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Gibb, H.J., Lees, P.S., Pinsky, P.F., Rooney, B.C., 2000. Lung cancer among workers in chromium chemical production. Am J Ind Med 38, 115-126. Gidlow, D.A., 2004. Lead toxicity. Occup Med (Lond) 54, 76-81. Goldoni, M., Caglieri, A., Andreoli, R., Poli, D., Manini, P., Vettori, M.V., Corradi, M., Mutti, A., 2005. Influence of condensation temperature on selected exhaled breath parameters. BMC Pulm Med 5, 10. Goldoni, M., Caglieri, A., Corradi, M., Poli, D., Rusca, M., Carbognani, P., Mutti, A., 2008. Chromium in exhaled breath condensate and pulmonary tissue of non-small cell lung cancer patients. Int Arch Occup Environ Health 81, 487-493. Goldoni, M., Caglieri, A., Poli, D., Vettori, M.V., Corradi, M., Apostoli, P., Mutti, A., 2006. Determination of hexavalent chromium in exhaled breath condensate and environmental air among chrome plating workers. Anal Chim Acta 562, 229-235. Goldoni, M., Catalani, S., De Palma, G., Manini, P., Acampa, O., Corradi, M., Bergonzi, R., Apostoli, P., Mutti, A., 2004. Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. Environ Health Perspect 112, 1293-1298. Grimsrud, T.K., Berge, S.R., Haldorsen, T., Andersen, A., 2005. Can Lung Cancer Risk Among Nickel Refinery Workers Be Explained by Occupational Exposures Other Than Nickel? Epidemiology 16, 146-154. Grimsrud, T.K., Berge, S.R., Martinsen, J.I., Andersen, A., 2003. Lung cancer incidence among Norwegian nickel-refinery workers. J Environ Monit 5, 190-197. Grimsrud, T.K., Peto, J., 2006. Persisting risk of nickel related lung cancer and nasal cancer among Clydach refiners. Occup Environ Med 63, 365-366. 73
Hazelwood, K.J., Drake, P.L., Ashley, K., Marcy, D., 2004. Field method for the determination of insoluble or total hexavalent chromium in workplace air. J Occup Environ Hyg 1, 613-619. Hendrick, D.J., 2004. Smoking, Cadmium and emphysema. Thorax 59, 184-185. Heyder, J., 2004. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug delivery. Proc Am Thorac Soc 1, 315-320. Hofmann, W., Morawska, L., Bergmann, R., 2001. Environmental tobacco smoke deposition in the human respiratory tract: differences between experimental and theoretical approaches. J Aerosol Med 14, 317-326. Horvath, I., Hunt, J., Barnes, P.J., Alving, K., Antczak, A., Baraldi, E., Becher, G., van Beurden, W.J., Corradi, M., Dekhuijzen, R., Dweik, R.A., Dwyer, T., Effros, R., Erzurum, S., Gaston, B., Gessner, C., Greening, A., Ho, L.P., Hohlfeld, J., Jobsis, Q., Laskowski, D., Loukides, S., Marlin, D., Montuschi, P., Olin, A.C., Redington, A.E., Reinhold, P., van Rensen, E.L., Rubinstein, I., Silkoff, P., Toren, K., Vass, G., Vogelberg, C., Wirtz, H., 2005. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 26, 523-548. Hsieh, T.H., Yu, C.P., Oberdorster, G., 1999. Modeling of deposition and clearance of inhaled Ni compounds in the human lung. Regul Toxicol Pharmacol 30, 18-28. IARC, 1990. Chromium, Nickel and welding. International Agency for Research on Cancer Monog Eval Carcinog Risk Hum 49, 1-677. IARC, 2006. Inorganic and Organic Lead Compounds. International Agency for Research on Cancer Monog Eval Carcinog Risk Hum 87, 1-519. IARC, I.A.f.R.o.C., 1993. Beryllium, Cadmium, Mercury and exposures in the glass manifacturing Industry. IARC, Lyon, France. 74
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UNIVERSITÀ DEGLI STUDI DI PARMA DO
Page 3 and 4:
Riassunto La raccolta e l’analisi
Page 5 and 6:
Sommario CAPITOLO 1: Introduzione .
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5.3.1 Scopi dello studio ..........
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Congressi Nazionali ed Internaziona
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ischio consiste nel caratterizzare
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1.1 I biomarcatori Il termine “bi
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Forschungsgemainschaft (DFG, 2004).
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elettrotermico (ETAAS) fino ad arri
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E’ possibile studiare la cinetica
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Tra le molecole dosate con maggior
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circostanze, sarebbe più appropria
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3.3.2 Miscele di inquinanti comples
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3.3.3.3 Elementi metallici nel BAL
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- Cromatura galvanica, che prevede
Page 31 and 32: Molti studi in vivo e in vitro hann
Page 33 and 34: tra tessuto sano e malato (Raithel
Page 35 and 36: 4.3.2 Cd e il fumo di sigaretta Le
Page 37 and 38: sulla sintesi dell’eme. I valori
Page 39 and 40: - Smontaggio, pulitura e deposito n
Page 41 and 42: 5.2.2.3 Le misure ambientali Le mis
Page 43 and 44: 5.2.3 Risultati I livelli di Cr mis
Page 45 and 46: di DPC in 1-butanolo e 100 μl di H
Page 47 and 48: 5.4 Un terzo studio confermativo ne
Page 49 and 50: 5.5 Cr nel tessuto polmonare e nel
Page 51 and 52: I livelli di Cromo erano 0.14 (0.04
Page 53 and 54: - Monitoraggio ambientale: è stato
Page 55 and 56: 6.2 Nichel, Cadmio e Piombo esalati
Page 57 and 58: CAPITOLO 5: Discussione 7. Esposizi
Page 59 and 60: Cr(VI) nel CAE rinforza l’ipotesi
Page 61 and 62: Se nell’urina viene escreta una m
Page 63 and 64: sigaretta (Rustemeier et al., 2002;
Page 65 and 66: Cr(VI) nell’indurre risposte corr
Page 67 and 68: sul passaggio di Cr nei due stati d
Page 69 and 70: depositarsi ad alte concentrazioni
Page 71 and 72: Poiché il volume esalato non è al
Page 73 and 74: 11.8 Conclusioni Il sistema appare
Page 75 and 76: Amorim, L.C., de Cardeal, L.Z., 200
Page 77 and 78: Bernard, A., 2004. Renal dysfunctio
Page 79 and 80: Coogan, T.P., Squibb, K.S., Motz, J
Page 81: Effros, R.M., Hoagland, K.W., Bosbo
Page 85 and 86: Microscopic analysis of chromium ac
Page 87 and 88: McGarvey, L.P., Dunbar, K., Martin,
Page 89 and 90: NIOSH, 2003. NIOSH Method 7703: Hex
Page 91 and 92: Rahman, I., Kelly, F., 2003. Biomar
Page 93 and 94: Tatrai, E., Kovacikova, Z., Hudak,
Page 95 and 96: 13. Tabelle 86
Page 97 and 98: Controlli Lavoratori N° soggetti 2
Page 99 and 100: N° soggetti 10 Sesso (M/F) 10/0 La
Page 101 and 102: Cr-Plasma (μg/L) Cr-RC (ng/10 9 ce
Page 103 and 104: Controlli NSCLC tempo 1 NSCLC tempo
Page 105 and 106: Ni-Aria Lunedì (μg/m 3 ) Ni-U Lun
Page 107 and 108: Composizione SERETIDE® 0.3-0.5 mic
Page 109 and 110: Figura 1: Tavola periodica degli el
Page 111 and 112: Figura 3. Meccanismi di tossicità
Page 113 and 114: Figura 5. (A) Cromatura Galvanica -
Page 115 and 116: Cr-CAE (μg/L) 100 10 1 0.1 r=0.25,
Page 117 and 118: mAbs a 540/545 nm : r = 0.9999, int
Page 119 and 120: A Cr-CAE (μg/L) Cr(VI)/Cr TOT B 10
Page 121 and 122: Cr-U (μg/g creat.) 7 6 5 4 3 2 1 0
Page 123 and 124: 1 0.1 Cr-CAE (μg/L) log(Cr-CAE) =
Page 125 and 126: Cr Tessuto (μg/g tessuto secco) 1
Page 127 and 128: Ni-CAE (μg/L) 10 1 r=-0.11, p=ns 1
Page 129 and 130: Ni-CAE (μg/L) Cd-CAE (μg/L) Pb-CA
Page 131 and 132: Figura 23: Modello teorico che desc
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Figura 25: deposizione polmonare ne
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Figura 27: distribuzione delle part
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Figura 29: andamento della concentr
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Figura 31: il segnale così come mi
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Flusso (L/s) 0.5 0.4 0.3 0.2 0.1 0.
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Particelle 1.0 micron (Part/L) 1400
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Pubblicazioni scientifiche nazional
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Altre attività e pubblicazioni, An
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Eurotox 2006 - 43 rd congress of th
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• Goldoni Matteo, Caglieri A, Pol
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Allegato I I
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Materials and Methods Subjects. Tab
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280 μL at T 2) and controls (1,585
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Allegato II II
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230 M. Goldoni et al. / Analytica C
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Page 165 and 166:
Page 167 and 168:
Allegato III III
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488 Int Arch Occup Environ Health (
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Page 173 and 174:
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Allegato IV IV
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CHEST Original Research Exhaled Met
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Subject Characteristics Materials a
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Figure 1. Lead, cadmium, aluminum (
Page 183 and 184:
Figure 3. Iron (expressed in log 10
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dedicated to elemental analysis, an
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Exhaled Metallic Elements and Serum
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