. Motayed, M. Q. He, A. V. Da
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Fig. 1. The transverse and longitud
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References: [1] Xiong Liu, Mark C.
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new tissue[10]. Most of these human
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2.8 Viability and morphology study
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Fig 3 and 4 SEM images of electrosp
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studies have indicated that surface
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Fig 10 Tensile Stress curve of elec
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well as on a usual nanofibrous scaf
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Uniform Coating of WO x on TiO 2 Na
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Union as a Social Regulator of Mark
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associated with a reinvention of in
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enterprises…There obviously is no
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Union assistants participate in org
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[5] Deyo, Frederic C and Ağartan,
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Organizational Capabilities • Lea
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Table 1. Correlations, Reliabilitie
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[18]. Jap, S. D. (1999). Pie-expans
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Early Childhood Education Matters:
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decisions on selection of child car
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Noble, K. (2007). Parent choice of
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An Exploration of Country of Origin
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Supercontinuum generation for fiber
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Gas chromatographic retention indic
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Outward Foreign Direct Investment f
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Fiber Nonlinearity Precompensation
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Improved Nonlinearity precompensati
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