Title: Alternative Sweeteners

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Acesulfame K 27 All methods described allow the separation of acesulfame K from other intense sweeteners that may be used in combination. VI. REGULATORY SITUATION The completion of a comprehensive safety evaluation program paved the way for the approval of acesulfame K as a food additive. The evaluation of the data by the Joint Expert Committee for Food Additives of the WHO and FAO resulted in approval for food use with the allocation of an ADI of 0–15 mg/kg of body weight (23). In addition, specifications were published that were revised later (52). The Scientific Committee for Foods of the EEC performed another evaluation of acesulfame’s safety. Again, acesulfame was approved for food use, and an ADI of 0–9 mg/kg of body weight was allocated (24). In the United Kingdom, the first country approving Acesulfame, the Food Additives and Contaminants Committee published a report on sweetening agents for foods, listing acesulfame K among ‘‘substances that the available evidence suggests are acceptable for use in food’’ (53). In the United States, the approval of acesulfame for a number of applications was granted in 1988 (25) followed by approvals for many other product categories including soft drinks. All approvals allow use of acesulfame K under conditions of good manufacturing practice (i.e., without numerical limitation) (54). After the favorable assessments published by the WHO and FAO and the Scientific Committee for Foods of the EU, more than 100 countries have approved the use of acesulfame K in at least some products. They include all member states of the European Union (because acesulfame K is listed for many applications in the Directive on <strong>Sweeteners</strong> for Use in Foodstuffs), Canada, Japan, Australia, and New Zealand. In several countries, approvals according to good manufacturing practice have been granted. Because the ADI values allocated for acesulfame K may not be easy to compare with use levels, a conversion into the corresponding sucrose levels offers a simple possibility to get an idea of the potential applications. Using the sweetness intensity factor of 200 times sucrose, the ADI allocated by the WHO and FAO corresponds to 180 g of sucrose for the 60-kg adult. These values are well above the average daily sucrose consumption. Therefore, it can be concluded that the intake of acesulfame K will generally be well below the ADI. This view has been confirmed by intake studies and calculations. REFERENCES 1. K Clauss, H Jensen. Oxathiazinon dioxides—a new group of sweetening agents. Angew Chem Engl 85:965, 1973; Angew Chem (Int Ed), 12:869, 1973.
28 von Rymon Lipinski and Hanger 2. K Clauss, E Lück, G-W von Rymon Lipinski. Acetosulfam, ein neuer Süssstoff. Z Lebensm Unters Forsch 162:37, 1976. 3. H-J Arpe. Acesulfame K, a new noncaloric sweetener. In: B Guggenheim, ed. Health and Sugar Substitutes. Proceeding of the ERGOB Conference, Geneva 1978. Basel: Karger, 1978, p 178, and personal communications. 4. G-W von Rymon Lipinski, BE Huddart. Acesulfame K Chem Ind 1983: 427. 5. European Patent 1 59 516 (22.03.1984) to Hoechst AG. 6. EF Paulus. 6-Methyl-1,2,3-oxathiazin-4(3H)-on 2,2-dioxide. Acta Cryst (B) 31: 1191, 1975. 7. K Hoppe, B Gassmann. Vergleichstabellen zur Süsseintensität von 16 Süßungsmitteln. Lebensmittelindustrie 32:227, 1985. 8. DB Ott, CL Edwards, SJ Palmer. Perceived taste intensity and duration of nutritive and non-nutritive sweeteners in water using time-intensity (T-I) evaluations. J Food Sci 56:535, 1991. 9. K Paulus, M Braun. Süsskraft und Geschmacksprofil von Süssstoffen. Ernährungs- Umschau 35:384, 1988. 10. K Hoppe, B Gassmann. Neue Aspekte der Süsskraftbeurteilung und des Einsatzes von Süssungsmitteln. Nahrung 24:423, 1980. 11. U.S. Patent 4 158 068 (12.06.1979) to Hoechst AG. 12. RA Frank, SJ Mize, R Carter. An assessment of binary mixture interactions for nine sweeteners. Chem Senses 14:621, 1989. 13. N Ayya, HT Lawless. Quantitative and qualitative evaluation of high-intensity sweeteners and sweetener mixtures. Chem Senses, 17:245, 1992. 14. G-W von Rymon Lipinski, E Klein. Synergistic effects in blends of Acesulfame K and Aspartame. ACS Conference ‘‘<strong>Sweeteners</strong>—Carbohydrate and Low Calorie.’’ Los Angles, 1988, No. 27. 15. LY Hanger, G Ritter, R Baron. unpublished results. 16. AI Bakal. Functionality of combined sweeteners in several food applications. Chem Ind 18:700, 1983. 17. RC Gelardi. The multiple sweetener approach and new sweeteners on the horizon. Food Technol 41(1):123, 1987. 18. LY Hanger, A Lotz, S Lepeniotis. Descriptive profiles of selected high intensity sweeteners (HIS), HIS blends and sucrose. J Food Sci 61:456, 1996. 19. MO Portman, D Kilcast. Descriptive profiles of synergistic mixtures of bulk and intense sweeteners. Food Quality Preference, 9:221, 1998. 20. PV Tournot, J Pelgroms, JV DerMeeren. Sweetness evaluation of mixtures of fructose with saccharin, aspartame or acesulfame K. J Food Sci 50:469, 1985. 21. G-W von Rymon Lipinski. The new intense sweetener Acesulfame K. Food Chem 16:259, 1985. 22. Toxicological Evaluation of Certain Food Additives. WHO Food Additives Series, 16:11, 1980. 23. Evaluàtion of Certain Food Additives and Contaminants. Twenty-seventh Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series No. 696. Geneva, 1983, p 21; Evaluation of Certain Food Additives and Contaminants. Thirty-seventh Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series No. 806. Geneva 1991, p 20.
Page 3 and 4: ISBN: 0-8247-0437-1 This book is pr
Page 5 and 6: iv Preface these sweeteners are bei
Page 7 and 8: vi Contents 7. Tagatose 105 Hans Be
Page 10 and 11: Contributors Sue E. Andress The Nut
Page 12 and 13: Contributors xi Carolyn M. Merkel M
Page 14 and 15: 1 Alternative Sweeteners: An Overvi
Page 16 and 17: Overview 3 II. RELATIVE SWEETNESS P
Page 18 and 19: Overview 5 IV. INTERNATIONAL REGULA
Page 20 and 21: Overview 7 V. U.S. REGULATION OF SW
Page 22 and 23: Overview 9 General recognition of s
Page 24 and 25: Overview 11 the maximum dietary lev
Page 26 and 27: 2 Acesulfame K Gert-Wolfhard von Ry
Page 28 and 29: Acesulfame K 15 Figure 3 Acesulfame
Page 30 and 31: Acesulfame K 17 Figure 4 Sweetness
Page 32 and 33: Acesulfame K 19 The acute oral toxi
Page 34 and 35: Acesulfame K 21 Table 2 Stability o
Page 36 and 37: Acesulfame K 23 were preferred over
Page 38 and 39: Acesulfame K 25 losses during bakin
Page 42 and 43: Acesulfame K 29 24. Report of the S
Page 44 and 45: 3 Alitame Michael H. Auerbach Danis
Page 46 and 47: Alitame 33 IV. SOLUBILITY At the is
Page 48 and 49: Alitame 35 Figure 3 Alitame and asp
Page 50 and 51: Alitame 37 Figure 5 Metabolism of a
Page 52 and 53: Alitame 39 autonomic, gastrointesti
Page 54 and 55: 4 Aspartame Harriett H. Butchko, W.
Page 56 and 57: Aspartame 43 Figure 2 Principal con
Page 58 and 59: Aspartame 45 A wide range exists ov
Page 60 and 61: Aspartame 47 Figure 4 Dietary intak
Page 62 and 63: Aspartame 49 day for 60-kg adults (
Page 64 and 65: Aspartame 51 mood, and behavior (88
Page 66 and 67: Aspartame 53 VI. WORLDWIDE REGULATO
Page 68 and 69: Aspartame 55 30. A Bar, C Biermann.
Page 70 and 71: Aspartame 57 67. HH Butchko, C Tsch
Page 72 and 73: Aspartame 59 104. AF Stokes, A Belg
Page 74: Aspartame 61 144. D Squillacote. As
Page 77 and 78: 64 Bopp and Price Figure 1 Structur
Page 79 and 80: 66 Bopp and Price Table 1 Regulator
Page 81 and 82: 68 Bopp and Price V. ADMIXTURE POTE
Page 83 and 84: 70 Bopp and Price and thickeners (1
Page 85 and 86: 72 Bopp and Price XII. METABOLISM C
Page 87 and 88: 74 Bopp and Price sodium cyclamate
Page 89 and 90: 76 Bopp and Price ied during the pa
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78 Bopp and Price the studies invol
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80 Bopp and Price 0.42 µg/ml and w
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82 Bopp and Price 4. U.S. Patent No
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84 Bopp and Price 48. SM Sieber, RH
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6 Neohesperidin Dihydrochalcone Fra
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Neohesperidin Dihydrochalcone 89 Fi
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Neohesperidin Dihydrochalcone 91 Fi
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Neohesperidin Dihydrochalcone 93 in
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Neohesperidin Dihydrochalcone 95 ot
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Neohesperidin Dihydrochalcone 97 Ta
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Neohesperidin Dihydrochalcone 99 th
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Neohesperidin Dihydrochalcone 101 c
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Neohesperidin Dihydrochalcone 103 5
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7 Tagatose Hans Bertelsen and Søre
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Tagatose 107 the same type of Food
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Tagatose 109 in pigs according to m
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Tagatose 111 IV. USE OF D-TAGATOSE
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Tagatose 113 rinsing periods or dur
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Tagatose 115 anaerobic bacterial fe
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Tagatose 117 The intestines of both
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Tagatose 119 Table 1 Relative Sweet
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Tagatose 121 D. Hygroscopicity Taga
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Tagatose 123 Table 2 Heat of Soluti
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Tagatose 125 In conclusion, tagatos
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Tagatose 127 24. BB Jensen, B Buema
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130 Stargel et al. Figure 1 Compari
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132 Stargel et al. Figure 2 Matrix
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134 Stargel et al. ness of neotame
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136 Stargel et al. Figure 4 Taste p
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138 Stargel et al. Table 1 Solubili
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140 Stargel et al. study strains in
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142 Stargel et al. to 10,000 µg/pl
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144 Stargel et al. for general use
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9 Saccharin Ronald L. Pearson PMC S
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Saccharin 149 proved for use in the
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Saccharin 151 was added to sodium d
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Saccharin 153 Table 2 Economics of
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Saccharin 155 Table 4 Saccharin Adm
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Table 6 Flavor Profile and Cost Com
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Saccharin 159 Figure 5 Hydrolysis o
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Saccharin 161 malian repellant (52,
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Saccharin 163 REFERENCES 1. GE DuBo
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Saccharin 165 67. GP Schoenig, et a
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168 Kinghorn et al. herbarium speci
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170 Kinghorn et al. Figure 1 Struct
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172 Kinghorn et al. V. USE AND ADMI
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174 Kinghorn et al. sulting in the
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176 Kinghorn et al. Figure 2 Struct
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178 Kinghorn et al. iol administere
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180 Kinghorn et al. cus mutans, or
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182 Kinghorn et al. a natural sweet
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11 Sucralose Leslie A. Goldsmith an
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Sucralose 187 Figure 2 Sweeteness i
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Sucralose 189 cant difference was f
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Sucralose 191 fructose, and/or insu
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Sucralose 193 Figure 4 Sucralose so
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Sucralose 195 Figure 6 Viscosities
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Sucralose 197 Table 2 Sucralose Int
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Sucralose 199 tively, compared with
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Sucralose 201 Figure 10 Breakdown o
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Sucralose 203 Table 3 Percent Mass
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Sucralose 205 Table 4 Initial Appli
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Sucralose 207 4. Sucralose Safety A
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210 Kinghorn and Compadre establish
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212 Kinghorn and Compadre grosvenor
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214 Kinghorn and Compadre form. Phy
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216 Kinghorn and Compadre of the de
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218 Kinghorn and Compadre Figure 5
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226 Kinghorn and Compadre sweet tas
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230 Kinghorn and Compadre 5. O Tana
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232 Kinghorn and Compadre 41. S Nir
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13 Erythritol Milda E. Embuscado an
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Erythritol 237 The commercial produ
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Table 2 Properties of Erythritol Co
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Erythritol 241 used to obtain the d
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Erythritol 243 crose stabilized and
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Erythritol 245 Figure 4 (A) Rate of
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Table 6 Assessment Criteria for the
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Table 7 Summary of Pivotal Toxicity
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Erythritol 251 VI. FOOD AND PHARMAC
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Erythritol 253 5. C Servo, J Pabo,
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14 Hydrogenated Starch Hydrolysates
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Figure 1 (a) Chemical structures fo
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Hydrogenated Starch Hydrolysates an
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Page 276 and 277:
Page 278 and 279:
15 Isomalt Marie-Christel Wijers* P
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Isomalt 267 GPM depends on the isom
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Isomalt 269 IV. PHYSICO-CHEMICAL PR
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Isomalt 271 temperature than sucros
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Isomalt 273 C. Diabetics A number o
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Isomalt 275 Figure 7 Changes in wei
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Isomalt 277 C. Chewing Gum Sticks,
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Isomalt 279 isomalt is significantl
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Isomalt 281 der Sorbit-Toleranz ges
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16 Maltitol Kazuaki Kato Towa Chemi
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Maltitol 285 Like the other polyols
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Maltitol 287 of shape over time), h
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Maltitol 289 results of this confer
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Maltitol 291 available on certain p
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Maltitol 293 Table 3 Worldwide Stat
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Maltitol 295 alcohol. Unpublished r
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298 Mesters et al. Figure 1 The che
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300 Mesters et al. rium and equal m
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302 Mesters et al. sugars are then
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304 Mesters et al. Figure 2 Telemet
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306 Mesters et al. Figure 3 Moistur
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308 Mesters et al. Figure 6 Viscosi
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310 Mesters et al. tose are the mai
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312 Mesters et al. Figure 8 The wat
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314 Mesters et al. food containing
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18 Sorbitol and Mannitol Anh S. Le
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Sorbitol and Mannitol 319 Figure 2
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Table 1 Physical Properties of the
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Sorbitol and Mannitol 323 Figure 4
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Sorbitol and Mannitol 325 bases are
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Sorbitol and Mannitol 327 is used a
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Sorbitol and Mannitol 329 ‘‘cap
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Sorbitol and Mannitol 331 that mann
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Sorbitol and Mannitol 333 Mannitol
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19 Xylitol Philip M. Olinger Polyol
Page 350 and 351:
Xylitol 337 Milled forms of xylitol
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Xylitol 339 Table 2 Solubility of S
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Xylitol 341 tol in a fluoride tooth
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Xylitol 343 The recognition of xyli
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Xylitol 345 tion of the availabilit
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Xylitol 347 grow and metabolize opt
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Xylitol 349 VIII. USE OF XYLITOL AS
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Xylitol 351 IX. USE OF XYLITOL IN P
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Xylitol 353 Human tolerance of high
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Xylitol 355 29. CS Gong, TA Claypoo
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Xylitol 357 71. JDB Featherstone, T
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Xylitol 359 112. JS Van der Hoeven.
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Xylitol 361 tans omz 176 by xylitol
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Xylitol 363 BL Horecker, K Lang, Y
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Xylitol 365 of Certain Food Additiv
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368 White and Osberger II. MANUFACT
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370 White and Osberger scribe impro
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372 White and Osberger Figure 1 Cyc
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374 White and Osberger When asparta
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376 White and Osberger Table 5 Temp
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378 White and Osberger Figure 3 Met
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380 White and Osberger Figure 5 Com
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382 White and Osberger Table 6 Glyc
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384 White and Osberger Table 8 Low-
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386 White and Osberger F. Confectio
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388 White and Osberger In 1993, Vui
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390 White and Osberger 18. AL Forbe
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392 Buck Table 1 Market Division be
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394 Buck Table 3 World HFS Consumpt
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396 Buck Figure 3 Production of 42%
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398 Buck Table 4 Typical Characteri
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400 Buck Table 5 Effect of Temperat
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402 Buck Table 7 International Soci
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404 Buck Because of the high purity
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406 Buck VII. APPLICATIONS HFCS rep
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408 Buck is a benefit and in other
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410 Buck 1986. This evaluation conc
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22 Isomaltulose William E. Irwin* P
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Isomaltulose 415 Figure 2 Isosweet
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Isomaltulose 417 Figure 3 Solubilit
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Isomaltulose 419 Figure 6 Plasma in
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Isomaltulose 421 6. Dreissig VW, Lu
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424 Richards and Dexter various pla
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426 Richards and Dexter from assays
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428 Richards and Dexter desiccation
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430 Richards and Dexter 2. Taste Qu
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432 Richards and Dexter parative da
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434 Richards and Dexter Table 3 Com
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436 Richards and Dexter dissipate t
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438 Richards and Dexter unpublished
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440 Richards and Dexter IX. SHELF-L
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Figure 7 Egg white (95 g) was mixed
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444 Richards and Dexter Figure 10 B
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446 Richards and Dexter Figure 12 O
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448 Richards and Dexter Figure 14 T
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450 Richards and Dexter XIII. CARIO
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452 Richards and Dexter tions was s
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454 Richards and Dexter activity, a
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456 Richards and Dexter E. 14-day T
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458 Richards and Dexter 3. J Leibow
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460 Richards and Dexter 41. LM Crow
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24 Mixed Sweetener Functionality Ab
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Mixed Sweetener Functionality 465 2
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Mixed Sweetener Functionality 467 T
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Page 484 and 485:
Mixed Sweetener Functionality 471 F
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Page 488 and 489:
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Page 492 and 493:
Mixed Sweetener Functionality 479 I
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25 Aspartame-Acesulfame: Twinsweet
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Aspartame-Acesulfame: Twinsweet 483
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26 Polydextrose Helen Mitchell Dani
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Polydextrose 501 Table 1 Approximat
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Polydextrose 503 at 25°C. Polydext
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Polydextrose 505 Figure 4 Hygroscop
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Polydextrose 507 Table 5 Functional
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Polydextrose 509 F. Fiber Polydextr
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Polydextrose 511 providing bulk, mo
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Polydextrose 513 H. Soft Candy The
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Polydextrose 515 B. International T
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Polydextrose 517 chemical and econo
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520 Deis I. FAT IS ESSENTIAL AND FU
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522 Deis Figure 1 Ingredient suppor
Page 537 and 538:
524 Deis binding water, thus provid
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526 Deis The U.S. Department of Agr
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528 Deis stabilizer, thickener, or
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530 Deis mouth feel and rate of gel
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532 Deis Figure 4 Structure of glyc
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534 Deis Table 4 General Categories
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536 Deis ninths of the fat availabl
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538 Deis the same function in all f
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540 Deis 28. Anon. Glycerine: like
Page 555 and 556:
542 Index [Alitame] solubility, 33
Page 557 and 558:
544 Index [Erythritol] gastrointest
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546 Index [High fructose corn syrup
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548 Index Mogrosides, 211-213 prope
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550 Index [Polyols] isomalt, 265-28
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552 Index [Sucralose] safety, 189-1
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