Title: Alternative Sweeteners

498 Fry and Hoek
rally, there is no reason the salt cannot be used in any application permitted by
regulation, including liquid beverages and dairy products.
The salt is made from existing, permitted intense sweeteners. Its manufacture
even purifies further the food-grade raw materials, and the process introduces
no new impurities. The salt is stable on dry storage, including at elevated temperatures,
and dissociates immediately when dissolved to provide an equimolar solution
of aspartame and acesulfame. Thus, toxicologically, there is no difference
between aspartame-acesulfame salt and an equimolar, mechanical mixture of
aspartame and acesulfame-K, and use of the salt introduces no new toxicological
issues. The salt is regarded in the United States as being covered by current FDA
regulations on aspartame and acesulfame-K, and regulatory clearance is being
sought in numerous other countries.
Aspartame-acesulfame, its production, and many applications are the subjects
of international patents and patent applications by Holland Sweetener Company,
which markets the sweetener-sweetener salt under their trademark Twinsweet.
REFERENCES
1. DA Palomo Coll. Procedimiento para la preparación de nuevas sales fisiológicamente
activas o aceptables de sabor dulce. Spanish Patent ES-A-8 604 766, 1986.
2. JC Fry, J Van Soolingen. Sweetener salts. European Patent Application EP 0 768
041, 1997.
3. JC Fry, J Van Soolingen. Sweetener salts. United States Patent US-A-5827562,
1998.
4. JC Fry. Two in one—an innovation in sweeteners. Proceedings of 1996 International
Sweeteners Association Conference: Sweeteners. Openings in an Expanding European
Market, Brussels, 1996, pp 58–68.
5. AC Hoek, LFW Vleugels, C Groeneveld. Improved powder mix quality with Twinsweet
in Low-Calorie Sweeteners: Present and Future, Proceedings of ISA/IUFoST
World Conference on Low-Calorie Sweeteners, Barcelona, 1999, Ed. A Conti.
Karger, Basel, 1999, pp 133–139.
6. JC Fry. Two in one—an innovation in sweeteners. Proceedings of the 45th Annual
Conference of the International Society of Beverage Technologists, Savannah GA,
1998, pp 83–92.
7. JC Fry, AC Hoek, AE Kemper. Chewing gums containing dipeptide sweetener with
lengthened and improved flavour. International Patent Application WO-98/02048-
A, 1998.
8. A Hoek, J Fry. Aspartame-acesulfame salt: an innovation in sweetness. Proceedings
of Food Ingredients Europe, London, 1997, pp 55–57.
9. JC Fry, AC Hoek, LFW Vleugels. Dry foodstuffs containing dipeptide sweetener.
International Patent Application WO-98/02050-A, 1998