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ATSDR, 2005. Toxicological Profile for Nickel. Agency for toxic substances and disease registry, Atlanta, USA, pp. 397. ATSDR, 2007. Toxicological Profile for Lead. Agency for Toxic Substances and Disease Registry, Atlanta, USA, pp. 632. Bagchi, D., Stohs, S.J., Downs, B.W., Bagchi, M., Preuss, H.G., 2002. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 180, 5-22. Balint, B., Donnelly, L.E., Hanazawa, T., Kharitonov, S.A., Barnes, P.J., 2001. Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke. Thorax 56, 456-461. Barr, D.B., Wilder, L.C., Caudill, S.P., Gonzalez, A.J., Needham, L.L., Pirkle, J.L., 2005. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 113, 192-200. Barregard, L., Sallsten, G., Andersson, L., Almstrand, A.C., Gustafson, P., Andersson, M., Olin, A.C., 2007. Experimental exposure to wood smoke: Effects on airway inflammation and oxidative stress. Occup Environ Med. Barreto, M., Villa, M.P., Corradi, M., Barberi, S., Monaco, G., Martella, S., Bohmerova, Z., Sabatino, G., Ronchetti, R., 2006. Non-invasive assessment of airway inflammation in ship-engine workers. Int J Immunopathol Pharmacol 19, 601-608. Baumgardt, B., Jackwerth, E., Otto, H., Tolg, G., 1986. Trace analysis to determine heavy metal load in lung tissue. A contribution to substantiation of occupational hazards. Int Arch Occup Environ Health 58, 27-34. Bener, A., Almehdi, A.M., Alwash, R., Al-Neamy, F.R., 2001. A pilot survey of blood lead levels in various types of workers in the United Arab Emirates. Environ Int 27, 311-314. 67
Bernard, A., 2004. Renal dysfunction induced by cadmium: biomarkers of critical effects. Biometals 17, 519-523. Birk, T., Mundt, K.A., Dell, L.D., Luippold, R.S., Miksche, L., Steinmann-Steiner- Haldenstaett, W., Mundt, D.J., 2006. Lung cancer mortality in the German chromate industry, 1958 to 1998. J Occup Environ Med 48, 426-433. Bloemen, K., Lissens, G., Desager, K., Schoeters, G., 2007. Determinants of variability of protein content, volume and pH of exhaled breath condensate. Respir Med 101, 1331-1337. Bonetto, G., Corradi, M., Carraro, S., Zanconato, S., Alinovi, R., Folesani, G., Da Dalt, L., Mutti, A., Baraldi, E., 2006. Longitudinal monitoring of lung injury in children after acute chlorine exposure in a swimming pool. Am J Respir Crit Care Med 174, 545-549. Borai, E.H., El-Sofany, E.A., Abdel-Halim, A.S., Soliman, A.A., 2002. Speciation of hexavalent chromium in atmospheric particulate samples by selective extraction and ion chromatographic determination. TrAC Trends in Analytical Chemistry 21, 741-745. Boyce, P.D., Kim, J.Y., Weissman, D.N., Hunt, J., Christiani, D.C., 2006. pH increase observed in exhaled breath condensate from welding fume exposure. J Occup Environ Med 48, 353-356. Bradshaw, L.M., Fishwick, D., Slater, T., Pearce, N., 1998. Chronic bronchitis, work related respiratory symptoms, and pulmonary function in welders in New Zealand. Occup Environ Med 55, 150-154. Brera, S., Nicolini, A., 2005. Respiratory manifestations due to nickel. Acta Otorhinolaryngol Ital 25, 113-115. Brooks, W.M., Lash, H., Kettle, A.J., Epton, M.J., 2006. Optimising hydrogen peroxide measurement in exhaled breath condensate. Redox Rep 11, 78-84. 68
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UNIVERSITÀ DEGLI STUDI DI PARMA DO
Page 3 and 4:
Riassunto La raccolta e l’analisi
Page 5 and 6:
Sommario CAPITOLO 1: Introduzione .
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5.3.1 Scopi dello studio ..........
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Congressi Nazionali ed Internaziona
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ischio consiste nel caratterizzare
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1.1 I biomarcatori Il termine “bi
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Forschungsgemainschaft (DFG, 2004).
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elettrotermico (ETAAS) fino ad arri
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E’ possibile studiare la cinetica
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Tra le molecole dosate con maggior
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circostanze, sarebbe più appropria
Page 25 and 26: 3.3.2 Miscele di inquinanti comples
Page 27 and 28: 3.3.3.3 Elementi metallici nel BAL
Page 29 and 30: - Cromatura galvanica, che prevede
Page 31 and 32: Molti studi in vivo e in vitro hann
Page 33 and 34: tra tessuto sano e malato (Raithel
Page 35 and 36: 4.3.2 Cd e il fumo di sigaretta Le
Page 37 and 38: sulla sintesi dell’eme. I valori
Page 39 and 40: - Smontaggio, pulitura e deposito n
Page 41 and 42: 5.2.2.3 Le misure ambientali Le mis
Page 43 and 44: 5.2.3 Risultati I livelli di Cr mis
Page 45 and 46: di DPC in 1-butanolo e 100 μl di H
Page 47 and 48: 5.4 Un terzo studio confermativo ne
Page 49 and 50: 5.5 Cr nel tessuto polmonare e nel
Page 51 and 52: I livelli di Cromo erano 0.14 (0.04
Page 53 and 54: - Monitoraggio ambientale: è stato
Page 55 and 56: 6.2 Nichel, Cadmio e Piombo esalati
Page 57 and 58: CAPITOLO 5: Discussione 7. Esposizi
Page 59 and 60: Cr(VI) nel CAE rinforza l’ipotesi
Page 61 and 62: Se nell’urina viene escreta una m
Page 63 and 64: sigaretta (Rustemeier et al., 2002;
Page 65 and 66: Cr(VI) nell’indurre risposte corr
Page 67 and 68: sul passaggio di Cr nei due stati d
Page 69 and 70: depositarsi ad alte concentrazioni
Page 71 and 72: Poiché il volume esalato non è al
Page 73 and 74: 11.8 Conclusioni Il sistema appare
Page 75: Amorim, L.C., de Cardeal, L.Z., 200
Page 79 and 80: Coogan, T.P., Squibb, K.S., Motz, J
Page 81 and 82: Effros, R.M., Hoagland, K.W., Bosbo
Page 83 and 84: Hazelwood, K.J., Drake, P.L., Ashle
Page 85 and 86: Microscopic analysis of chromium ac
Page 87 and 88: McGarvey, L.P., Dunbar, K., Martin,
Page 89 and 90: NIOSH, 2003. NIOSH Method 7703: Hex
Page 91 and 92: Rahman, I., Kelly, F., 2003. Biomar
Page 93 and 94: Tatrai, E., Kovacikova, Z., Hudak,
Page 95 and 96: 13. Tabelle 86
Page 97 and 98: Controlli Lavoratori N° soggetti 2
Page 99 and 100: N° soggetti 10 Sesso (M/F) 10/0 La
Page 101 and 102: Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
Page 103 and 104: Controlli NSCLC tempo 1 NSCLC tempo
Page 105 and 106: Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
Page 107 and 108: Composizione SERETIDE® 0.3-0.5 mic
Page 109 and 110: Figura 1: Tavola periodica degli el
Page 111 and 112: Figura 3. Meccanismi di tossicità
Page 113 and 114: Figura 5. (A) Cromatura Galvanica -
Page 115 and 116: Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
Page 117 and 118: mAbs a 540/545 nm : r = 0.9999, int
Page 119 and 120: A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
Page 121 and 122: Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
Page 123 and 124: 1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
Page 125 and 126: Cr Tessuto (μg/g tessuto secco) 1
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Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
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Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
Page 131 and 132:
Figura 23: Modello teorico che desc
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Figura 25: deposizione polmonare ne
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Figura 27: distribuzione delle part
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Figura 29: andamento della concentr
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Figura 31: il segnale così come mi
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Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
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Particelle 1.0 micron (Part/L) 1400
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Pubblicazioni scientifiche nazional
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Altre attività e pubblicazioni, An
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Eurotox 2006 - 43 rd congress of th
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• Goldoni Matteo, Caglieri A, Pol
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Allegato I I
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Materials and Methods Subjects. Tab
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280 μL at T 2) and controls (1,585
Page 159 and 160:
Allegato II II
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230 M. Goldoni et al. / Analytica C
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Page 165 and 166:
Page 167 and 168:
Allegato III III
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488 Int Arch Occup Environ Health (
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Allegato IV IV
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CHEST Original Research Exhaled Met
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Subject Characteristics Materials a
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Figure 1. Lead, cadmium, aluminum (
Page 183 and 184:
Figure 3. Iron (expressed in log 10
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dedicated to elemental analysis, an
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Exhaled Metallic Elements and Serum
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