OSHA, O.S.H.A., 2006b. Small Entity Compliance Guide for the Hexavalent Chromium Standards. OSHA, Washington, USA. Paakko, P., Kokkonen, P., Anttila, S., Kalliomaki, P.L., 1989. Cadmium and chromium as markers of smoking in human lung tissue. Environ Res 49, 197-207. Patrick, L., 2006a. Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern Med Rev 11, 114- 127. Patrick, L., 2006b. Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment. Altern Med Rev 11, 2-22. Paustenbach, D., Galbraith, D., 2006. Biomonitoring and biomarkers: exposure assessment will never be the same. Environ Health Perspect 114, 1143-1149. Periago, J.F., Luna, A., Morente, A., Zambudio, A., 1992. Design and evaluation of an exhaled breath sampler for biological monitoring of organic solvents. J Appl Toxicol 12, 91-96. Poli, D., Carbognani, P., Corradi, M., Goldoni, M., Acampa, O., Balbi, B., Bianchi, L., Rusca, M., Mutti, A., 2005. Exhaled volatile organic compounds in patients with nonsmall cell lung cancer: cross sectional and nested short-term follow-up study. Respir Res 6, 71. Prado, C., Tortosa, J.A., Ibarra, I., Luna, A., Periago, J.F., 1997. Biological monitoring of occupational exposure to isoflurane by measurement of isoflurane exhaled breath. J Appl Toxicol 17, 179-183. Prieto, L., Ferrer, A., Palop, J., Domenech, J., Llusar, R., Rojas, R., 2007. Differences in exhaled breath condensate pH measurements between samples obtained with two commercial devices. Respir Med 101, 1715-1720. 81
Rahman, I., Kelly, F., 2003. Biomarkers in breath condensate: a promising new non- invasive technique in free radical research. Free Radic Res 37, 1253-1266. Raithel, H.J., Ebner, G., Schaller, K.H., Schellmann, B., Valentin, H., 1987. Problems in establishing norm values for nickel and chromium concentrations in human pulmonary tissue. Am J Ind Med 12, 55-70. Raithel, H.J., Hennig, F., Schaller, K.H., 1989a. Quantitative determination of chromium and nickel in tumour and tumour-free human tissue. J Environ Pathol Toxicol Oncol 9, 115-126. Raithel, H.J., Schaller, K.H., Akslen, L.A., Myking, A.O., Morkve, O., Gulsvik, A., 1989b. Analyses of chromium and nickel in human pulmonary tissue. Investigations in lung cancer patients and a control population under special consideration of medical expertise aspects. Int Arch Occup Environ Health 61, 507-512. Raithel, H.J., Schaller, K.H., Kraus, T., Lehnert, G., 1993. Biomonitoring of nickel and chromium in human pulmonary tissue. Int Arch Occup Environ Health 65, S197-200. Romeo, L., Maranelli, G., Malesani, F., Tommasi, I., Cazzadori, A., Graziani, M.S., 1992. Tentative reference values for some elements in broncho-alveolar lavage fluid. The Science of The Total Environment 120, 103-110. Rosias, P.P., Robroeks, C.M., Niemarkt, H.J., Kester, A.D., Vernooy, J.H., Suykerbuyk, J., Teunissen, J., Heynens, J., Hendriks, H.J., Jobsis, Q., Dompeling, E., 2006. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate. Eur Respir J 28, 1036-1041. Rustemeier, K., Stabbert, R., Haussmann, H.J., Roemer, E., Carmines, E.L., 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food and Chemical Toxicology 40, 93-104. Rysz, J., Stolarek, R.A., Luczynski, R., Sarniak, A., Wlodarczyk, A., Kasielski, M., Nowak, D., 2007. Increased hydrogen peroxide concentration in the exhaled breath 82
- Page 1 and 2:
UNIVERSITÀ DEGLI STUDI DI PARMA DO
- Page 3 and 4:
Riassunto La raccolta e l’analisi
- Page 5 and 6:
Sommario CAPITOLO 1: Introduzione .
- Page 7 and 8:
5.3.1 Scopi dello studio ..........
- Page 9 and 10:
Congressi Nazionali ed Internaziona
- Page 11 and 12:
ischio consiste nel caratterizzare
- Page 13 and 14:
1.1 I biomarcatori Il termine “bi
- Page 15 and 16:
Forschungsgemainschaft (DFG, 2004).
- Page 17 and 18:
elettrotermico (ETAAS) fino ad arri
- Page 19 and 20:
E’ possibile studiare la cinetica
- Page 21 and 22:
Tra le molecole dosate con maggior
- Page 23 and 24:
circostanze, sarebbe più appropria
- Page 25 and 26:
3.3.2 Miscele di inquinanti comples
- Page 27 and 28:
3.3.3.3 Elementi metallici nel BAL
- Page 29 and 30:
- Cromatura galvanica, che prevede
- Page 31 and 32:
Molti studi in vivo e in vitro hann
- Page 33 and 34:
tra tessuto sano e malato (Raithel
- Page 35 and 36:
4.3.2 Cd e il fumo di sigaretta Le
- Page 37 and 38:
sulla sintesi dell’eme. I valori
- Page 39 and 40: - Smontaggio, pulitura e deposito n
- Page 41 and 42: 5.2.2.3 Le misure ambientali Le mis
- Page 43 and 44: 5.2.3 Risultati I livelli di Cr mis
- Page 45 and 46: di DPC in 1-butanolo e 100 μl di H
- Page 47 and 48: 5.4 Un terzo studio confermativo ne
- Page 49 and 50: 5.5 Cr nel tessuto polmonare e nel
- Page 51 and 52: I livelli di Cromo erano 0.14 (0.04
- Page 53 and 54: - Monitoraggio ambientale: è stato
- Page 55 and 56: 6.2 Nichel, Cadmio e Piombo esalati
- Page 57 and 58: CAPITOLO 5: Discussione 7. Esposizi
- Page 59 and 60: Cr(VI) nel CAE rinforza l’ipotesi
- Page 61 and 62: Se nell’urina viene escreta una m
- Page 63 and 64: sigaretta (Rustemeier et al., 2002;
- Page 65 and 66: Cr(VI) nell’indurre risposte corr
- Page 67 and 68: sul passaggio di Cr nei due stati d
- Page 69 and 70: depositarsi ad alte concentrazioni
- Page 71 and 72: Poiché il volume esalato non è al
- Page 73 and 74: 11.8 Conclusioni Il sistema appare
- Page 75 and 76: Amorim, L.C., de Cardeal, L.Z., 200
- Page 77 and 78: Bernard, A., 2004. Renal dysfunctio
- Page 79 and 80: Coogan, T.P., Squibb, K.S., Motz, J
- Page 81 and 82: Effros, R.M., Hoagland, K.W., Bosbo
- Page 83 and 84: Hazelwood, K.J., Drake, P.L., Ashle
- Page 85 and 86: Microscopic analysis of chromium ac
- Page 87 and 88: McGarvey, L.P., Dunbar, K., Martin,
- Page 89: NIOSH, 2003. NIOSH Method 7703: Hex
- Page 93 and 94: Tatrai, E., Kovacikova, Z., Hudak,
- Page 95 and 96: 13. Tabelle 86
- Page 97 and 98: Controlli Lavoratori N° soggetti 2
- Page 99 and 100: N° soggetti 10 Sesso (M/F) 10/0 La
- Page 101 and 102: Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
- Page 103 and 104: Controlli NSCLC tempo 1 NSCLC tempo
- Page 105 and 106: Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
- Page 107 and 108: Composizione SERETIDE® 0.3-0.5 mic
- Page 109 and 110: Figura 1: Tavola periodica degli el
- Page 111 and 112: Figura 3. Meccanismi di tossicità
- Page 113 and 114: Figura 5. (A) Cromatura Galvanica -
- Page 115 and 116: Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
- Page 117 and 118: mAbs a 540/545 nm : r = 0.9999, int
- Page 119 and 120: A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
- Page 121 and 122: Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
- Page 123 and 124: 1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
- Page 125 and 126: Cr Tessuto (μg/g tessuto secco) 1
- Page 127 and 128: Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
- Page 129 and 130: Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
- Page 131 and 132: Figura 23: Modello teorico che desc
- Page 133 and 134: Figura 25: deposizione polmonare ne
- Page 135 and 136: Figura 27: distribuzione delle part
- Page 137 and 138: Figura 29: andamento della concentr
- Page 139 and 140: Figura 31: il segnale così come mi
- Page 141 and 142:
Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
- Page 143 and 144:
Particelle 1.0 micron (Part/L) 1400
- Page 145 and 146:
Pubblicazioni scientifiche nazional
- Page 147 and 148:
Altre attività e pubblicazioni, An
- Page 149 and 150:
Eurotox 2006 - 43 rd congress of th
- Page 151 and 152:
• Goldoni Matteo, Caglieri A, Pol
- Page 153 and 154:
Allegato I I
- Page 155 and 156:
Materials and Methods Subjects. Tab
- Page 157 and 158:
280 μL at T 2) and controls (1,585
- Page 159 and 160:
Allegato II II
- Page 161 and 162:
230 M. Goldoni et al. / Analytica C
- Page 163 and 164:
232 M. Goldoni et al. / Analytica C
- Page 165 and 166:
234 M. Goldoni et al. / Analytica C
- Page 167 and 168:
Allegato III III
- Page 169 and 170:
488 Int Arch Occup Environ Health (
- Page 171 and 172:
490 Int Arch Occup Environ Health (
- Page 173 and 174:
492 Int Arch Occup Environ Health (
- Page 175 and 176:
Allegato IV IV
- Page 177 and 178:
CHEST Original Research Exhaled Met
- Page 179 and 180:
Subject Characteristics Materials a
- Page 181 and 182:
Figure 1. Lead, cadmium, aluminum (
- Page 183 and 184:
Figure 3. Iron (expressed in log 10
- Page 185 and 186:
dedicated to elemental analysis, an
- Page 187 and 188:
Exhaled Metallic Elements and Serum