thesis

246
A
B
Neuron
resistance (MΩ)
Electrode
resistance (MΩ)
C
20 mV
20 mV
20 mV
600
0
100
100 ms
0
0 Time (s)
590
100 ms
1
20 mV
1
20 mV
100 ms
100 ms
2
2
2
without model update
Figure 9.4 – Test of the compensation method on real data. A. A fluctuating current
(current B) is injected into a neuron of the mouse auditory cortex during a patch clamp experiment.
Top : raw recorded trace. Bottom : compensated trace. B. A 590s long fluctuating
current (current A, mean 10 pA, standard deviation 30 pA) is injected into a neuron. The trace is
divided in 1 s windows, and the fitting procedure is applied independently on each window. Top :
estimated neuron resistance as a function of time. Bottom : estimated electrode resistance as a
function of time. Recordings at times 1 and 2 are shown in C. C. Raw (gray) and compensated
(black) traces at times 1 (left, Re = 33 MΩ) and 2 (top right, Re = 81 MΩ). Bottom right : same
as above but using the electrode resistance obtained at time 1 (Re = 33 MΩ).