Références bibliographiques Niezen, J.H., Waghorn, T.S., Charleston, W.A., Waghorn, G.C., 1995, Growth and <strong>gastro</strong>intestinal nemato<strong>de</strong> parasitism in lambs grazing either lucerne (Medicago sativa) or sulla (Hedysarum coronarium) which contains con<strong>de</strong>nsed tannins. J Agric Science 125, 281-289. Niezen, J.H., Robertson, H.A., Waghorn, G.C., Charleston, W.A., 1998a, Production, faecal egg counts and worm bur<strong>de</strong>ns of ewe lambs which grazed six contrasting forages. Vet Parasitol 80, 15-27. Niezen, J.H., Waghorn, G.C., Charleston, W.A., 1998b, Establishment and fecundity of Ostertagia circumcincta and Trichostrongylus colubriformis in lambs fed lotus (Lotus pedunculatus) or perennial ryegrass. Vet Parasitol 78, 13-21. Niezen, J.H., Waghorn, G.C., Graham, T., Carter, J.L., Leathwick, D.M., 2002, The effect of diet fed to lambs on subsequent <strong>de</strong>velopment of Trichostrongylus colubriformis larvae in vitro and on pasture. Vet Parasitol 105, 269-283. O'Donnell, I.J., Dineen, J.K., Wagland, B.M., Letho, S., Werkmeister, J.A., Ward, C.W., 1989a, A novel hostprotective antigen from Trichostrongylus colubriformis. Int J Parasitol 19, 327-335. O'Donnell, I.J., Dineen, J.K., Wagland, B.M., Letho, S., Dophei<strong>de</strong>, T.A., Grant, W.N., Ward, C.W., 1989b, Characterization of the major immunogen in the excretory-secretory products of exsheathed third-stage larvae of Trichostrongylus colubriformis. Int J Parasitol 19, 793-802. Onah, D.N., Nawa, Y., 2000, Mucosal immunity against parasitic <strong>gastro</strong>intestinal nemato<strong><strong>de</strong>s</strong>. Korean J Parasitol 38, 209-236. Outteridge, P.M., Windon, R.G., Dineen, J.K., 1985, An association between a lymphocyte antigen in sheep and the response to vaccination against the parasite Trichostrongylus colubriformis. Int J Parasitol 15, 121- 127. Outteridge, P.M., Windon, R.G., Dineen, J.K., Smith, E.F., 1986, The relationship between ovine lymphocyte antigens and faecal egg count of sheep selected for responsiveness to vaccination against Trichostrongylus colubriformis. Int J Parasitol 16, 369-374. Outteridge, P.M., Windon, R.G., Dineen, J.K., 1988, An ovine lymphocyte antigen marker for acquired resistance to Trichostrongylus colubriformis. Int J Parasitol 18, 853-858. Owen, R.L., 1994, M cells--entryways of opportunity for enteropathogens. J Exp Med 180, 7-9. Paterson, S., Wilson, K., Pemberton, J.M., 1998, Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population. Proc Natl Acad Sci U S A 95, 3714-3719. Paterson, K.A., McEwan, J.C., Dodds, K.G., Morris, C.A., Crawford, A.M., 2001, Fine mapping a locus affecting host resistance to internal parasites in sheep. Proceedings of the Association for Advancement in Animal Breeding and Genetics, Queenstown, New-Zeland 13, 91-94. Paul, W.E., Se<strong>de</strong>r, R.A., 1994, Lymphocyte responses and cytokines. Cell 76, 241-251. Pennock, J.L., Behnke, J.M., Bickle, Q.D., Devaney, E., Grencis, R.K., Isaac, R.E., Joshua, G.W., Selkirk, M.E., Zhang, Y., Meyer, D.J., 1998, Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. Biochem J 335 ( Pt 3), 495-498. Pernthaner, A., Vlassoff, A., Douch, P.G., Maass, D.R., 1997, Cytokine mRNA and IFN-g production in nemato<strong>de</strong> resistant and susceptible line lambs artificially infected with <strong>gastro</strong>-intestinal nemato<strong><strong>de</strong>s</strong>. Acta Parasitologica 42, 55-61. Pernthaner, A., Cole, S.A., Morrison, L., Hein, W.R., 2005, Increased expression of interleukin-5 (IL-5), IL-13, and tumor necrosis factor alpha genes in intestinal lymph cells of sheep selected for enhanced resistance to nemato<strong><strong>de</strong>s</strong> during infection with Trichostrongylus colubriformis. Infect Immun 73, 2175-2183. 226
Références bibliographiques Pfeffer, A., Douch, P.G., Shaw, R.J., Gatehouse, T.K., Rabel, B., Green, R.S., Shirer, C.L., Jonas, W.E., Bisset, S., 1996, Sequential cellular and humoral responses in the abomasal mucosa and blood of Romney sheep dosed with Trichostrongylus axei. Int J Parasitol 26, 765-773. Piper, L.R., 1987, Genetic variation in resistance to internal parasites, In: McGuirk, B.J. (Ed.) Merino Improvement Program In Australia, Australian Wool Corporation.Sydney, pp. 351-363. Poppi, D.P., Sykes, A.R., Dynes, R.A., 1990, The effect of endoparasitism on host nutrition - the implications for nutrient manipulation. Proceed New Zealand Soc Animal Prod 50, 237-243. Prichard, R.K., 1973, The fumarate reductase reaction of Haemonchus contortus and the mo<strong>de</strong> of action of some anthelmintics. Int J Parasitol 3, 409-417. Prichard, R.K., 1990, Anthelmintic resistance in nemato<strong><strong>de</strong>s</strong>: extent, recent un<strong>de</strong>rstanding and future directions for control and research. Int J Parasitol 20, 515-523. Pritchard, D.I., Quinnell, R.J., Walsh, E.A., 1995, Immunity in humans to Necator americanus: IgE, parasite weight and fecundity. Parasite Immunol 17, 71-75. Prichard, R., 2001, Genetic variability following selection of Haemonchus contortus with anthelmintics. Trends Parasitol 17, 445-453. Quinnell, R.J., 2003, Genetics of susceptibility to human helminth infection. Int J Parasitol 33, 1219-1231. Quinnell, R.J., Pritchard, D.I., Raiko, A., Brown, A.P., Shaw, M.A., 2004, Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection. J Infect Dis 190, 430-438. Radhakrishnan, C.V., Bradley, R.E., Sr., Loggins, P.E., 1972, Host responses of worm-free Florida native and Rambouillet lambs experimentally infected with Haemonchus contortus. Am J Vet Res 33, 817-823. Rainbird, M.A., Macmillan, D., Meeusen, E.N., 1998, Eosinophil-mediated killing of Haemonchus contortus larvae: effect of eosinophil activation and role of antibody, complement and interleukin-5. Parasite Immunol 20, 93-103. Ramos-Vara, J.A., Miller, M.A., Lopez, E., Prats, N., Brevik, L., 1994, Reactivity of polyclonal human CD3 antiserum in lymphoid tissues of cattle, sheep, goats, rats and mice. Am J Vet Res 55, 63-66. Raynaud, J.P., 1970, Etu<strong>de</strong> <strong>de</strong> l'efficacité d'une technique <strong>de</strong> coproscopie quantitative pour le diagnostic <strong>de</strong> routine et le contrôle <strong><strong>de</strong>s</strong> infestations parasitaires <strong><strong>de</strong>s</strong> bovins, équins et porcins. Ann Parasitol Hum Comp 45, 321-342. Rhoads, M.L., Fetterer, R.H., Hill, D.E., Urban, J.F., Jr., 2000, Trichuris suis: a secretory chymotrypsin/elastase inhibitor with potential as an immunomodulator. Exp Parasitol 95, 36-44. Roberts, F.H.S., Turner, H.N., Mckervett, M., 1954, On the specific distinctness of the ovine and bovine strains of Haemonchus contortus (Rudolphi) Cobb (Nematoda: Trichostrongylidae). Aust J Zool 2, 275-295. Robertson, H.A., Niezen, J.H., Waghorn, G.C., Charleston, W.A., Jinlong, M., 1995, The effect of six herbages on liveweight gain, wool growth and faecal egg count of parasitized ewe lambs. Proceed New Zealand Soc Animal Prod 55, 199-201. Romagnani, S., 1997, The Th1/Th2 paradigm. Immunol Today 18, 263-266. Romjali, E., Pan<strong>de</strong>y, V.S., Batubara, A., Gatenby, R.M., Verhulst, A., 1996, Comparison of resistance of four genotypes of rams to experimental infection with Haemonchus contortus. Vet Parasitol 65, 127-137. Rothwell, T.L., 1989, Immune expulsion of parasitic nemato<strong><strong>de</strong>s</strong> from the alimentary tract. Int J Parasitol 19, 139-168. 227
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