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(see Figure 8.1). The following assessments used peak exhaled NO levels in keeping with our
work in adults.
The mean level of NO measured by direct exhalation into the analyser was 49.6 ppb' (SD
37.8, range lt.s-lgl.2ppb). The mean level of No measured via the t-piece system was29'7
ppb, (SD 2'7.1, range 5.I-t4l.2ppb). The reduction of the exhaled NO peak seen between the
two systems with the higher flow required for the t-piece measurement was consistent in all
subjects and consistent with the results in the adult experiments (see Figure 8'1)'
Figure 8.1: Peak exhaled NO results in healthy children
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comparison of the peak exhaled No results in the direct to analyser and the t-piece sampling system
in 39 healthy children with each data point being a mean of five exhalations'
There was no significant difference between the direct mean NO levels in boys at 43'lppb
(SD 40.5, range ll.5-lg7.2ppb) and girls with mean NO of 55.2 ppb (SD 35'4, runge 17 '7-
124.gppb, p=0.43). There was also no significant difference between the t-piece mean NO
levels in boys at 25.6ppb (SD 2g.z,range 7.3-L4l.2ppb) and girls with mean NO 33'8ppb (SD
25.l,range 5'l-g4'3 PPb, p=0'11)' (see Figure 8'2a and 8'2b)'
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