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Taylor, D. A., J. L. McGrath, et al. (1998). "Allergen-induced early and late asthmatic responsesarenotaffectedbyinhibitionofendogenouSnitricoxide.''@l of Respiratory & Critical Care Medicine 15E(l): 99-106. Taylor, D. A., J. L. McGrath, et al. (1998). "Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-monophosphate in asthma." Thorax 53(6): 483-9. Taylor, E. S., A. D. Smith, et al. (2004). "Effect of caffeine ingestion on exhaled nitric oxide measurements in patients with asthma." Care Medicine 169(9): l0l9-21. Taylor, I. K., A. A. Hill, et al. (1996). "Imaging allergen-invoked airway inflammation in atopic asthma with ll8F]-fluorodeoxyglucose and positron emission tomography." Lancet 347(9006): 937 -40. Taylor, I. K., R. Wellings, et al. (1992). "Urinary leukotriene E4 excretion in exercise-induced asthma." Journal of Applied Physiology 73(2):743-8. Te Puni Kokiri. (2002). "Maori Children Factsheet." from http://www.tpk. govt.nzlmaori/population/fschildren.pdf. Teeter,J.G.andE.R.Bleecker(1996).''Mechanismsofasthma.''@ Pulmonary Medicine 2(l): 23-8. ten Brinke, A., C. de Lange, et al. (2001). "Sputum induction in severe asthma by a standardized protocol: predictors of excessive bronchoconstriction." American Journal of Respiratory & Critical Care Medicine 164(5): 749-53. ten Hacken, N. H., H. van der Vaart, et al. (1998). "Exhaled nitric oxide is higher both at day and night in subjects with nocturnal asthma." Critical Care Medicine 158(3): 902-7. Teper, A. M., A. J. Colom, et al. (2004). "Effects of inhaled fluticasone propionate in children less than 2 years old with recurrent wheezing." Pediatric Pulmonology 37(2): 111-5. Terada, A., T. Fujisawa, et al. (2001). "Exhaled nitric oxide decreases during exerciseinduced bronchoconstriction in children with asthma." American Journal of Respiratory & Critical Care Medicine 164(10 Pt l): 1879-84. Texereau, J., I. Fajac, et al. (2005). "Reduced exhaled NO is related to impaired nasal potential difference in patients with cystic fibrosis." Vascular Pharmacolog], 43(6): 385-9. Therminarias, A., P. Flore, et al. (1998). "Air contamination with nitric oxide: effect on exhaled nitric oxide response." American Journal of Respiratory & Critical Care Medicine. Mar:157(3 Pt l):791-5. Thom, S. R., Y. A. Xu, et al. (1997). "Vascular endothelial cells generate peroxynitrite in response to carbon monoxide exposure." Chemical Research in Toxicology 10(9): r023-3r. Thoma-Uszynski, S., S. Stenger, et al. (2001). "Induction of direct antimicrobial activity through mammalian toll-like receptors." Science 291(5508): l5M-7. Thomas, P. S., P. G. Gibson, et al. (2005). "The relationship of exhaled nitric oxide to ainvay inflammation and responsiveness in children." Journal of Asthma 42(4):291-5. Thomas, P. S., D. H. Yates, et al. (1999). "Sputum induction as a method of analyzing pulmonary cells: reproducibility and acceptability." Journal of Asthma 36(a): 33541'. Thomas, S. R., S. A. Kharitonov, et al. (2000). "Nasal and exhaled nitric oxide is reduced in adult patients with cystic fibrosis and does not correlate with cystic fibrosis genotype." Chest lL7():1085-9. Thompson, A. B., H. Teschler, et al. (1996). "Preparation of bronchoalveolar lavage fluid with microscope slide smears." European Respiratory Journal 9(3): 603-8. Thurston, G. D., M. Lippmann, et al. (1997). "Summertime haze air pollution and children with asthma." American Journal of Respiratory & Critical Care Medicine 155(2):654- 60. 345
Tierney, W. M., J. F. Roesner, et al. (2004). "Assessing symptoms and peak expiratory flow rate as predictors of asthma exacerbations." Journal of General Internal Medicine 19(3):237-42. Timonen, K. L., J. Nielsen, et al. (1997). "Chronic respiratory symptoms, skin test results, and lungfunctionaspredictorsofpeakflowvariability.'' & Critical Care Medicine 156(3 ft 1): 776-82. Tinkelman, D.G., C. E. Reed, et al. (1993). "Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children." Bgliatlrics 92(l):64-77. Todokoro, M., H. Mochizuki, et al. (2003). "Childhood cough variant asthma and its relationship to classic asthma." Annals of Allergy. Asthma. & Immunology 90(6): 652-9. Toelle, B. G. and F. S. F. Ram (2004). "Cochran Review: Written individualised management plansforasthmainchildrenandadults.''@(l):1-28. Tomerak, A. A., J. J. McGlashan, et al. (2005). "Inhaled corticosteroids for non-specific chronic cough in children." Cochrane Database of Systematic Reviews(4): CD00a23l, Tomerak, A. A., H. Vyas, et al. (2005). "Inhaled beta2-agonists for treating non-specific chronic cough in children." (3): CD005373. Tonnel, A. B., P. Gosset, et al. (2001). "Characteristics of the Inflammatory response in bronchiallavagefluidsfrompatientswithstatusasthmaticus.''@ of Allergy & Immunology l?A(L-3):267-71. Torres, J., V. Darley-Usmar, et al. (1995). "Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration." Biochemical Journal 312(Pt l): 169-73. Touloumi, G., K. Katsouyanni, et al. (1997). "Short-term effects of ambient oxidant exposure on mortality: a combined analysis within the APFIEA project. Air Pollution and Health: aEuropean Approach." American Journal of Epidemiology 146(2): L77-85. Townley, R. G., A. K. Bewtra, et al. (1979). "Methacholine inhalation challenge studies." Journal of Allergy & Clinical Immunology 64(6 pt2): 569-74. Tracey, W. R., J. Linden, et al. (1990). "Comparison of spectrophotometric and biological assays for nitric oxide (NO) and endothelium-derived relaxing factor (EDRF): nonspecificity of the diazotization reaction for NO and failure to detect EDRF." Journal of Pharmacology & Experimental Therapeutics 252(3):922-8. Tran, D. D., J. J. Visser, et al. (1993). "Enhanced systemic nitric oxide production in inflammatory bowel disease." Lancet 341(8853): 1150. Trigg, C. J., N. D. Manolitsas, et al. (I99Q. "Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma." American Journal of Respiratory & Critical Care Medicine 150(1): 17-22. Trolin, G., T. Anden, et al. (1994). "Nitric oxide (NO) in expired air at rest and during exercise." Acta Physiologica Scandinavica. Jun:151(2): 159-63. Tsai, A. (1994). "How does NO activate hemeproteins?" EEBS-L&!E!g 341(2-3):141-5. Tsai, Y. G., M. Y. I-ee, et al. (2001). "A single dose of nebulized budesonide decreases exhaled nitric oxide in children with acute asthma." Journal of Pediatrics 139(3): 433- 7. Tsang, K. W., S. K. Ip, et al. (2001). "Exhaled nitric oxide: the effects of age, gender and body size." Lung 179(2):83-91. Tsang, K. W., R. Irung, et al. (20O2). "Exhaled and sputum nitric oxide in bronchiectasis : correlation with clinical parameters." ehes! 121(l): 88-94. Tsikas, D. (2004). "Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry." Methods in Molecular Biology 279:8L-LO3. Tsikas, D. (2005). "Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids." Free Radical Research 39(8): 797-815. 346
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UNIVERSITV OF AUCKI'AND Abstract -
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There was no significant difference
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This is Dedicated: Dedication To th
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New Zealand The Paediatric Departme
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Contents Abstract ........tr Dedica
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6.5.4 The subjects............... .
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XIV
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List of Figures Figure l.l: Top l0
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List of Abbreviations ABPA allergic
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LADA N*N* dimethyl L-arginine LFA1
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t}ryem(eNoS)Typeltrendothelialnifti
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area, some of it has been expanded
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In addition, both of these groups a
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studies conducted throughout the Un
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Video clips of infants with a varie
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the Paediatric Society of New 7*ala
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inhaled anti-cholinergic agents and
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ecommended to monitor asthma at hom
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improvement to 70Vo PEF would have
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Furthermore, investigators have als
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poorer predictor of a diagnosis of
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Bronsky et al. 1998), and a long-te
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SIGN guideline (SIGN 2005) stated "
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In brief, the human airway can be d
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The ability to biopsy has led to st
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small proportion of cells recovered
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methodology of sputum induction and
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et al. 1999; Giannini, Di Franco et
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over a six month treatment prograrn
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There are other studies suggesting
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So is induced sputum in adults and
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asymptomatic patients independent o
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onchial hyper-responsiveness (Reich
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led to research which looked for le
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analyser machines. This thesis pres
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The pollution of the 'great smog of
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adults greater than 65 years (Ostro
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levels compared to those children l
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More recently 'Air Quality Indexes'
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acetylcholine. These were known to
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cyclase does not produce significan
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Garthwaite l99l), and the non adren
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significant complication, this trea
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locus for the enzyme is a susceptib
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NO synthesis and in so doing blocke
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3.1 Chapter 3: The synthesis, react
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BHa = tetrahyrobiopterin, FAD = fla
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(Knowles, McWeeny et al. 1974) and
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more potent at low oxygen tensions
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toxic products such as isoprostanes
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Figure 3.3: The nitric oxide syntha
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providing NO as a neurotransmitter
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The enzyme of this second pathway -
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inappropriate production from comme
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Nicotinamide adenosine dinucleotide
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enzyme and are competitively revers
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4.1 Introduction Chapter 4: Methods
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4.4 Nitrite and nitrate The measure
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insensitive (Braker and Mossman 197
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A group of instruments have been de
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The original group demonstrated tha
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equired it. For example, there was
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helium for 30 minutes to remove Oz.
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(Postlethwait and Bidani 1990; Post
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is set at 5ppm (AIHA 1966) based on
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5.1 Chapter 5: Methodological asses
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wanted to compare the patterns of e
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in different colours that became th
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an advisor for this work and main s
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Delay time: the time between turnin
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led to an increased water content t
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Chapter 6: Methodological studies o
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pulmonary circulation appeared to c
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al found levels of 10.3ppb compared
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Authors and Pap€r Sublect numbers
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only those measured by mouth or low
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6. Check that the pens work. Fill w
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keys but it is currently in the mid
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Calibration pressures: the test por
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T-piece: tO The first figure shows
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the rotameter. Tracings of each par
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Figure 6.6: Mean exhaled NO levels
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NO and COz results from single exha
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6.6.4 (iii) Comparison of exhaled n
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Figure 6.11b: COz levels at peak NO
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I also considered whether the diffe
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the direct to the indirect method l
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need for methodological experiments
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The exhalations were carried out in
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Figure 7.2: Example of the tracing
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7.4.4 Results There was an increase
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Table 7.3: NO, COz and duration of
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The second set of exhalations invol
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Figure 7.6: Photographs of the chan
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Table 7.5: Exhaled NO results with
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the NO concentrations taken pre and
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Figure 7.10: Hyperbolic relationshi
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pressure over the likely range enco
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subjects with respiratory disease,
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8.1 Chapter 8: Exhaled nitric oxide
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standard error of the mean (SEM), s
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T-piece sampling system to analyser
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Figure 8.2a: Comparison of peak exh
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if yes who? if yes who? if yes who?
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There are limitations with regard t
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significantly between research grou
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controls. Kharitinov et al reported
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direct method in asthmatic children
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Figure 8.4a: The eftect of commenci
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had last used her p2 agonist inhale
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higher level of exhaled NO at 4.9pp
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9.1 Introduction Chapter 9: Exhaled
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For the oral measurements options i
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Table 9.1: The recommended standard
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taken from the available literature
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compartment correlated with the ser
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measurement with variable expirator
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to settle. We may have been measuri
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9.5 Off-line measurement NO determi
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(Hyde, Geigel et al. 1997; Tsoukias
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9.6 Nasal nitric oxide measurement
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measured over two 24 hour periods,
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women who coincidently experienced
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While these cross-sectional and the
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symptoms. Steroid response was sign
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'difficult asthma' also had higher
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season and then reduced down to bas
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of cross sectional studies with a t
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Ciabattoni et al. 2004; Petersen, A
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FEV9.5, symptom score and airways r
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Indomethacin - This medication alte
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89Vo for PCD, and above that exclud
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This low NO occurs despite higher t
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patients were followed through one
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differences noted based on filter,
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9.L6 Nitric oxide levels in exercis
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another study of 111 school childre
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Almost all studies used sedation, w
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peak exhaled NO production in the f
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flow and to minimize nasal contamin
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ecruit blood vessels in the lung. S
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Chapter 10: Reflections The outcome
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and I enrolled 52 asthmatic childre
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Edwards EA, Douglas C, Broome S, Je
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o Cass Byrnes & Nicky Holt. "Drugs
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o Byrnes CA. Paediatric fibreoptic
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Appendix 2: Questionnaire for enrol
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Al-Ali, M. K. and P. H. Howarth (20
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Archer, S. L., P. J. Shultz, et al.
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Baraldi, E., N. M. Azzolin, et al.
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Belda, J., P. Hussack, et al. (2001
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Bongers, T. and B. R. ODriscoll (20
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Brown, G. C. and C. E. Cooper (1994
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Castro-Rodriguez, J. A., C. J. Holb
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Cockcroft, D. W., D. N. Killian, et
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de Blic, J., V. Marchac, et al. (20
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Donaldson, S. H., W. D. Bennett, et
Page 317 and 318: Emi-Miwa, M., A. Okitani, et al. (1
Page 319 and 320: Frey, U., J. Stocks, et al. (2000).
Page 321 and 322: Gershman, N. H., H. Liu, et al. (19
Page 323 and 324: Grasemann, H., E. Michler, et al. (
Page 325 and 326: Hashimoto, T., K. Minoguchi, et al.
Page 327 and 328: Holgate, S. T., D. E. Davies, et al
Page 329 and 330: Iriso, R., P. M. Mudido, et al. (20
Page 331 and 332: Jones, A. W., M. Fransson, et al. (
Page 333 and 334: Kercsmar, C. M. (2006). Wheezing in
Page 335 and 336: Kleinert, H., T. Wallerath, et al.
Page 337 and 338: Lamblin, C., P. Gosset, et al. (199
Page 339 and 340: Li, X. and J. W. Wilson (1997). "In
Page 341 and 342: Lymar, S. V. and J. K. Hurst (1996)
Page 343 and 344: Massaro, A. F., S. Mehta, et al. (1
Page 345 and 346: Miyabara, Y., R. Yanagisawa, et al.
Page 347 and 348: contribute to impaired endothelium-
Page 349 and 350: ODell, T. J., R. D. Hawkins, et al.
Page 351 and 352: Panza, J. A., C. E. Garcia, et al.
Page 353 and 354: Peters, S. P. (2006). "Safety of in
Page 355 and 356: Prieto, L., L. Bruno, et al. (2003)
Page 357 and 358: Ribbons, K. A., X. J. Zhang, et al.
Page 359 and 360: Sacco, O., R. Sale, et al. (2003).
Page 361 and 362: Sessa, W. C., K. Pritchard, et al.
Page 363 and 364: Silvestri, M., F. Sabatini, et al.
Page 365 and 366: Stamler, J. S. (1994). "Redox signa
Page 367: Stuehr, D. J., N. S. Kwon, et al. (
Page 371 and 372: Upchurch, G. R., G. N. Welch, et al
Page 373 and 374: Wadsworth, R., E. Stankevicius, et
Page 375 and 376: Williams, O., R. Y. Bhat, et al. (2
Page 377 and 378: Yates, D. H., S. A. Kharitonov, et
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