Clinical Trials and Preclinical Infrastructure Asset Map - Life Sciences

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52 BRITISH COLUMBIA APPENDIX 1. DESCRIPTION OF B.C.’S CLINICAL TRIALS UNITS, CENTRES, AND STUDY SITES PROVINCIAL HEALTH SERVICES AUTHORITY B.C. Cancer Agency The British Columbia Cancer Agency (BCCA) (www.bccancer.bc.ca) is responsible for both patient care and research within a single operational structure. It provides a population-based cancer care program, including prevention, screening and early detection, diagnosis and treatment services, rehabilitation support and community programs, research, and education. Thus, unlike most other jurisdictions which move patients from primary and secondary to tertiary care facilities as their disease progresses, B.C.’s cancer patients are generally managed by the same tumour specific team from first therapy to final outcome. A complete record of a patient’s management (e.g., therapy, outcomes, etc.) is housed within a centralized registry managed by the BCCA. Biological samples from each patient are stored in biorepositiories. Tumour teams are responsible for therapeutic protocols and policy decisions, rapidly translating experimental medicines and novel processes into routine care if the outcomes data support this. FIGURE A1. Key Clinical Trials and Preclinical Studies Facilities at the BCCA BCCA Clinical Trials Unit Advanced Therapeutics Investigational Drug Program Tumour Tissue Repository Medical Oncology, Vancouver Centre Edward Miller, Fraser Valley Centre for the Southern Interior Radiation Therapy Research Program, Vancouver Centre VIC Radiotherapy, Vancouver Island VIC Systemic Therapy, Vancouver Island The Agency has five clinical locations: Vancouver Centre, Abbotsford, Fraser Valley (in Surrey), Vancouver Island (in Victoria), and Southern Interior (in Kelowna). It contains a number of units important to the clinical and preclinical infrastructure in B.C., as shown in Figure A1. Details of the six clinical trials units (CTUs) are given below. Brief information on the Advanced Therapeutics Investigational Drug Program and Tumour Tissue Repository can be found in Appendix 12 and Table 7 of the main text. BCCA Centre for the Southern Interior, Clinical Trials Unit The BCCA’s Centre for the Southern Interior is based in Kelowna (www.bccancer.bc.ca/RS/Centreforthe- SouthernInterior/). It is the centre of cancer research, education, prevention, diagnosis and treatment
CLINICAL TRIALS AND PRECLINICAL INFRASTRUCTURE ASSET MAP 53 in the Southern Interior of B.C. The Centre has 16 Principal Investigators as listed below, and 4 Associate Investigators. It has a matrix structure as shown in Figure A2. The facility has no independent URL. The Unit conducts Phases I, II, and III clinical trials. They accrue approximately 150 patients per year. The Principal Investigators at the Centre for the Southern Interior are as follows. Their details can be found in Appendix 6. • Czerkawski, Barbara • Mohamed, Islam • Delorme, Mike • Petrik, David • Ellard, Susan • Rao, Sanjay • Fyles, Gillian • Reed, Melanie • Halperin, Ross • Salhus, Terje • Hoegler, David • Sauciuc, Delia • Khoo, Kong • Sutherland, Judy • Kim, David • Taylor, Marianne Unit staffing is as follows: Study Nurses 1 Data Managers/ Coordinators Pharmacy Staff Laboratory Staff Administration 3.9 4.6 1 6 1.6 Potential clinical trials at the Centre are reviewed by a Clinical Trials Committee in the first instance. If approved, an application for study approval is submitted to the UBC-BCCA Research Ethics Board. FIGURE A2. Structure of the Centre for the Southern Interior CTU Director Clinical Operations PPL Pharmacy Regional Medical Leader PI’s Administrator Radiation Therapists Pharmacist Nurses Data Coordinators Unit Clerk Laboratory Technician Secretary Pharmacy Technician Quality control/ assurance procedures are based on BCCA Standard Operating Procedures compliant with Good Clinical Practice guidelines. All research staff are trained appropriately in GCP. Contact: Broughton, Sandra. Regional Administrator. Tel: 250-712-3903. sbroughton@bccancer.bc.ca. 1 Study nurses at CTUs/ centres, and study sites generally perform the role of a clinical research coordinator (defined as a link between a clinical trial sponsor, the investigator, and the study site), as well as conducting activities such as patient management, hands-on patient care, REB submissions, regulatory documentation and coordination, training of assistants, etc).
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