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Mottu, F., A. Laurent, et al. (2000). "Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxiciiy data." Pda Journal of Pharmaceutical Science & Technology 54(6): 456-69. tutuo*ay, I. s. uno n.'1. retty (2000). "ozone and the lung: a sensitive issue." Molecular Aspects of Medicine 2l(I-2): I-48. Muller, B.J. gutttt, "t ul. (1992). 'iStructural and functional impairm.n! surfactant protein 9l A after exposure to nitrogen dioxide in rats." American Journal of Physiology 263(2Pt I):L177-84. Mulligan, M. S., J. M. Hevel, et al. (1991). "Tissue injury caused by deposition of immune complexes is L-arginine dependent." Proceedings of the National Academy of Sciences of the United States of America 88(1a): 6338-42' tututtigan, tnt. s, r.-s. wurr"n, et al. (1992). "Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine." Journal of Immunology 148(10): 3086-92. Munder, M., K. Eichmann, et al. (1999). "Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells." Journal of Immunology 163(7): 3771-7. Munoz-Fern andez,M. A., M. n. Fernandez, et al. (1992). "Synergism between tumor necrosis factor-alpha and interferon-garnma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism." European Journal of Immunology 22(2):30L-7. Munze[,-H. Suy"gh, ul. (igqSl. "Evidence for enhanced vascular superoxide anion production in nittutr "t tolerance. A novel mechanism underlying tolerance and crossiolerance." Journal of Clinical Investigation 95(1): 187-94. Muranaka, M., S. Suzuti, et ul. (1974). "Bronchial reactivity to acetycholine and IgE levels in asthmatic subjects after long-term remissions." Journal of Allergy and Clinical Immunology 54:32-40. tntu.pt y, t"t. g. una-E. Noack (1994). "Nitric oxide assay using hemoglobin method." Methods in Enzymolo gY 233: 240-50. tvturrayll. l,-A. B.Fonnel, et al. (1986). "Release of prostaglandin D2 into_human ainvays during acute antigen challenge." New England Journal of Medicine 315(13): 8004. Myers, p. R; R. L. Miior, Jr., et d. (fgqO). "Vasorelaxant properties of the endotheliumderived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide." Nature 345(627 l): 161-3. Nuguruki, ,t, t. Gotoh, et al. (1996). "Coinduction of nitric oxide synthase, argininosuccinate synthetase, and argininosuccinate lyase in lipopolysaccharide-treated rats. RNA blot' immunoblot, and immunohistochemical analyses." Journal of Biological Chemistr.v 271(5):2658-62. Najafi, N., C. Demanet, et al. (2003). "Differential cytology of bronchoalveolar lavage fluid in asthmatic children." @ 35(a): 302-8' Nakano, H., H. Ide, et al. (ZO0O). "ieduced nasal nitric oxide in diffuse panbronchiolitis." Am J Respir Crit Care Med 162(6):2218-20. Nakano, T., H. 1."tuto, ut. (2003). "DNA-protein cross-link formation mediated by oxanine. A novel genotoxic "t mechanism of nitric oxide-induced DNA damage." Journal of Biological Chemistry 27 8(27 ): 25264-7 2. Nupi",,ffi(2005).''Methodologicalissuesrelatedtoexhalednitricoxide measurement in children aged four to six yeats." Pediatric Pulmonolog)' 40(2):97- 104. Narang, I., R. Ersu, et al. (2002). "Nitric oxide in chronic airway inflammation in children: - diagnostic use and pathophysiological significance." @ 57 (7): 586-9' Naruse, K; K. Shimizu, et al: (1994). "Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not 323
contribute to impaired endothelium-dependent relaxation." Arteriosclerosis & Thrombosis 14(5): 7 46-52. Nathan, C. (1992). "Nitric oxide as a secretory product of mammalian cells." FASEB Journal 6(12):305r-64. Nathan, C. (1992). "Nitric oxide as a secretory product of mammalian cells. [Review] [162 refsl.' FASEB Journal. Sep:6(12):305 1-64. Nathan, C. (1997). "Inducible nitric oxide synthase: what difference does it make?' Journal of Clinical Investigation 100(10): 2417 -23. Nathan, C. and Q. W. Xie (1994). "Nitric oxide synthases: roles, tolls, and controls." @!! 78(6): 915-8. Nathan, C. and Q. W. Xie (1994). "Regulation of biosynthesis of nitric oxide." Journal of Biological Chemistry 269(19): L37 25-8. Nathan, C. F. and J. B. Hibbs, Jr. (1991). "Role of nitric oxide synthesis in macrophage antimicrobial activity." 3(1):65-70. National Asthma Education and Prevention Program (1997). Expert panel report 2: Guidelines for the diagnosis and management of asthma. Bethesda, Maryland, USA, National Institutes of Health: Publication no. 97-4051. National Heart Blood and Lung Institute (1991). "National Asthma Education Program: expert panel report: guidelines for the diagnosis and management of asthma." Journal of Allergy and Clinical Immunology 88: 425-534. National Heart Lung and Blood Institute (1991). Statement of technical standards for peak flow meters. National Asthma Education Program. Bethesda, USA: 4th February. Naylor, B. (1962). "The shedding of the mucosa of the bronchial tree in asthma." Thorax 17: 69-72. Nazir, 2., S. Razaq, et al. (2005). "Revisiting the accuracy of peak flow meters: a doubleblindstudyusingformalmethodsofagreement.''@99(5):592-5. Nel, A. E., D. Diaz-Sanchez, et al. (2001). "The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress." Current Opinion in Pulmonar.v Medicine 7(l):20-6. Nelson, B. V., S. Sears, et al. (1997). "Expired nitric oxide as a marker for childhood asthma." Journal of Pediatrics. Mar: 130(3):423-7. Ng, D., N. Kokot, et al. (1998). "Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, activator protein-l, andantioxidantresponseelements.''@|6t(2):942-5|. Nguyen, H., E. Finkelstein, et al. (2001). "Cigarette smoke impairs neutrophil respiratory bursr activation by aldehyde-induced thiol modifications." Toxicology 160(l-3):207- 17. Nicholson, B., C. K. Manner, et al. (2001). "Sustained nitric oxide production in macrophages requires the arginine transporter CNl2." Journal of Biological Chemistry 276(L9): 15881-5. Nicolai, T. (1999). "Air pollution and respiratory disease in children: what is the clinically relevant impact?" Pediatric Pulmonology - Supplement 18: 9-13. Nicolai, T., S. illi, et al. (1998). "Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence." @ 53(12): 1035-40. Niggemann, B., M. Ertel, et al. (1996). "Relevance of serum ECP measurements for monitoringacuteasthmainchildren.''J@433(5):327-30. Nightingale, J. A., D. F. Rogers, et al. (1998). "Effect of repeated sputum induction on cell counts in normal volunteers." ]fhorax,53(2): 87-90. Nightingale, J. A., D. F. Rogers, et al. (1998). "Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects." Thorax 53(7): 563-71. Niimi, A. and H. Matsumoto (1999). "Serum measurement of eosinophil cationic protein in the management of asthma." Cunent Opinion in Pulmonary Medicine 5(2): lll-7. 324
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UNIVERSITV OF AUCKI'AND Abstract -
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There was no significant difference
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This is Dedicated: Dedication To th
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New Zealand The Paediatric Departme
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Contents Abstract ........tr Dedica
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6.5.4 The subjects............... .
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XIV
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List of Figures Figure l.l: Top l0
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List of Abbreviations ABPA allergic
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LADA N*N* dimethyl L-arginine LFA1
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t}ryem(eNoS)Typeltrendothelialnifti
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area, some of it has been expanded
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In addition, both of these groups a
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studies conducted throughout the Un
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Video clips of infants with a varie
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the Paediatric Society of New 7*ala
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inhaled anti-cholinergic agents and
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ecommended to monitor asthma at hom
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improvement to 70Vo PEF would have
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Furthermore, investigators have als
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poorer predictor of a diagnosis of
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Bronsky et al. 1998), and a long-te
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SIGN guideline (SIGN 2005) stated "
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In brief, the human airway can be d
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The ability to biopsy has led to st
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small proportion of cells recovered
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methodology of sputum induction and
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et al. 1999; Giannini, Di Franco et
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over a six month treatment prograrn
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There are other studies suggesting
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So is induced sputum in adults and
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asymptomatic patients independent o
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onchial hyper-responsiveness (Reich
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led to research which looked for le
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analyser machines. This thesis pres
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The pollution of the 'great smog of
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adults greater than 65 years (Ostro
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levels compared to those children l
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More recently 'Air Quality Indexes'
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acetylcholine. These were known to
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cyclase does not produce significan
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Garthwaite l99l), and the non adren
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significant complication, this trea
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locus for the enzyme is a susceptib
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NO synthesis and in so doing blocke
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3.1 Chapter 3: The synthesis, react
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BHa = tetrahyrobiopterin, FAD = fla
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(Knowles, McWeeny et al. 1974) and
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more potent at low oxygen tensions
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toxic products such as isoprostanes
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Figure 3.3: The nitric oxide syntha
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providing NO as a neurotransmitter
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The enzyme of this second pathway -
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inappropriate production from comme
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Nicotinamide adenosine dinucleotide
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enzyme and are competitively revers
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4.1 Introduction Chapter 4: Methods
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4.4 Nitrite and nitrate The measure
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insensitive (Braker and Mossman 197
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A group of instruments have been de
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The original group demonstrated tha
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equired it. For example, there was
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helium for 30 minutes to remove Oz.
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(Postlethwait and Bidani 1990; Post
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is set at 5ppm (AIHA 1966) based on
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5.1 Chapter 5: Methodological asses
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wanted to compare the patterns of e
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in different colours that became th
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an advisor for this work and main s
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Delay time: the time between turnin
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led to an increased water content t
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Chapter 6: Methodological studies o
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pulmonary circulation appeared to c
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al found levels of 10.3ppb compared
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Authors and Pap€r Sublect numbers
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only those measured by mouth or low
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6. Check that the pens work. Fill w
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keys but it is currently in the mid
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Calibration pressures: the test por
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T-piece: tO The first figure shows
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the rotameter. Tracings of each par
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Figure 6.6: Mean exhaled NO levels
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NO and COz results from single exha
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6.6.4 (iii) Comparison of exhaled n
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Figure 6.11b: COz levels at peak NO
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I also considered whether the diffe
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the direct to the indirect method l
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need for methodological experiments
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The exhalations were carried out in
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Figure 7.2: Example of the tracing
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7.4.4 Results There was an increase
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Table 7.3: NO, COz and duration of
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The second set of exhalations invol
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Figure 7.6: Photographs of the chan
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Table 7.5: Exhaled NO results with
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the NO concentrations taken pre and
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Figure 7.10: Hyperbolic relationshi
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pressure over the likely range enco
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subjects with respiratory disease,
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8.1 Chapter 8: Exhaled nitric oxide
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standard error of the mean (SEM), s
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T-piece sampling system to analyser
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Figure 8.2a: Comparison of peak exh
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if yes who? if yes who? if yes who?
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There are limitations with regard t
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significantly between research grou
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controls. Kharitinov et al reported
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direct method in asthmatic children
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Figure 8.4a: The eftect of commenci
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had last used her p2 agonist inhale
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higher level of exhaled NO at 4.9pp
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9.1 Introduction Chapter 9: Exhaled
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For the oral measurements options i
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Table 9.1: The recommended standard
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taken from the available literature
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compartment correlated with the ser
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measurement with variable expirator
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to settle. We may have been measuri
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9.5 Off-line measurement NO determi
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(Hyde, Geigel et al. 1997; Tsoukias
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9.6 Nasal nitric oxide measurement
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measured over two 24 hour periods,
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women who coincidently experienced
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While these cross-sectional and the
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symptoms. Steroid response was sign
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'difficult asthma' also had higher
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season and then reduced down to bas
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of cross sectional studies with a t
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Ciabattoni et al. 2004; Petersen, A
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FEV9.5, symptom score and airways r
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Indomethacin - This medication alte
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89Vo for PCD, and above that exclud
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This low NO occurs despite higher t
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patients were followed through one
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differences noted based on filter,
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9.L6 Nitric oxide levels in exercis
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another study of 111 school childre
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Almost all studies used sedation, w
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peak exhaled NO production in the f
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flow and to minimize nasal contamin
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ecruit blood vessels in the lung. S
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Chapter 10: Reflections The outcome
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and I enrolled 52 asthmatic childre
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Edwards EA, Douglas C, Broome S, Je
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o Cass Byrnes & Nicky Holt. "Drugs
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o Byrnes CA. Paediatric fibreoptic
Page 295 and 296: Appendix 2: Questionnaire for enrol
Page 297 and 298: Al-Ali, M. K. and P. H. Howarth (20
Page 299 and 300: Archer, S. L., P. J. Shultz, et al.
Page 301 and 302: Baraldi, E., N. M. Azzolin, et al.
Page 303 and 304: Belda, J., P. Hussack, et al. (2001
Page 305 and 306: Bongers, T. and B. R. ODriscoll (20
Page 307 and 308: Brown, G. C. and C. E. Cooper (1994
Page 309 and 310: Castro-Rodriguez, J. A., C. J. Holb
Page 311 and 312: Cockcroft, D. W., D. N. Killian, et
Page 313 and 314: de Blic, J., V. Marchac, et al. (20
Page 315 and 316: Donaldson, S. H., W. D. Bennett, et
Page 317 and 318: Emi-Miwa, M., A. Okitani, et al. (1
Page 319 and 320: Frey, U., J. Stocks, et al. (2000).
Page 321 and 322: Gershman, N. H., H. Liu, et al. (19
Page 323 and 324: Grasemann, H., E. Michler, et al. (
Page 325 and 326: Hashimoto, T., K. Minoguchi, et al.
Page 327 and 328: Holgate, S. T., D. E. Davies, et al
Page 329 and 330: Iriso, R., P. M. Mudido, et al. (20
Page 331 and 332: Jones, A. W., M. Fransson, et al. (
Page 333 and 334: Kercsmar, C. M. (2006). Wheezing in
Page 335 and 336: Kleinert, H., T. Wallerath, et al.
Page 337 and 338: Lamblin, C., P. Gosset, et al. (199
Page 339 and 340: Li, X. and J. W. Wilson (1997). "In
Page 341 and 342: Lymar, S. V. and J. K. Hurst (1996)
Page 343 and 344: Massaro, A. F., S. Mehta, et al. (1
Page 345: Miyabara, Y., R. Yanagisawa, et al.
Page 349 and 350: ODell, T. J., R. D. Hawkins, et al.
Page 351 and 352: Panza, J. A., C. E. Garcia, et al.
Page 353 and 354: Peters, S. P. (2006). "Safety of in
Page 355 and 356: Prieto, L., L. Bruno, et al. (2003)
Page 357 and 358: Ribbons, K. A., X. J. Zhang, et al.
Page 359 and 360: Sacco, O., R. Sale, et al. (2003).
Page 361 and 362: Sessa, W. C., K. Pritchard, et al.
Page 363 and 364: Silvestri, M., F. Sabatini, et al.
Page 365 and 366: Stamler, J. S. (1994). "Redox signa
Page 367 and 368: Stuehr, D. J., N. S. Kwon, et al. (
Page 369 and 370: Tierney, W. M., J. F. Roesner, et a
Page 371 and 372: Upchurch, G. R., G. N. Welch, et al
Page 373 and 374: Wadsworth, R., E. Stankevicius, et
Page 375 and 376: Williams, O., R. Y. Bhat, et al. (2
Page 377 and 378: Yates, D. H., S. A. Kharitonov, et
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