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Figure g.3b: Mean peak exhaled No levels in control and asthmatic children measured via the t-piece
sampling system
lt 150
g o.
.g
:/ 100
a-
a
':r
-i i !
!!!
normals
asthmatics
bronchodilhlor
therapy only
mean
and SEM
aslhmatics
regular lnhaled
cortioostsroids
Mean peak exhaled NO levels in healthy children (n=39), asthmatics on bronchodilator therapy only
(n=15) and asthmatic children on regular IHCS therapy (n=16) measured by the t'piece sampling
system. Note the Y scale is discontinuous to accommodate the outliers'
There were no differences in the CO2 levels, mouth pressures, and durations of expiration
between the different groups or between the two methods within each group as noted in Table
8.2.
Six asthmatic children on bronchodilator treatment only but deemed clinically to require the
introduction of IHCS therapy to improve their asthma control were recruited for the
longitudinal study. Prior to commencing steroids the median exhaled NO was 1245ppb
(range 67.6-330.6ppb). Following treatment for two weeks on either budesonide diproprionate
4001t"gtwice per day in five subjects or budesonide diproprionate 2}}ltgtwice per day in one
subject all delivered via a Turbohaler@, NO fell to a median level of 48.6ppb (range 36'8-
153.6ppb). This reflected a decrease in all the children with only one subject now having a
different result from that observed in normal children (see Figures 8.4a and 8'4b)'
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