INTRODUCCIÓN: REVISIÓN CRITICA DEL PROBLEMA

CAPÍTULO IV
During the follow-up period, 11 patients died and 18 were hospitalized because of
worsening CHF. Plasma levels of fluorescent AGE and sRAGE were higher in non
survivors compared to survivors and in the group with cardiac events compared to
the group without cardiac events (Table 1).
High levels of plasma sRAGE but not of fluorescent AGE (defined as higher than
the median) were associated with a higher rate of mortality and rehospitalization
because of worsening CHF in patients with stable CHF (Table 2). By univariate
analysis, hemoglobin, high-density lipoprotein cholesterol, NT–pro-BNP, and
sRAGE were significant predictors of mortality. Backward stepwise multivariate
analysis showed that SHFS, NT–pro-BNP, and sRAGE were significant
independent predictors for mortality (Figure 2). Model discrimination was assessed
by a receiver operator characteristic curve and he c statistic was 0.88 (0.79 to
0.96). In relation to cardiac events in aggregate, in univariate analysis the same
variables as for mortality plus age (per decade), severe CHF, ischemic cause,
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