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stiinte med 3 2011.indd - Academia de Ştiinţe a Moldovei

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Ştiinţe Medicale<br />

in cardiovascular diseases. Clin Chem Lab Med 2004;<br />

42:1085–91.<br />

7. Lee DH, Steffen LM, Jacobs DR. Association<br />

between serum gamma-glutamyltransferase and dietary<br />

factors: CARDIA study. Am J Clin Nutr 2004; 79(4):<br />

600-5.<br />

8. Whitfield JB. Gamma-Glutamyl transferase. Crit<br />

Rev Clin Lab Sci 2001; 38:263–355.<br />

9. Karlson BW, Wiklund O, Hallgren P, Sjolin M,<br />

Lindqvist J, Herlitz J. Ten-year mortality amongst patients<br />

with a very small or unconfir<strong>med</strong> acute myocardial<br />

infarction in relation to clinical history, metabolic screening<br />

and signs of myocardial ischemia. J Intern Med, 2000; 247:<br />

449–456.<br />

10. Rantala AO, Lilja M, Kauma H, Savolainen<br />

MJ, Reunanen A, Kesaniemi YA. Gamma-glutamyl<br />

transpeptidase and the metabolic syndrome. J Intern Med,<br />

2000; 248: 230–238, 2000.<br />

11. Nilssen O, For<strong>de</strong> OH, Brenn T. The Tromso<br />

Study. Distribution and population <strong>de</strong>terminants of gammaglutamyltransferase.<br />

Am J Epi<strong>de</strong>miol. 1990;132:318<br />

–326.<br />

12. Ruttmann E, Brant LJ, Concin H, Diem G, Rapp<br />

K, Ulmer H. Gammaglutamyltransferase as a risk factor<br />

for cardiovascular disease mortality: an epi<strong>de</strong>miological<br />

investigation in a cohort of 163 944 Austrian adults.<br />

Circulation. 2005;112:2130 –2137.<br />

13. Marchesini G, Brizi M, Bianchi G, Tomassetti S,<br />

Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani<br />

G, Melchionda N: Nonalcoholic fatty liver disease: a<br />

feature of the metabolic syndrome. Diabetes, 2001; 50:<br />

1844 –1850.<br />

14. Marchesini G, Forlani G: NASH: from liver<br />

diseases to metabolic disor<strong>de</strong>rs and back to clinical<br />

hepatology. Hepatology, 2002; 35:497– 499.<br />

15. Malnick SD, Beergabel M, Knobler H: Nonalcoholic<br />

fatty liver: a common manifestation of a metabolic<br />

disor<strong>de</strong>r. QJM, 2003; 96: 699 –709.<br />

16. Ortega E, Koska J, Salbe AD, Tataranni PA,<br />

Bunt JC. Related Articles, Links Serum gamma-glutamyl<br />

transpeptidase is a <strong>de</strong>terminant of insulin resistance<br />

in<strong>de</strong>pen<strong>de</strong>ntly of adiposity in Pima Indian children. J Clin<br />

Endocrinol Metab. 2006; 91:1419 –1422.<br />

17. Expert Panel on Detection, Evaluation, and<br />

Treatment of High Blood Cholesterol in Adults: Executive<br />

Summary of The Third Report of The National Cholesterol<br />

Education Program (NCEP) Expert Panel on Detection,<br />

Evaluation, and Treatment of High Blood Cholesterol in<br />

Adults (Adult Treatment Panel III). JAMA, 2001; 285:<br />

2486 –2497.<br />

18. Karp DR, Shimooku K, Lipsky PE. Expression<br />

of gamma-glutamyl transpeptidase protects Ramos B cells<br />

from oxidation-induced cell <strong>de</strong>ath. J Biol Chem 2001; 276:<br />

3798–804.<br />

19. Paolicchi A, Emdin M, Ghliozeni E, Ciancia E,<br />

Passino C, Popoff G, Pompella A. Human atherosclerotic<br />

plaques contain gamma-glutamyl transpeptidase enzyme<br />

activity. Circulation. 2004;109:1440.<br />

20. Paolicchi A, Minotti G, Tonarelli P et al.<br />

Gammaglutamyltranspeptidase-<strong>de</strong>pen<strong>de</strong>nt iron<br />

347<br />

reduction and LDL oxidation: a potential mechanism in<br />

atherosclerosis. J Invest Med 1999; 47: 151–60.<br />

21. Dominici S, Valentini M, Maellaro E et al. Redox<br />

modulation of cell surface protein thiols in U937 lymphoma<br />

cells: the role of gamma-glutamyl transpeptidase-<strong>de</strong>pen<strong>de</strong>nt<br />

H2O2 production and S-thiolation. Free Radic Biol Med,<br />

1999; 27:623–35.<br />

22. Ross R. Mechanism of disease: Atherosclerosis<br />

— an inflammatory disease. N Engl J Med 1999; 340:115–<br />

26.<br />

23. Mitchinson MJ. Toxicity of oxidized LDL towards<br />

mouse peritoneal macrophages in vitro. Atherosclerosis<br />

1993; 98:17–24.<br />

24. Rajagopalan S, Meng XP, Ramasamy S, Harrison<br />

DG, Galis ZS. Reactive oxygen species produced by<br />

macrophage-<strong>de</strong>rived foam cells regulate the activity of<br />

vascular matrix metalloproteinases in vitro. J Clin Invest<br />

1996; 98:2572–9.<br />

25. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum<br />

A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J,<br />

Lisheng L, for the INTERHEART Study Investigators.<br />

Effect of potentially modifiable risk factors associated with<br />

myocardial infarction in 52 countries (the INTERHEART<br />

study): casecontrol study. Lancet. 2004; 364:937–952.<br />

26. Mason JE, Starke RD, Van Kirk JE. Gamma-<br />

Glutamyl Transferase: A Novel Cardiovascular Risk<br />

BioMarker. Prev Cardiol. 2010;13:36–41.<br />

Abstract<br />

Gamma-glutamyltransferase is an established liver<br />

function test and a sensitive marker of hepatic inflammation.<br />

Recent studies have focused increasing attention on the<br />

usefulness of GGT as a predictor of cardiovascular disease.<br />

As a result, i<strong>de</strong>ntifying higher than expected GGT levels<br />

should alert the physician to study patients more <strong>de</strong>tailed,<br />

with the hopeful outcome of preventing unnecessary<br />

cardiac-related events and <strong>de</strong>aths in future years.<br />

Rezumat<br />

Gamma-glutamiltransferaza (GGT) se consi<strong>de</strong>ră ca<br />

un test funcţional hepatic şi marker sensibil al inflamaţiei<br />

hepatice. Studiile recente au atenţionat privind utilitatea<br />

GGT ca fiind factor predicator al patologiei cardiovasculare.<br />

Determinarea nivelului ridicat al GGT impune studierea<br />

<strong>de</strong>tailată a pacientului cu scopul prevenirii evenimentelor<br />

cardiovasculare şi mortalităţii în anii succesivi.<br />

Резюме<br />

Гамма-глутамилтрансфераза (ГГТ) является признанным<br />

печёночным тестом и чувствительным<br />

маркером печеночного воспаления. В последних исследованиях<br />

все большее внимание было сосредоточено<br />

на использовании ГГТ как предиктора сердечнососудистых<br />

заболеваний. Таким образом, определение<br />

повышенного уровня ГГТ должно побудить врача для<br />

детального исследования пациента с целью предотвращения<br />

развития сердечно-сосудистых осложнений и<br />

смерти в последующие годы.

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