View/Open - DSpace@Unipr

More documents

Recommendations

Info

methodological recommendations and unresolved questions. Eur Respir J 2005; 26:523–548 15 Apostoli P, Morandi C, Menditto A. Multiple determination of elements in human seminal plasma. J Trace Elem Med Biol 1998; 11:182–184 16 Apostoli P. Elements in environmental and occupational medicine. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 778:63–97 17 Bernard A, Roels H, Buchet JP, et al. Decrease of serum Clara cell protein in smokers [letter]. Lancet 1992; 339:1620 18 Hermans C, Aly O, Nyberg BI, et al. Determinants of Clara cell protein (CC16) concentration in serum: a reassessment with two different immunoassays. Clin Chim Acta 1998; 272:101–110 19 Doyle IR, Hermans C, Bernard A, et al. Clearance of Clara cell secretory protein 16 (CC16) and surfactant proteins A and B from blood in acute respiratory failure. Am J Respir Crit Care Med 1998; 158:1528–1535 20 Nagae H, Takahashi H, Kuroki Y, et al. Enzyme-linked immunosorbent assay using F(ab) 2 fragment for the detection of human pulmonary surfactant protein D in sera. Clin Chim Acta 1997; 266:157–171 21 Maier EA, Rastegar F, Heimburger R, et al. Simultaneous determination of trace elements in lavage fluids from human bronchial alveoli by energy dispersive x-ray fluorescence: 1. Technique and determination of the normal reference interval. Clin Chem 1985; 31:551–555 22 Romeo L, Maranelli G, Malesani F, et al. Tentative reference values for some elements in broncho-alveolar lavage fluid. Sci Total Environ 1992; 120:103–110 23 Karadag F, Cildag O, Altinisik M, et al. Trace elements as a component of oxidative stress in COPD. Respirology 2004; 9:33–37 24 Chiba M, Masironi R. Toxic and trace elements in tobacco and tobacco smoke. Bull World Health Org 1992; 70:269–275 25 Rustemeier K, Stabbert R, Haussmann HJ, et al. Evaluation of the potential effects of ingredients added to cigarettes: Part 2. Chemical composition of mainstream smoke. Food Chem Toxicol 2002; 40:93–104 26 Hendrick DJ. Smoking, cadmium, and emphysema. Thorax 2004; 59:184–185 27 Tatrai E, Kovacikova Z, Hudak A, et al. Comparative in vitro toxicity of cadmium and lead on redox cycling in type II pneumocytes. J Appl Toxicol 2001; 21:479–483 28 Mannino DM, Holguin F, Greves HM, et al. Urinary cadmium levels predict lower lung function in current and former smokers: data from the Third National Health and Nutrition Examination Survey. Thorax 2004; 59:194–198 29 MacNee W, Donaldson K. Mechanism of lung injury caused by PM 10 and ultrafine particles with special reference to COPD. Eur Respir J 2003; 21:47–51 30 Pope CA, Dockery DW. Epidemiology of particle effects. In: Holgate ST, Samet JM, Koren HS, et al, eds. Air pollution and health. San Diego, CA: Academic Press, 1999; 673–705 31 Bachelet M, Pinot F, Polla RI, et al. Toxicity of cadmium in tobacco smoke: protection by antioxidants and chelating resins. Free Radic Res 2002; 36:99–106 32 Kubala-Kukus A, Braziewicz J, Banas D, et al. Trace element load in cancer and normal lung tissue. Nucl Instrum Methods Phys Res Sect B 1999; 150:193–199 33 Jiang F, Guo Y, Salvemini D, et al. Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. Br J Pharmacol 2003; 139:1127– 1134 34 Effros RM, Peterson B, Casaburi R, et al. Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects. J Appl Physiol 2005; 99:1286– 1292 35 Hermans C, Bernard A. Lung epithelium-specific proteins: characteristics and potential applications as markers. Am J Respir Crit Care Med 199; 159:646–678 36 Hermans C, Dong P, Robin M, et al. Determinants of serum levels of surfactant proteins A and B and Clara cell protein CC16. Biomarkers 2003; 8:461–471 37 Leth-Larsen R, Floridon C, Nielsen O, et al. Surfactant protein D in the female genital tract. Mol Hum Reprod 2004; 10:149–154 www.chestjournal.org CHEST / 129 /5/MAY, 2006 1297 Downloaded from chestjournals.org on May 23, 2007 Copyright © 2006 by American College of Chest Physicians
Exhaled Metallic Elements and Serum Pneumoproteins in Asymptomatic Smokers and Patients With COPD or Asthma Antonio Mutti, Massimo Corradi, Matteo Goldoni, Maria Vittoria Vettori, Alfred Bernard and Pietro Apostoli Chest 2006;129;1288-1297 DOI 10.1378/chest.129.5.1288 Updated Information & Services References Permissions & Licensing Reprints Email alerting service This information is current as of May 23, 2007 Images in PowerPoint format Updated information and services, including high-resolution figures, can be found at: http://chestjournals.org/cgi/content/full/129/5/1288 This article cites 35 articles, 14 of which you can access for free at: http://chestjournals.org/cgi/content/full/129/5/1288#BIBL Information about reproducing this article in parts (figures, tables) or in its entirety can be found online at: http://chestjournals.org/misc/reprints.shtml Information about ordering reprints can be found online: http://chestjournals.org/misc/reprints.shtml Receive free email alerts when new articles cite this article sign up in the box at the top right corner of the online article. Figures that appear in CHEST articles can be downloaded for teaching purposes in PowerPoint slide format. See any online article figure for directions. Downloaded from chestjournals.org on May 23, 2007 Copyright © 2006 by American College of Chest Physicians
Page 1 and 2:
UNIVERSITÀ DEGLI STUDI DI PARMA DO
Page 3 and 4:
Riassunto La raccolta e l’analisi
Page 5 and 6:
Sommario CAPITOLO 1: Introduzione .
Page 7 and 8:
5.3.1 Scopi dello studio ..........
Page 9 and 10:
Congressi Nazionali ed Internaziona
Page 11 and 12:
ischio consiste nel caratterizzare
Page 13 and 14:
1.1 I biomarcatori Il termine “bi
Page 15 and 16:
Forschungsgemainschaft (DFG, 2004).
Page 17 and 18:
elettrotermico (ETAAS) fino ad arri
Page 19 and 20:
E’ possibile studiare la cinetica
Page 21 and 22:
Tra le molecole dosate con maggior
Page 23 and 24:
circostanze, sarebbe più appropria
Page 25 and 26:
3.3.2 Miscele di inquinanti comples
Page 27 and 28:
3.3.3.3 Elementi metallici nel BAL
Page 29 and 30:
- Cromatura galvanica, che prevede
Page 31 and 32:
Molti studi in vivo e in vitro hann
Page 33 and 34:
tra tessuto sano e malato (Raithel
Page 35 and 36:
4.3.2 Cd e il fumo di sigaretta Le
Page 37 and 38:
sulla sintesi dell’eme. I valori
Page 39 and 40:
- Smontaggio, pulitura e deposito n
Page 41 and 42:
5.2.2.3 Le misure ambientali Le mis
Page 43 and 44:
5.2.3 Risultati I livelli di Cr mis
Page 45 and 46:
di DPC in 1-butanolo e 100 μl di H
Page 47 and 48:
5.4 Un terzo studio confermativo ne
Page 49 and 50:
5.5 Cr nel tessuto polmonare e nel
Page 51 and 52:
I livelli di Cromo erano 0.14 (0.04
Page 53 and 54:
- Monitoraggio ambientale: è stato
Page 55 and 56:
6.2 Nichel, Cadmio e Piombo esalati
Page 57 and 58:
CAPITOLO 5: Discussione 7. Esposizi
Page 59 and 60:
Cr(VI) nel CAE rinforza l’ipotesi
Page 61 and 62:
Se nell’urina viene escreta una m
Page 63 and 64:
sigaretta (Rustemeier et al., 2002;
Page 65 and 66:
Cr(VI) nell’indurre risposte corr
Page 67 and 68:
sul passaggio di Cr nei due stati d
Page 69 and 70:
depositarsi ad alte concentrazioni
Page 71 and 72:
Poiché il volume esalato non è al
Page 73 and 74:
11.8 Conclusioni Il sistema appare
Page 75 and 76:
Amorim, L.C., de Cardeal, L.Z., 200
Page 77 and 78:
Bernard, A., 2004. Renal dysfunctio
Page 79 and 80:
Coogan, T.P., Squibb, K.S., Motz, J
Page 81 and 82:
Effros, R.M., Hoagland, K.W., Bosbo
Page 83 and 84:
Hazelwood, K.J., Drake, P.L., Ashle
Page 85 and 86:
Microscopic analysis of chromium ac
Page 87 and 88:
McGarvey, L.P., Dunbar, K., Martin,
Page 89 and 90:
NIOSH, 2003. NIOSH Method 7703: Hex
Page 91 and 92:
Rahman, I., Kelly, F., 2003. Biomar
Page 93 and 94:
Tatrai, E., Kovacikova, Z., Hudak,
Page 95 and 96:
13. Tabelle 86
Page 97 and 98:
Controlli Lavoratori N° soggetti 2
Page 99 and 100:
N° soggetti 10 Sesso (M/F) 10/0 La
Page 101 and 102:
Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
Page 103 and 104:
Controlli NSCLC tempo 1 NSCLC tempo
Page 105 and 106:
Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
Page 107 and 108:
Composizione SERETIDE® 0.3-0.5 mic
Page 109 and 110:
Figura 1: Tavola periodica degli el
Page 111 and 112:
Figura 3. Meccanismi di tossicità
Page 113 and 114:
Figura 5. (A) Cromatura Galvanica -
Page 115 and 116:
Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
Page 117 and 118:
mAbs a 540/545 nm : r = 0.9999, int
Page 119 and 120:
A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
Page 121 and 122:
Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
Page 123 and 124:
1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
Page 125 and 126:
Cr Tessuto (μg/g tessuto secco) 1
Page 127 and 128:
Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
Page 129 and 130:
Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
Page 131 and 132:
Figura 23: Modello teorico che desc
Page 133 and 134:
Figura 25: deposizione polmonare ne
Page 135 and 136: Figura 27: distribuzione delle part
Page 137 and 138: Figura 29: andamento della concentr
Page 139 and 140: Figura 31: il segnale così come mi
Page 141 and 142: Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
Page 143 and 144: Particelle 1.0 micron (Part/L) 1400
Page 145 and 146: Pubblicazioni scientifiche nazional
Page 147 and 148: Altre attività e pubblicazioni, An
Page 149 and 150: Eurotox 2006 - 43 rd congress of th
Page 151 and 152: • Goldoni Matteo, Caglieri A, Pol
Page 153 and 154: Allegato I I
Page 155 and 156: Materials and Methods Subjects. Tab
Page 157 and 158: 280 μL at T 2) and controls (1,585
Page 159 and 160: Allegato II II
Page 161 and 162: 230 M. Goldoni et al. / Analytica C
Page 167 and 168: Allegato III III
Page 169 and 170: 488 Int Arch Occup Environ Health (
Page 175 and 176: Allegato IV IV
Page 177 and 178: CHEST Original Research Exhaled Met
Page 179 and 180: Subject Characteristics Materials a
Page 181 and 182: Figure 1. Lead, cadmium, aluminum (
Page 183 and 184: Figure 3. Iron (expressed in log 10
Page 185: dedicated to elemental analysis, an
show all

View/Open - DSpace@Unipr

Create successful ePaper yourself

Delete template?

Save as template?