Luippold, R.S., Mundt, K.A., Dell, L.D., Birk, T., 2005. Low-level hexavalent chromium exposure and rate of mortality among US chromate production employees. J Occup Environ Med 47, 381-385. Lundstrom, N.G., Englyst, V., Gerhardsson, L., Jin, T., Nordberg, G., 2006. Lung cancer development in primary smelter workers: a nested case-referent study. J Occup Environ Med 48, 376-380. Lundstrom, N.G., Nordberg, G., Englyst, V., Gerhardsson, L., Hagmar, L., Jin, T., Rylander, L., Wall, 1997. Cumulative lead exposure in relation to mortality and lung cancer morbidity in a cohort of primary smelter workers. Scand J Work Environ Health 23, 24-30. MacNee, W., Donaldson, K., 2000. How can ultrafine particles be responsible for increased mortality? Monaldi Arch Chest Dis 55, 135-139. MacNee, W., Donaldson, K., 2003. Mechanism of lung injury caused by PM10 and ultrafine particles with special reference to COPD. Eur Respir J Suppl 40, 47s-51s. Manini, P., De Palma, G., Mutti, A., 2007. Exposure assessment at the workplace: implications of biological variability. Toxicol Lett 168, 210-218. Maniscalco, M., De Laurentiis, G., Pentella, C., Mormile, M., Sanduzzi, A., Carratu, P., Sofia, M., 2006. Exhaled breath condensate as matrix for toluene detection: a preliminary study. Biomarkers 11, 233-240. Masjedi, M.R., Estineh, N., Bahadori, M., Alavi, M., Sprince, N.L., 1989. Pulmonary complications in lead miners. Chest 96, 18-21. Mason, H.J., Williams, N.R., Morgan, M.G., Stevenson, A.J., Armitage, S., 1998. Influence of biological and analytical variation on urine measurements for monitoring exposure to cadmium. Occup Environ Med 55, 132-137. 77
McGarvey, L.P., Dunbar, K., Martin, S.L., Brown, V., Macmahon, J., Ennis, M., Elborn, J.S., 2002. Cytokine concentrations and neutrophil elastase activity in bronchoalveolar lavage and induced sputum from patients with cystic fibrosis, mild asthma and healthy volunteers. J Cyst Fibros 1, 269-275. Metso, T., Haahtela, T., Seveus, L., 2002. Identification of intracellular markers in induced sputum and bronchoalveolar lavage samples in patients with respiratory disorders and healthy persons. Respir Med 96, 918-926. Minoia, C., Apostoli, P., Maranelli, G., Baldi, C., Pozzoli, L., Capodaglio, E., 1988. Urinary chromium levels in subjects living in two north Italy regions. Sci Total Environ 71, 527-531. Mondino, C., Ciabattoni, G., Koch, P., Pistelli, R., Trove, A., Barnes, P.J., Montuschi, P., 2004. Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol 114, 761-767. Montoya, L.D., Lawrence, J., Murthy, G.G.K., Sarnat, J.A., Godleski, J.J., Koutrakis, P., 2004. Continuous measurements of ambient particle deposition in human subjects. Aerosol Sci Tech 38, 980-990. Montuschi, P., Collins, J.V., Ciabattoni, G., Lazzeri, N., Corradi, M., Kharitonov, S.A., Barnes, P.J., 2000. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 162, 1175-1177. Montuschi, P., Martello, S., Felli, M., Mondino, C., Barnes, P.J., Chiarotti, M., 2005. Liquid chromatography/mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children. Respir Res 6, 119. Montuschi, P., Nightingale, J.A., Kharitonov, S.A., Barnes, P.J., 2002. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic Biol Med 33, 1403-1408. 78
- Page 1 and 2:
UNIVERSITÀ DEGLI STUDI DI PARMA DO
- Page 3 and 4:
Riassunto La raccolta e l’analisi
- Page 5 and 6:
Sommario CAPITOLO 1: Introduzione .
- Page 7 and 8:
5.3.1 Scopi dello studio ..........
- Page 9 and 10:
Congressi Nazionali ed Internaziona
- Page 11 and 12:
ischio consiste nel caratterizzare
- Page 13 and 14:
1.1 I biomarcatori Il termine “bi
- Page 15 and 16:
Forschungsgemainschaft (DFG, 2004).
- Page 17 and 18:
elettrotermico (ETAAS) fino ad arri
- Page 19 and 20:
E’ possibile studiare la cinetica
- Page 21 and 22:
Tra le molecole dosate con maggior
- Page 23 and 24:
circostanze, sarebbe più appropria
- Page 25 and 26:
3.3.2 Miscele di inquinanti comples
- Page 27 and 28:
3.3.3.3 Elementi metallici nel BAL
- Page 29 and 30:
- Cromatura galvanica, che prevede
- Page 31 and 32:
Molti studi in vivo e in vitro hann
- Page 33 and 34:
tra tessuto sano e malato (Raithel
- Page 35 and 36: 4.3.2 Cd e il fumo di sigaretta Le
- Page 37 and 38: sulla sintesi dell’eme. I valori
- Page 39 and 40: - Smontaggio, pulitura e deposito n
- Page 41 and 42: 5.2.2.3 Le misure ambientali Le mis
- Page 43 and 44: 5.2.3 Risultati I livelli di Cr mis
- Page 45 and 46: di DPC in 1-butanolo e 100 μl di H
- Page 47 and 48: 5.4 Un terzo studio confermativo ne
- Page 49 and 50: 5.5 Cr nel tessuto polmonare e nel
- Page 51 and 52: I livelli di Cromo erano 0.14 (0.04
- Page 53 and 54: - Monitoraggio ambientale: è stato
- Page 55 and 56: 6.2 Nichel, Cadmio e Piombo esalati
- Page 57 and 58: CAPITOLO 5: Discussione 7. Esposizi
- Page 59 and 60: Cr(VI) nel CAE rinforza l’ipotesi
- Page 61 and 62: Se nell’urina viene escreta una m
- Page 63 and 64: sigaretta (Rustemeier et al., 2002;
- Page 65 and 66: Cr(VI) nell’indurre risposte corr
- Page 67 and 68: sul passaggio di Cr nei due stati d
- Page 69 and 70: depositarsi ad alte concentrazioni
- Page 71 and 72: Poiché il volume esalato non è al
- Page 73 and 74: 11.8 Conclusioni Il sistema appare
- Page 75 and 76: Amorim, L.C., de Cardeal, L.Z., 200
- Page 77 and 78: Bernard, A., 2004. Renal dysfunctio
- Page 79 and 80: Coogan, T.P., Squibb, K.S., Motz, J
- Page 81 and 82: Effros, R.M., Hoagland, K.W., Bosbo
- Page 83 and 84: Hazelwood, K.J., Drake, P.L., Ashle
- Page 85: Microscopic analysis of chromium ac
- Page 89 and 90: NIOSH, 2003. NIOSH Method 7703: Hex
- Page 91 and 92: Rahman, I., Kelly, F., 2003. Biomar
- Page 93 and 94: Tatrai, E., Kovacikova, Z., Hudak,
- Page 95 and 96: 13. Tabelle 86
- Page 97 and 98: Controlli Lavoratori N° soggetti 2
- Page 99 and 100: N° soggetti 10 Sesso (M/F) 10/0 La
- Page 101 and 102: Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
- Page 103 and 104: Controlli NSCLC tempo 1 NSCLC tempo
- Page 105 and 106: Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
- Page 107 and 108: Composizione SERETIDE® 0.3-0.5 mic
- Page 109 and 110: Figura 1: Tavola periodica degli el
- Page 111 and 112: Figura 3. Meccanismi di tossicità
- Page 113 and 114: Figura 5. (A) Cromatura Galvanica -
- Page 115 and 116: Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
- Page 117 and 118: mAbs a 540/545 nm : r = 0.9999, int
- Page 119 and 120: A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
- Page 121 and 122: Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
- Page 123 and 124: 1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
- Page 125 and 126: Cr Tessuto (μg/g tessuto secco) 1
- Page 127 and 128: Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
- Page 129 and 130: Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
- Page 131 and 132: Figura 23: Modello teorico che desc
- Page 133 and 134: Figura 25: deposizione polmonare ne
- Page 135 and 136: Figura 27: distribuzione delle part
- Page 137 and 138:
Figura 29: andamento della concentr
- Page 139 and 140:
Figura 31: il segnale così come mi
- Page 141 and 142:
Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
- Page 143 and 144:
Particelle 1.0 micron (Part/L) 1400
- Page 145 and 146:
Pubblicazioni scientifiche nazional
- Page 147 and 148:
Altre attività e pubblicazioni, An
- Page 149 and 150:
Eurotox 2006 - 43 rd congress of th
- Page 151 and 152:
• Goldoni Matteo, Caglieri A, Pol
- Page 153 and 154:
Allegato I I
- Page 155 and 156:
Materials and Methods Subjects. Tab
- Page 157 and 158:
280 μL at T 2) and controls (1,585
- Page 159 and 160:
Allegato II II
- Page 161 and 162:
230 M. Goldoni et al. / Analytica C
- Page 163 and 164:
232 M. Goldoni et al. / Analytica C
- Page 165 and 166:
234 M. Goldoni et al. / Analytica C
- Page 167 and 168:
Allegato III III
- Page 169 and 170:
488 Int Arch Occup Environ Health (
- Page 171 and 172:
490 Int Arch Occup Environ Health (
- Page 173 and 174:
492 Int Arch Occup Environ Health (
- Page 175 and 176:
Allegato IV IV
- Page 177 and 178:
CHEST Original Research Exhaled Met
- Page 179 and 180:
Subject Characteristics Materials a
- Page 181 and 182:
Figure 1. Lead, cadmium, aluminum (
- Page 183 and 184:
Figure 3. Iron (expressed in log 10
- Page 185 and 186:
dedicated to elemental analysis, an
- Page 187 and 188:
Exhaled Metallic Elements and Serum