Clinical Trials and Preclinical Infrastructure Asset Map - Life Sciences

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6 BRITISH COLUMBIA TABLE 1. Health Authorities and Key Hospitals/ Agencies that Conduct Clinical Trials (cont’d) Health Authority (URL) Key Facilities Location URL Victoria General Hospital Victoria www.viha.ca/finding_care/facilities/victoria_general_hospital.htm Vancouver Coastal Health Authority UBC Hospital Vancouver n/a (VCH) (www.vch.ca) Vancouver General Hospital (VGH) Vancouver n/a Providence Health Care Society (Providence) 4 (www.providencehealthcare.org) St. Paul’s Hospital Vancouver www.providencehealthcare.org/info_ stpauls_main.html Mount Saint Joseph Hospital Vancouver www.providencehealthcare.org/info_msj_ main.html In addition, some clinical studies involve researchers (such as epidemiologists) at Simon Fraser University (SFU), UBC, the University of Victoria (UVic), and the B.C. Institute of Technology (BCIT). Furthermore, although they do not conduct clinical trials themselves, some other PHSA agencies may coordinate trials within their disease specialties: B.C. Mental Health & Addictions Services, B.C. Transplant Society, Cardiac Services B.C., Provincial Renal Agency, and Provincial Specialized Perinatal Services. Clinical Trials Units, Centres, and Study Sites B.C. has at least 59 clinical trials units (CTUs), centres 5 , study sites, and medical departments 6 that encourage clinical trials located in the hospitals and agencies listed in Table 1 7 . These are presented in Figure 1. The classification of the facilities by disease is shown in Figure 2, while a summary of each entity according to disease area can be found in Table 2. Appendix 1 contains details of each clinical trials unit, centre, and study site. Extrapolating from the responses of all 18 facilities that were interviewed in-depth specifically for this report 8 , all 59 units have the capacity and desire to conduct additional trials. A number of the facilities included in the listings are not fully fledged CTUs or Clinical Trials Centres. They generally employ study nurses or coordinators and are supported by one of the Clinical Trials Support Units described below 9 . In addition, some of the Province’s smaller hospitals, such as Cowichan District, Langley Memorial, Chilliwack General, Ridge Meadows, and Vernon Jubilee, have individual investigators who perform clinical trials. These investigators are listed in Appendix 6. 4 Providence is an independent legal entity aligned with VCH for operational purposes. 5 For this report, a Clinical Trials Unit or Clinical Trials Centre has been defined as a cohesive entity with dedicated study nurses and data managers. It acts as an independent management unit even if it has no dedicated space. 6 Medical departments that support clinical trials are, at the very least, study sites, and are often CTUs. 7 Note that the CTUs, centres, and study sites included here are probably not all-inclusive. The listings contain only those facilities that the authors were able to discover through extensive searches and discussions with hospital and health authority personnel. 8 These facilities are marked with a • in Table 2. 9 Although many of the facilities provide leadership in clinical trials, the way the data were collected did not generally allow a distinction between those that provided leadership and those that just provided patients (i.e., were study sites). Thus, for fairness to all the facilities, none have been tagged as leaders. The details presented in Appendix 1 provide some information of the leadership position for some centres.
CLINICAL TRIALS AND PRECLINICAL INFRASTRUCTURE ASSET MAP 7 All CTUs and Clinical Trial Centres offer: • Principal and associate investigators • Expertise in industry sponsored, investigator-initiated, and grant sponsored studies • Study nurses/ coordinators • Data managers/ coordinators • Pharmacy and laboratory staff as needed • Quality control/ assurance procedures, of which Standard Operating Procedures (SOPs) and Good Clinical Practice (GCP) regulations and guidelines provide an integral part • Administrative services including contracts and other legal documents; budget negotiation; accounting; research ethics board (REB) submissions; regulatory documentation and coordination, including safety and other required reports. FIGURE 1. B.C.’s Hospital/Agency Based Clinical Trials Units, Centres, and Study Sites that Support Clinical Trials PHSA Alzheimer’s Clinic Arthritis Research Centre Bladder Care Centre Cardiology/Research Centre for Ovulation & Menstrual Cycle Research Centre for Stroke & Cerebrovascular Diseases Dermatology CTU Diabetes Res. Centre Downtown ID Clinic Epilepsy Clinic Hematology Research & CTU VCHRI Clinical Research Unit VCH The Lung Centre Mood Disorders Centre of Excellence CT Section Multiple Sclerosis Clinic Neurosurgery Division Pacific Parkinson’s Res. Centre The Vancouver Prostate Centre at VGH Psychiatry Administration Division Retinal Research Group Endocriminology & Metabolism Gastroenterology Nephrology Res. Unit/Group UBC Critical Care Medicine PHC AIDS Research Program CIHR Canadian HIV Trials Network Emergency Medicine Res. Group Foot & Ankle Clinic Heart Centre Hematology Res. Group James Hogg iCAPTURE Centre Pacific Lung Health Centre PHCRI Centre for Health Evaluation and Outcome Sciences BCCA Edward Miller Clinical Research Unit Medical Oncology Vancouver Centre CTU Radiation Therapy (RT) Research Program Southern Interior CTU VIC RT Research Business Unit VIC Systemic Therapy CTU BCCH Vaccine Evaluation Centre Endocrinology & Diabetes Unit Neurosciences Program Neonatal Research Team Rheumatology Program Women & Family HIV Centre Pediatric Oncology/ BMT Hematology Provincial Medical Genetics Program Pediatric Anesthesia Dept. General Surgery CFRI Clinical Research Support Unit BCWH BCCDC Labratory Clinical Studies Unit FH Burnaby Hospital Regional Cancer Centre Cardiology Clinical Trials Inc. Multiple Sclerosis Clinic IHA Penticton Regional Hospital Research Dept. VIHA Critical Care Group Orthopedics Dept. Ridge Meadows Hospital Dept. of Evaluation & Research Services Kidney Clinic UBC Obs&Gyn Anesthisiology Res. VIHA Research Dept. Clinical Trials Support Units CTUs/ Centres/ Sites & Depts. that Support Clinical Trials Health Authorities/ Agencies VCH-Vancouver Coastal Health PHC-Providence Health Care Society PHSA- Provincial Health Services Authority BCCA- B.C. Cancer Agency FH- Fraser Health Authority BCCH- B.C. Children’s Hospital BCWH- B.C. Women’s Hospital BCCDC- B.C. Centre for Disease Control IHA- Interior Health Authority VIHA- Vancouver Island Health Authority
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