Abstract Book - 3rd International Symposium on Medicinal Plants ...

The 3 rd <strong>International</strong> <strong>Symposium</strong> on Medicinal Plants, their Cultivation and Aspects of Uses
Topic (8): Industrial Utilization of Medicinal Plants
8.1 Development of Dental Gel of Complex Action «Aromadent Plus»
Composition and Technology
Baranova Inna, Lebedynets Olga, and Bespalaya Yuliya
National University of Pharmacy, Kharkiv, Ukraine.
<strong>Abstract</strong>: Gel is the rational medicinal form for periodontium topical therapy – it is well
distributed and absorbed by the mouth mucous membrane that provides high bioavailability of the
active ingredients. The interaction of the gel with mucous membranes improves the penetration of
components. The diffusion of active substances in the mouth cavity is decreased due to the
hydrogel viscosity, and moderate washing off by saliva allows saving the optimal concentration of
substances on the localized gum area. On the basis of complex studies conducted we have
chosen tea tree and eucalyptus essential oils as plant components which possess antibacterial,
anti-inflammatory, regenerative properties, and also sulphatized glycosaminoglycan (sodium
chondroitin sulphate) as anti-inflammatory, wound healing, and regenerative agent. As a result of a
complex of physical and chemical and technological studies a stable gel system on the basis of
hydroxyethylcellulose and other auxiliary substances was worked out. Addition of sorbitol in 10%
concentration provided a moderate osmotic activity of the stomatological gel. The microbiological
studies showed the addition of tea tree and eucalyptus essential oils (2% of each) to be rational as
the synergy of the antimicrobial activity displays. The optimal theurapeutic concentration of sodium
chondroitin sulphate (1,0 %) has been determined on the basis of biological studies. The modern
methods of qualitative and quantitative determination of sodium chondroitin sulphate (HPLC), tea
tree and eucalyptus essential oils (gas chromatography) were worked out for the proposed
medicinal preparation standardization. The proposed methods differ by their high sensitivity and
results‟ reproductivity. As a result of stability study of stomatological gel “Aromadent plus” the
expiration terms and storage conditions were determined – 2 years in aluminium tubes with
varnished cover at room temperature.
Pharmacological studies showed the remedy to have
expressed anti-inflammatory on the model of carrageenan oedema in mice. The active
components of the gel have been proven to be cyclooxygenase inhibitors and not to have a
serious impact on the leukotriene phase of inflammation on the zymosan oedema model in rats.
The presence of expressed reparative activity of the dental gel was proven on the model of linear
incised wounds in rats. The LD50 for the stomatological gel “Aromadent plus” exceeds 15000
mg/kg at intrastomachal introduction in rats which allows to attribute it to IV toxicity class –
relatively safe substances. On the basis of conducted pharmaco-technological, structural and
mechanical, physical and chemical, microbiological and other researches composition and
technology of gel «Aromadent plus» was proven.
Key words: Aromadent Plus, composition, dental Gel, technology.
8.2 Corrosion Inhibition by Limonium touhini (Plumbaginaceae) Extract in
Acid Medium
BENAHMED Merzoug 1 , LAFHAL M 2 ., DJEDDI N 1 ., AKKAL S 2 ., LAOUAR H. 3
1 Laboratoire des molécules actives et applications, Université Tébessa. 2 Laboratoire de
Phytochimie et Analyses physicochimiques et Biologiques, Département de Chimie, Faculté de
Sciences exactes, Université Mentouri Constantine, Route d’Ain el Bey, 25000 Constantine,.
3 Département de biologie, Université de Séti,f. Algérie
<strong>Abstract</strong>: The inhibition of the corrosion of C steel in 1 M HCl by Limonium touhinni has been
studied by weight loss, potentiodynamic polarization method and electrochemical impedance
spectroscopy measurements. The inhibition efficiency increased with increasing concentration of
the inhibitor. The results of weight loss studies correlated well with those of impedance and
polarization studies.
Key words: C steel, inhibition, electrochemical spectroscopy, Limonium touhinni.
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