Title: Alternative Sweeteners

Overview 11
the maximum dietary level of an additive demonstrating no toxic effects, a ‘‘no
observable effect level’’ or NOEL. The NOEL is then used to determine the ADI.
For example, if safety evaluation studies of a given substance demonstrate a
NOEL of 1000 mg/kg, using a 100-fold safety factor the ADI would be 10 mg/
kg body weight per day for humans.
The ADI does not represent a maximum allowable daily intake level. It
should not be regarded as a specific point at which safety ends and possible health
concerns begin. In fact, the U.S. FDA has said it is not concerned that consumption
occasionally may exceed the ADI. The agency has stressed that because the
ADI has a built-in safety margin and is based on a chronic lifetime exposure,
occasional consumption in amounts greater than the ADI ‘‘would not cause adverse
effects’’ (15).
VII. CONCLUSION
Low-calorie products are in demand and consequently so are the ingredients that
make them possible. With recent approvals more and more good-tasting products
will become available. In the near future, additional products that are reduced in
fat and calories, incorporating both fat replacers and low-calorie and reducedcalorie
sweeteners are expected. With the increase in obesity in many parts of
the world and as consumers become increasingly aware that ‘‘calories still
count,’’ the number of successful light products should soar.
REFERENCES
1. Light Products Usage and Weight Control Habits Survey. Conducted by Booth Research
Services, Inc. for the Calorie Control Council, March, 1998.
2. J Rice, et al. Rodent tumors of urinary bladder, renal cortex, and thyroid gland in
IARC monographs evaluations of carcinogenic risk to humans. Toxicol Sci 49:166–
171, 1999.
3. JA Desor, O Maller, LS Green. Preference for sweet in humans. In: JM Weiffenbach,
ed. Infants, Children and Adults in Taste and Development: The Genesis of Sweet
Preference. Washington, DC: U.S. Department of Health, Education, and Welfare,
1977, p 171.
4. A Drewnowski. Sweetness and obesity. In: J Dobbing, ed. Sweetness. Berlin:
Springer-Verlag, 1987.
5. Joint FAO/WHO Expert Committee on Food Additives. Toxicological Evaluation
of Certain Food Additives with a Review of General Principles and Specifications.
Geneva: World Health Organization, 1974.
6. Codex Alimentarius Commission. Procedural Manual. Rome: 5th ed. Food and Agricultural
Organization of the United Nations, 1981, p 21.