INTRODUCCIÓN: REVISIÓN CRITICA DEL PROBLEMA

RESULTADOS
TABLA 1. Baseline characteristics
Sinus Rhythm Atrial fibrillation p Value
(n = 59)
(n = 38)
Sex (female) 35.0 35.1 0.989
Age (years) 67.6 ± 12.7 71.9 ± 9.3 0.062
Body mass index (Kg/m 2 ) 27.9 ± 4.2 29.2 ± 4.6 0.299
Diabetes mellitus 40.7 34.2 0.522
Dyslipidemia 52.5 52.8 0.982
Hypertension 50.8 70.3 0.060
Ischemic cardiopathy 35.0 27.0 0.413
Heart rate (bpm) 75.3 ± 15.2 75.3 ± 15.5 0.993
Renal failure 25.0 64.9 0.001
LDL-cholesterol (mg/dL) 111.6 ± 30.5 110.6 ± 42.0 0.904
HDL-cholesterol (mg/dL) 45.1 ± 20.8 40.8 ± 10.9 0.288
Fructosamine (mg/dL) 235.3 ± 53.1 276.6 ± 78.5 0.020
HbA1c 6.0 ± 0.9 6.8 ± 1.6 0.009
Fluorescent AGEs (a.u.) 61.8 ± 20.1 74.9 ± 25.6 0.006
sRAGE (ng/mL) 996.1 ± 820.7 1714.2 ± 1105.5 0.001
Left atrial area (cm 2 ) 23.3 ± 6.2 28.9 ± 6.9 0.001
Left atrial volume (cm 3 ) 54.8 ± 13.6 65.4 ± 8.4 0.002
LVEF < 50 % 76.7 60.6 0.103
ACEI/ARB 96.7 83.8 0.025
Insulin 10.0 13.5 0.596
Statins 51.7 37.8 0.185
ACEI/ARB: angiotensin converting enzyme inhibitors and angiotensin receptor blockers; AGEs: advanced
glycation end-products; HbA1c: glycated haemoglobin; LVEF: left ventricular ejection fraction; sRAGE:
soluble receptor for advanced glycation end-products.
TABLE 2. Comparison between SR and AF groups depending on the presence or absence of DM.
NON DIABETIC DIABETIC
SR AF p Value SR AF p Value
(n = 35) (n = 24)
(n = 25) (n = 13)
Sex (female) 28.6 29.2 0.960 44.0 46.2 0.899
Age (years) 64.8 ± 13.6 71.7 ± 9.5 0.028 71.4 ± 10.6 72.3 ± 9.1 0.775
Body mass index (Kg/m 2 ) 27.8 ± 4.4 29.6 ± 5.8 0.337 28.1 ± 4.1 28.6 ± 2.9 0.668
Dyslipidemia 44.1 39.1 0.708 64.0 76.9 0.333
Hypertension 32.4 70.8 0.004 76.0 69.2 0.468
Ischemic cardiopathy 22.9 29.2 0.585 52.0 23.1 0.085
Heart rate (bpm) 73.1 ± 16.5 70.9 ± 15.0 0.614 78.3 ± 12.9 84.1 ± 13.0 0.217
Renal failure 17.1 62.5 0.001 36.0 69.2 0.050
LDL-cholesterol (mg/dL) 119.7 ± 24.9 106.2 ± 35.9 0.135 99.2 ± 34.6 120.3 ± 54.1 0.197
HDL-cholesterol (mg/dL) 49.3 ± 24.5 41.6 ± 9.9 0.121 39.0 ± 12.0 39.1 ± 13.4 0.991
HbA1c 5.6 ± 0.6 5.8 ± 0.3 0.271 6.6 ± 1.1 8.4 ± 1.6 0.001
Fructosamine (mg/dL) 206.1 ± 35.8 234.0 ± 53.9 0.088 249.1 ± 59.8 314.1 ± 69.4 0.012
Fluorescent AGEs (a.u.) 57.8 ± 20.3 72.3 ± 25.2 0.018 67.3 ± 18.9 79.6 ± 26.7 0.107
sRAGE (ng/mL) 934.9 ± 778.5 1614.7 ±1068.5 0.011 1081.7 ± 885.5 1897.8 ±1192.4 0.022
Left atrial area (cm 2 ) 21.9 ± 5.3 28.3 ± 7.3 0.001 25.2 ± 6.9 30.1 ± 6.3 0.037
Left atrial volume (cm 3 ) 52.0 ± 14.9 65.4 ± 8.4 0.001 56.2 ± 11.4 65.3 ± 8.8 0.017
LVEF < 50 % 85.3 60.0 0.036 65.4 61.5 0.813
ACEI/ARB 97.1 79.2 0.036 96.0 92.3 0.573
Statins
Abbreviations as inTable 1.
37.1 37.5 0.978 72.0 38.5 0.045
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