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DFG, 2004. List of MAK and BAT values. Wiley -VCH Verlag, Weinheim, Germany. Doll, R., 1990. Reports of the international committee on Nickel carcinogenesis in man. Scand J Work Environ Health 16, 9-82. Donaldson, K., MacNee, W., 2001. Potential mechanisms of adverse pulmonary and cardiovascular effects of particulate air pollution (PM10). Int J Hyg Environ Health 203, 411-415. Doniec, Z., Nowak, D., Tomalak, W., Pisiewicz, K., Kurzawa, R., 2005. Passive smoking does not increase hydrogen peroxide (H2O2) levels in exhaled breath condensate in 9-year-old healthy children. Pediatr Pulmonol 39, 41-45. Drake II, E.N., Sky-Peck, H.H., 1989. Discriminant analysis of trace element distribution in normal and malignant human tissues. Cancer Res 49, 4210-4215. Dwyer, T.M., 2004. Sampling airway surface liquid: non-volatiles in the exhaled breath condensate. Lung 182, 241-250. Edelman, D.A., Roggli, V.L., 1989. The accumulation of nickel in human lungs. Environ Health Perspect 81, 221-224. Edwards, D.A., Man, J.C., Brand, P., Katstra, J.P., Sommerer, K., Stone, H.A., Nardell, E., Scheuch, G., 2004. Inhaling to mitigate exhaled bioaerosols. Proc Natl Acad Sci U S A 101, 17383-17388. Effros, R.M., Biller, J., Foss, B., Hoagland, K., Dunning, M.B., Castillo, D., Bosbous, M., Sun, F., Shaker, R., 2003. A simple method for estimating respiratory solute dilution in exhaled breath condensates. Am J Respir Crit Care Med 168, 1500-1505. Effros, R.M., Dunning, M.B., 3rd, Biller, J., Shaker, R., 2004. The promise and perils of exhaled breath condensates. Am J Physiol Lung Cell Mol Physiol 287, L1073-1080. 71
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UNIVERSITÀ DEGLI STUDI DI PARMA DO
Page 3 and 4:
Riassunto La raccolta e l’analisi
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Sommario CAPITOLO 1: Introduzione .
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5.3.1 Scopi dello studio ..........
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Congressi Nazionali ed Internaziona
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ischio consiste nel caratterizzare
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1.1 I biomarcatori Il termine “bi
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Forschungsgemainschaft (DFG, 2004).
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elettrotermico (ETAAS) fino ad arri
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E’ possibile studiare la cinetica
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Tra le molecole dosate con maggior
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circostanze, sarebbe più appropria
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3.3.2 Miscele di inquinanti comples
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3.3.3.3 Elementi metallici nel BAL
Page 29 and 30: - Cromatura galvanica, che prevede
Page 31 and 32: Molti studi in vivo e in vitro hann
Page 33 and 34: tra tessuto sano e malato (Raithel
Page 35 and 36: 4.3.2 Cd e il fumo di sigaretta Le
Page 37 and 38: sulla sintesi dell’eme. I valori
Page 39 and 40: - Smontaggio, pulitura e deposito n
Page 41 and 42: 5.2.2.3 Le misure ambientali Le mis
Page 43 and 44: 5.2.3 Risultati I livelli di Cr mis
Page 45 and 46: di DPC in 1-butanolo e 100 μl di H
Page 47 and 48: 5.4 Un terzo studio confermativo ne
Page 49 and 50: 5.5 Cr nel tessuto polmonare e nel
Page 51 and 52: I livelli di Cromo erano 0.14 (0.04
Page 53 and 54: - Monitoraggio ambientale: è stato
Page 55 and 56: 6.2 Nichel, Cadmio e Piombo esalati
Page 57 and 58: CAPITOLO 5: Discussione 7. Esposizi
Page 59 and 60: Cr(VI) nel CAE rinforza l’ipotesi
Page 61 and 62: Se nell’urina viene escreta una m
Page 63 and 64: sigaretta (Rustemeier et al., 2002;
Page 65 and 66: Cr(VI) nell’indurre risposte corr
Page 67 and 68: sul passaggio di Cr nei due stati d
Page 69 and 70: depositarsi ad alte concentrazioni
Page 71 and 72: Poiché il volume esalato non è al
Page 73 and 74: 11.8 Conclusioni Il sistema appare
Page 75 and 76: Amorim, L.C., de Cardeal, L.Z., 200
Page 77 and 78: Bernard, A., 2004. Renal dysfunctio
Page 79: Coogan, T.P., Squibb, K.S., Motz, J
Page 83 and 84: Hazelwood, K.J., Drake, P.L., Ashle
Page 85 and 86: Microscopic analysis of chromium ac
Page 87 and 88: McGarvey, L.P., Dunbar, K., Martin,
Page 89 and 90: NIOSH, 2003. NIOSH Method 7703: Hex
Page 91 and 92: Rahman, I., Kelly, F., 2003. Biomar
Page 93 and 94: Tatrai, E., Kovacikova, Z., Hudak,
Page 95 and 96: 13. Tabelle 86
Page 97 and 98: Controlli Lavoratori N° soggetti 2
Page 99 and 100: N° soggetti 10 Sesso (M/F) 10/0 La
Page 101 and 102: Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
Page 103 and 104: Controlli NSCLC tempo 1 NSCLC tempo
Page 105 and 106: Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
Page 107 and 108: Composizione SERETIDE® 0.3-0.5 mic
Page 109 and 110: Figura 1: Tavola periodica degli el
Page 111 and 112: Figura 3. Meccanismi di tossicità
Page 113 and 114: Figura 5. (A) Cromatura Galvanica -
Page 115 and 116: Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
Page 117 and 118: mAbs a 540/545 nm : r = 0.9999, int
Page 119 and 120: A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
Page 121 and 122: Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
Page 123 and 124: 1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
Page 125 and 126: Cr Tessuto (μg/g tessuto secco) 1
Page 127 and 128: Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
Page 129 and 130: Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
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Figura 23: Modello teorico che desc
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Figura 25: deposizione polmonare ne
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Figura 27: distribuzione delle part
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Figura 29: andamento della concentr
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Figura 31: il segnale così come mi
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Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
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Particelle 1.0 micron (Part/L) 1400
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Pubblicazioni scientifiche nazional
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Altre attività e pubblicazioni, An
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Eurotox 2006 - 43 rd congress of th
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• Goldoni Matteo, Caglieri A, Pol
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Allegato I I
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Materials and Methods Subjects. Tab
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280 μL at T 2) and controls (1,585
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Allegato II II
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230 M. Goldoni et al. / Analytica C
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Page 165 and 166:
Page 167 and 168:
Allegato III III
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488 Int Arch Occup Environ Health (
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Page 173 and 174:
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Allegato IV IV
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CHEST Original Research Exhaled Met
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Subject Characteristics Materials a
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Figure 1. Lead, cadmium, aluminum (
Page 183 and 184:
Figure 3. Iron (expressed in log 10
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dedicated to elemental analysis, an
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Exhaled Metallic Elements and Serum
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