Abstract Book - 3rd International Symposium on Medicinal Plants ...

1.86 Hepatoprotective and Hypolipidemic Effects of Red Ginseng Crude
Extract in Obese Rats.
Shalaby A. Mostafa and Hamouda A. Ashraf
Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box
12211, Egypt.
<strong>Abstract</strong>: The effects of red ginseng extract (RGE) on liver function, serum lipids and some
metabolic hormones were evaluated in obese rats. Sixty male rats were distributed into 6 equal
groups, each of 10 animals. Group (1) was fed on basal diet (normal control), while the other five
groups were fed on high fat-diet for 8 weeks to induce obesity. Group (2) was kept as an obese
control, while groups (3), (4), (5) and (6) were orally given RGE at 50, 100, 150 and 200 mg/kg-
1/day, respectively for 4 weeks. At the end of experiment, blood was collected from orbital
plexuses of veins and used for separating serum for estimation of some serum biochemical
constituents. Histological examination of the livers was also carried out. Results showed that RGE
significantly decreased the elevated levels of AST, ALT and ALP enzymes; reduced levels of TC,
TG and LDL. It increased serum levels of insulin and decreased leptin hormone in obese-treated
rats. RGE at the large dose (200 mg/kg-1) ameliorated the degenerative changes seen in liver of
obese rats. Red ginseng crude extract has hepatoprotective and hypolipidemic effects in obese
rats. Therefore, this study recommends that daily intake of red ginseng roots as a drink may be
useful for obese patients who suffer from liver diseases associated with hyperlipidemia.
Key words: Histopathology, hormones, obesity, lipid profile, liver enzymes, red ginseng.
1.87 Antibacterial and Antioxidant Activity of Some Medicinal Plant Extracts
Grown in South Jordan.
Sharaf Omar 1 , Khaled Al-tarawneh, and Husni Al-tawara,
1 Al-Balqa’ Applied University, Faculty of Agricultural Technology, Dep. Of Nutrition and Food
Processing. Jordan.
<strong>Abstract</strong>: The effect of methanol and ethanol of eleven plant extracts was tested against four
bacterial isolates: Escherichia coli, Staphylococcus aureus, Listeria monocytogenes and
Clostridium prerfirngens. The antibacterial activity against Gram positive bacteria was noticed with
extract from the following plants: Sarcopterum spinosum L Paronchia argentea Lam ,Artemisia
seiberi, Achillea fragrantissima (forssk) and Teucrium poliumL. The minimum inhibitory
concentration (MIC) for methanol plant extracts of S. spinosum against C. prerfirngens and S.
aureus was 0.25 mg/ml while the MIC for T. Polium and A. fragrantissima against L.
monocytogenes was 0.45 mg/ml. In ethanol extract the MIC was 0.20 mg/ml for S. spinosum
against C. prerfirngen and 0.45 mg/ml for A. fragrantissima and A. seiberi against L.
monocytogenes. The phenolic content in methanol and ethanol plant extracts were (8.5- 194.9)
and (12.1- 252.4) in mg Gallic acid equivalent (GAE) respectively. The extract of S. spinosum and
A. fragrantissima contained high and low amount of total phenolic compound respectively. A high
antioxidant activity was obtained with extracts of the following plants: S. spinosum, A.
fragrantissima, A. seiberi, T. Polium, Arum hygrophyllum (A. hygrophyllum) and Matricaria aurea
(Loefl.) (M. aurea). These extracts inhibited lipid peroxidation in the ratios near or reach the
inhibition of vitamin E. Finally there was low relation between antioxidant activity and phenolic
content.
Key words: Antibacterial, antioxidant, medicinal plant extracts, Clostridium prerfirngens,
Escherichia coli, Listeria monocytogenes, Staphylococcus aureus.
46