Abstract Book - 3rd International Symposium on Medicinal Plants ...

1 Sciences Chimiques de Rennes, Catalyse et Organométalliques, UMR 6226: CNRS–Université
de Rennes 1,Campus de Beaulieu, 35042 France Cedex. 2 département de chimie université
mentouri de Constantine 25000 Algérie.
<strong>Abstract</strong>: Among the alkaloids, the isoquinolines are known to be numerous, displaying a wide
range of biological activities; their structural diversity provided an impetus in an already fertile field
of researches aimed at controlling asymmetric centres. Methods for the asymmetric synthesis of
isoquinoline alkaloids have been reviewed by Chrzanowska and Rozwadowska and are based on
many synthetic strategies. In this context, analogue of Crispine A (4) has been also selected as
target compound. This pyrollo-isoquinoline alkaloid shows cytotoxic activity against HeLa human
cancer lines, whilst it‟s deoxygenated counterpart (–)-4 exhibit antidepressant activity. We report
on the synthesis of homochiral alkaloids 1–4 from α-aminonitrile. Homochiral (S)-(–)-αmethylbenzylamine
served as a source of nitrogen and chirality.
Acknowledgments: The authors wish to thank University of Rennes1 for providing research
facility and University of Constantine for financial support for the accomplishment of this work.
Key words: Alkaloid crispine, analogue, Carduus crispus, isolation.
3.29 Comparative GC Analysis of Seed Essential Oils from Tunisian and
German Caraway (Carum carvi L.) Ecotypes
LARIBI Bochra 1 , KOUKI K., 1 BETTAIEB T 1 ., MOUGOU A. 1 and MARZOUK B. 2
1 Institut National Agronomique de Tunis. 43, Av. Charles Nicolle-1082, Tunis, Tunisia.
2 Laboratoire des Substances Bioactives, CBBC, BP 901, 2050- Hammam-Lif, Tunisia.
<strong>Abstract</strong>: The seed essential oil composition of two caraway (Carum carvi L.) ecotypes from
Tunisia and Germany, cultivated under the same pedoclimatic and cultural conditions has been
analysed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS).
The essential oil yields differed significantly between the two caraway ecotypes: 1.41% and 0.48%
for Tunisian and German seeds, respectively. Forty one (41) volatile compounds were identified in
the two oil samples where carvone and limonene constituted the main components but with
significant different proportions. Consequently, the two caraway ecotypes displayed the same
chemotype, namely carvone. Additionally, the proportions of some minor essential oil compounds
such as ketones, oxygenated monoterpenes and sesquiterpenes were found to be significantly
different between the German caraway seed essential oil and the Tunisian one. Since the
influence of different environmental factors has been eliminated, the observed differences in seed
essential oil yield and composition between the two studied ecotypes seem likely to result from the
genetic variability.
Keywords: Carum carvi L, carvone, essential oil, limonene, seeds.
3.30 Strategy for the Valorization of Natural Products: Biological and
Chemical Evaluation of Plant Extracts (examples of Moroccan plants)
M. Hmamouchi
President of the Arab Federation of Medicinal and Aromatic Plants, Ex-Director of the National
Institute of Medicinal and Aromatic Plants in Morocco, Pr. Faculty of medicine and Pharmacy of
Rabat, Morocco.
<strong>Abstract</strong>: There are approximately 60,000 plant species in Arab /Africa countries, which
represent roughly a quarter of the world plants. Unfortunately, despite the wealth and endemicity
of the Arab plants biodiversity and associated cultures and these regions has only contributed 83
of the world‟s 1100 leading commercial medicinal plants. The world market for herbal medicines
based on traditional knowledge is estimated at over US$ 60 billion, which is about 30 percent of
80