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T-piece:
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The first figure shows the connections from the mouthpiece in the direct system to the NO analyser,
the CO2 analyser, the pressure analyser and the chart recorder. The second figure shows the t-piece
connection allowing additional measurement of flow.
6.5.3 Ethics and Consent
The studies received prospective approval by the Royal Brompton Hospital Ethics Committee
and informed consent was obtained from each of the volunteer subjects.
6.5.4 The subjects
In total, twenty healthy volunteers (mean age 35.9 years, range 18-52 years, 9 males) took
part in these methodological studies. Following consent, each subject completed a
questionnaire (see Appendix 2). The subjects were non-atopic with no history of respiratory
or cardiac disease and taking no medication. All had normal spirometry (Compact
Vitalograph, Vitalograph Ltd, Buckingham, United Kingdom). Two female subjects involved
in the variable flow and variable pressure experiments smoked two cigarettes per day; the rest
were nonsmokers.
6.5.5 Statistical analvsis
The results were analysed using the Statistical Products and Services Solutions, (Package U
7.0, SPSS Inc, Chicago, USA). This employs the Student's t-test for matched pairs with mean,
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