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individual subjects (see Figure 7 .2 for an example of the recording on one subject)' The mean
decrease in exhaled NO was 35ppb (957o C| 25.7,43.4) from the expiratory flow rate of
25omls/min to ll0omls/min. There were no significant differences in the mean CO2 levels,
mean mouth pressure (controlled) or mean duration of exhalation in the measurements made
at the differing flow rates. There was no difference between the first baseline and repeated
baseline of NO when the expiratory flow was the same (p-0.9 95Vo CI -16'9, 17'0), excluding
an order effect (see Table 7.2).
Table 7.1: NO, COz and duration of each exhalation at different expiratory flows
NO is measured as peak NO in parts per billion, COz is measured as peak aq the percentage of
QOz
total gases, duration is measured in seconds. Lach result is the mean of five exhalations for every
subject. a. Duratn = duration of exhalation.
Figure 7.1: Exhaled NO results with increasing expiratory flows
160
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.E 120
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t
,i 20
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250 mls/mln 500 mlr/mln 750 mle/mln 1100 mlr/mln
Sublect Gender Age NO COz Durtn' NO COz Durtn NO COz Durtn NO COr Durtn
1 Female 32 23 4.7 57 17 4.5 59 23 4.5 55 4.5 50
2 Male 33 102 7.2 52 89 7.0 55.0 73 6.3 55 TI 6.2 51
3 Male 37 78 6.0 56 68 6.1 56 60 5.9 62 51 5.9 62
4 Male 49 85 6.4 66 70 5.7 59 79 5.8 62 70 6.0 61
c Female 43 31 6.2 55 23 6.2 54 19 5.8 54 17 6.0 54
6 Female 32 147 6.2 63 115 6.1 64 100 6.2 68 92 6.1 63
7 Female 37 83 5.7 50 86 5.8 52 82 5.9 47 76 6.0 44
8 Female 35 143 6.4 71 127 6,2 7',| 95 5.2 67 85 6.2 69
9 Male 43 67 6.7 84 60 6.9 72.1 43 2.0 71.0 38 7.0 71
10 Female 36 30 6.1 58 24 6.0 57 18 5.9 55 15 5.8 50
L
__ F.-f
2g 500 7s0
Explratory flows In mls/mln
Mean peak exhaled No levels at different expiratory flows for ten individuals (six females). Each point
is the mean of five exhalations.
t57
------
a
11(n