INTRODUCCIÓN: REVISIÓN CRITICA DEL PROBLEMA

RESULTADOS
A significant direct correlation existed between plasma levels of sRAGE and
SHFS, as shown in Figure 1. Adjusted curves of mortality and cardiac event rate
by multivariable Cox analysis showed that high levels of sRAGE were a good
predictor of mortality and worsening of CHF independently of SHFS, kidney
function, and levels of NT–pro-BNP (Figure 4).
Discussion
Our study demonstrates for the first time that sRAGE is a highly sensitive and
specific marker that provides additional prognostic information independently of
multimarker SHFS and other known prognostic parameters such as BNP and
creatinine in the currently treated CHF population. Moreover, we confirmed a
previously reported association of sRAGE with worse survival and higher
hospitalization rate in CHF.
The SHFS is the first and currently the best-validated multimarker risk assessment
tool developed to predict outcomes in patients with HF, which incorporates not
only clinical but also treatment variables 267 . However, this score presents some
limitations, namely its limited generalization to the entire CHF population, because
99