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THE VAN BEKKUM STEM CELL AWARD Professor Hans Kolb is the third recipient of this award that is bestowed on individuals who have made major contributions for a prolonged period of time to the field of hematopoietic stem cells <strong>and</strong> <strong>transplantation</strong>. ix
Page 1: AUTOLOGOUS BLOOD AND MARROW TRANSPL
Page 5 and 6: AUTOLOGOUS BLOOD AND MARROW TRANSPL
Page 7: ACKNOWLEDGMENTS We wish to thank Wi
Page 13 and 14: CHAPTER 1: AML TABLE OF CONTENTS 4H
Page 15 and 16: Table of Contents Autografting for
Page 17 and 18: Table of Contents xv VACOP-B Plus A
Page 19 and 20: Table of Contents xvii High Dose Se
Page 21 and 22: Table of Contents Autologous Blood
Page 23 and 24: Table of Contents Stem Cell Reinfus
Page 25: CHAPTER 15: NEW AVENUES Table of Co
Page 28 and 29: xxvi List of Abbreviations CAV cisp
Page 30 and 31: xxviii List of Abbreviations I IBC
Page 32 and 33: xxx List of Abbreviations PSS progr
Page 35: CHAPTER 1 AML
Page 38 and 39: 4 Chapter 1: AML contribute to rela
Page 40 and 41: 6 Chapter 1: AML Table 1. Purging e
Page 42 and 43: 8 Chapter 1: AML graft. We plan to
Page 44 and 45: 10 Chapter 1: AML years that a sign
Page 46 and 47: 12 Chapter 1: AML Subgroup Risk gro
Page 48 and 49: 14 Chapter 1: AML 2. Zittoun RA, Ma
Page 50 and 51: 16 Chapter I: AML placebo-controlle
Page 52 and 53: 18 Chapter 1: AML 6. Hellstrand K,
Page 54 and 55: 20 Chapter 1: AML apheresis after G
Page 56 and 57: 22 Chapter 1: AML Table 1. Clinical
Page 58 and 59: 24 Chapter 1: AML exhibit low-densi
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26 Chapter 1: AML Disease-Free Surv
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28 Chapter 1: AML Disease-Free Surv
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30 Chapter 1: AML 2 CO Disease-Free
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32 Chapter 1:AML Table 3. Probabili
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34 Chapter 1: AML Eric Martin (Medi
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36 Chapter 1: AML 23. Howell AL, Ba
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Autologous Blood Cell Transplantati
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40 Chapter 1: AML quarter of the pa
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42 Chapter 1: AML of the EBMT. 32 A
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44 Chapter 1: AML 7. O'Donnell MR,
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Immunotherapy With IL-2 After Autol
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48 Chapter 1: AML Several centers h
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50 Chapter 1 : AML occur within the
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52 Chapter 1: AML Information Scien
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CHAPTER 2 ALL
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58 Chapter 2: ALL Table 1. Comparis
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60 Chapter 2: ALL UKALL XII). This
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Adult ALL: BMT in First Remission f
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64 Chapter 2: ALL leukemia) appears
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66 Chapter 2: ALL recent update, ho
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68 Chapter 2: ALL in parallel, and
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70 Chapter 2: ALL A, Prentice G, Gl
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Autologous Hematopoietic Stem Cell
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74 Chapter 2: ALL Table 1. Patient
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76 Chapter 2: ALL Table 3. Hematolo
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78 Chapter 2: ALL 1,0 i j CR3 (n= 3
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80 Chapter 2: ALL 20 40 60 < 5 week
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82 Chapter 2: ALL Other aspects reg
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Autologous BMT/PBSCT in BCR-ABL-pos
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86 Chapter 2: ALL ABMT/PBSCT in CR2
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88 Chapter 2: ALL Induction I Induc
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90 Chapter 2: ALL CONCLUSIONS Molec
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92 Chapter 2: ALL Adult Philadelphi
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94 Chapter 2: ALL BMT. Transplantat
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96 Chapter 2: ALL Table 1. Summary
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98 Chapter 2: ALL 5:01 2.5:1 1.25:1
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100 Chapter 2: ALL 11. Passweg JR,
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Donor Lymphocyte Infusions Produce
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Carella et al. later, and the other
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Carella et al. Evaluation of chimer
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Carella et al. erythropoietin follo
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Autografring for Chronic Myeloid Le
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Preclinical Evaluation of an Inhibi
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Hehlmann et al. 115 idarubicin, Ara
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BMT Hehimann et ai. 117 Diagnosis /
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Hehlmann et al. 119 Table 4. Correl
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Allocation: suitable for transplant
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Hehlmann et al. 123 2. The Italian
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Br J Haematol 23:283-288,1972. Hehl
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Hehlmann et al. 127 JA, Dexter TM,
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Carlo-Stella et al. 129 INTRODUCTIO
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Carlo-Stella et al. 131 DNA fragmen
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Carlo-Stella et al. 133 particularl
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Carlo-Stella et al. 135 10. De Fabr
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CHAPTER 4 LYMPHOMA
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Late Non-Relapse Mortality After Au
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142 Chapter 4: Lymphoma Table 2. Tr
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144 Chapter 4: Lymphoma 1.0 1 0.4 J
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146 Chapter 4: Lymphoma after autoS
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148 Chapter 4: Lymphoma etoposide f
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150 Chapter 4: Lymphoma age, sex, d
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152 Chapter 4: Lymphoma Mobilizatio
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154 Chapter 4: Lymphoma Missing dat
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156 Chapter 4: Lymphoma Table 3. Ef
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158 Chapter 4: Lymphoma REFERENCES
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160 Chapter 4: Lymphoma Blood 79:10
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162 Chapter 4: Lymphoma Gribben et
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164 Chapter 4: Lymphoma purging. Si
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Local and Regional Recurrence After
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168 Chapter 4: Lymphoma and autoSCT
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170 Chapter 4: Lymphoma Local or lo
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172 Chapter 4: Lymphoma %OS 100 i 8
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174 Chapter 4: Lymphoma %os 100. 80
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176 Chapter 4: Lymphoma A 100 % RFS
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178 Chapter 4: Lymphoma 100 80 %OS
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180 Chapter 4: Lymphoma vs. sensiti
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182 Chapter 4: Lymphoma therapy wit
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High-Dose Therapy Followed by Hemat
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186 Chapter 4: Lymphoma autoBMT in
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188 Chapter 4: Lymphoma diameter. R
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190 Chapter 4: Lymphoma 3. Fisher R
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VACOP-B Plus Autologous Bone Marrow
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194 Chapter 4: Lymphoma sequential
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196 Chapter 4: Lymphoma Study desig
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198 Chapter 4: Lymphoma 100 90 80 .
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200 Chapter 4: Lymphoma Patients we
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202 Chapter 4: Lymphoma 19. Fisher
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Total Therapy With Tandem Transplan
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Immune-Based Strategies to Improve
Page 243 and 244:
Schlossman et al. (sB2M), stage I d
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Schlossman et al. 211 cells are rem
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Schlossman et al. 213 Cohorts of pa
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Schlossman et al. 215 Disease-free
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Schlossman et al. 217 taken advanta
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Schlossman et al. Hematol 34:49-60,
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Schlossman et al. 221 41. Giralt S,
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Harousseau and Attal 223 were rando
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Harousseau and Altai 225 II—III M
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Harousseau and Attal 227 Table 1. I
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Harousseau and Attal Table 2. IFM 9
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Syngeneic Transplantation in Multip
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Gahrton et al. 233 patients were ma
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Pretreatment With Alkylating Agents
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Table 1. Patient characteristics Nu
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Kiel et al. Figure 1. Quantitative
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Kiel et al. 2 4 6 8 10 12 Number of
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3:316-323,1997. Kiel et al. 243 6.
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CHAPTER 6 BREAST CANCER
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248 Chapter 6: Breast Cancer cells
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250 Chapter 6: Breast Cancer breast
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252 Chapter 6: Breast Cancer 10 n p
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254 Chapter 6: Breast Cancer the ex
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Detection of Cytokeratin + Cells in
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258 Chapter 6: Breast Cancer cytoke
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260 Chapter 6: Breast Cancer Table
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264 Chapter 6: Breast Cancer minati
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266 Chapter 6: Breast Cancer 18 mon
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268 Chapter 6: Breast Cancer Tumor
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270 Chapter 6: Breast Cancer Figure
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272 Chapter 6: Breast Cancer cultur
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Tandem PBSC-Supported High-Dose The
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276 Chapter 6: Breast Cancer breast
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278 Chapter 6: Breast Cancer effica
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280 Chapter 6: Breast Cancer BSC Ha
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282 Chapter 6: Breast Cancer proced
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Page 320 and 321:
286 Chapter 6: Breast Cancer In 24
Page 322 and 323:
288 Chapter 6: Breast Cancer Cancer
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High-Dose Chemotherapy With Autolog
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Page 328 and 329:
294 Chapter 6: Breast Cancer receiv
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296 Chapter 6: Breast Cancer of res
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298 Chapter 6: Breast Cancer obtain
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300 Chapter 6: Breast Cancer high-d
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302 Chapter 6: Breast Cancer effect
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304 Chapter 6: Breast Cancer three
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306 Chapter 6: Breast Cancer patien
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308 Chapter 6: Breast Cancer separa
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Page 346 and 347:
312 Chapter 6: Breast Cancer 1.0-1
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314 Chapter 6: Breast Cancer c JS S
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316 Chapter 6: Breast Cancer 2 O X
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318 Chapter 6: Breast Cancer progre
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320 Chapter 6: Breast Cancer C 1.0-
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Page 358 and 359:
Page 360 and 361:
326 Chapter 6: Breast Cancer An out
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328 Chapter 6: Breast Cancer 4. Can
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330 Chapter 6: Breast Cancer 33. Ov
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An Aggressive Approach to Metastati
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334 Chapter 6: Breast Cancer CD O 1
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336 Chapter 6: Breast Cancer 1.0
Page 372 and 373:
Sequential High Dose Chemotherapy f
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340 Chapter 6: Breast Cancer 10. He
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342 Chapter 6: Breast Cancer conclu
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344 Chapter 6: Breast Cancer after
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Page 382 and 383:
348 Chapter 6: Breast Cancer re > '
Page 384 and 385:
350 Chapter 6: Breast Cancer BM K-1
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352 Chapter 6: Breast Cancer regime
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354 Chapter 6: Breast Cancer 1988 1
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356 Chapter 6: Breast Cancer Doceta
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Page 394 and 395:
360 Chapter 6: Breast Cancer DIFFER
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Expression of C-ErbB-2/Her-2 in Pat
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364 Chapter 6: Breast Cancer MATERI
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366 Chapter 6: Breast Cancer weeks.
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368 Chapter 6: Breast Cancer (P=0.0
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370 Chapter 6: Breast Cancer result
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372 Chapter 6: Breast Cancer ACKNOW
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374 Chapter 6: Breast Cancer apy in
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High-Dose Chemotherapy and Autologo
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Stiff, Kerger, and Bayer 379 75 mg/
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Table 1. Clinical characteristics S
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Survival 1.00 .80 4 .60 i .40 1 .20
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Stiff, Kerger, and Bayer 385 patien
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57:278-285,1995. Stiff, Kerger, and
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Abonour et al. 389 INTRODUCTION Wit
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Abonour et al. 391 A more recent ex
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Abonour et al. 393 DFS by Prognosti
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Abonour et al. 395 6. Motzer RJ, Co
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Leyvraz et al. 397 Table 1. Results
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Table 3. ICE toxicity (172 cycles)
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Leyvraz et al. 401 intensive treatm
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Elias et al. (CAV) and with etoposi
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Elias et al. tumor, or in the case
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Elias et al. selection of patients
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Elias et al. partial purge of the a
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ProcASCO 16:456a, 1997. Elias et al
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Elias et al. late dose intensificat
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Elias et al. G, McCauley M, Gaynes
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Transplantation With PBSC, Manipula
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Takaue et al. 419 transfusion (day
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Takaue et al. All tation, this proc
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Rodenhuis et al. 423 INTRODUCTION H
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mg/m 2 Rodenhuis et al. 425 in pati
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Rodenhuis et al. All interest. One
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Rodenhuis et al. 429 Figure 2. Prog
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c 1000 -I Rodenhuis et al. 0 4 8 Ti
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Rodenhuis et al. 433 First, a respo
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Epirubicin Plus G-CSF-Elicited Peri
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Carlo-Stella et al. 437 tissues fro
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Carlo-Stella et al. 439 Epi 1 20 mg
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A 140 -i 120- _i 100- CO 80 - O 60
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Carlo-Stella et al. immediately evi
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lastomas. Anticancer Drugs 8:174-18
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CHAPTER 8 AUTOIMMUNE DISEASE
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450 Chapter 8: Autoimmune Disease u
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Autologous Blood Stem Cell Therapy
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454 Chapter 8: Autoimmune Disease T
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456 Chapter 8: Autoimmune Disease w
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Page 494 and 495:
Page 496 and 497:
Page 498 and 499:
Hematopoietic Stem Ceil Transplanta
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466 Chapter 8: Autoimmune Disease i
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468 Chapter 8: Autoimmune Disease s
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470 Chapter 8: Autoimmune Disease 1
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Autologous Stem Cell Therapy in Aut
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Page 510 and 511:
Autologous Hematopoietic Stem Cell
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Page 514 and 515:
480 Chapter 8: Autoimmune Disease r
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Presence in Pretransplant Marrow of
Page 519 and 520:
Table 1. Study 1 patient characteri
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Radford et al. 487 1 2 3 4 5 6 7 8
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Radford et al. 489 transplantation,
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Importance of Marrow Doses and Mode
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Gorin TC 199 medium and finally fro
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Gorin 495 ABMT IN AL Engraftment on
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Gorin Table 5. Engraftment accordin
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Gorin 499 ABMT IN AL Outcome in rel
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OS% Gorin 501 1 1 1 • • 0 i 1 1
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Gorin 503 S, Carlier P, Giordano D,
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15:769-775, 1995. Gorin 505 35. Dou
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Long-Term Observations Following He
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Deeg et al 509 Table 2. Secondary m
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Gene Marking to Assess Tumor Contam
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Heslop et al. 515 clonogenic assays
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Heslop et al. 517 Disease Free Surv
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Heslop et al. 519 providing the cli
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Enrichment of Tumor Cells From Auto
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Ross et al. post-TEC fraction was c
Page 559 and 560:
Ross et al. 525 Table 2. Results of
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Ross et al. that the capture antibo
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Combining Positive/Negative Selecti
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Mapara et al. 531 products of patie
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Mapara et al. 533 Hematopoietic col
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Mapara et al. 535 A i m : P u r g i
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Mapara et al. 537 A |_ «••«
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Mapara et al. 539 11. Shpall EJ, Le
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Tumor Purging Technologies: More Qu
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Gee 543 argued that these two patie
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Gee 545 immunomagnetic particles to
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Gee 547 POSITIVE OR NEGATIVE? Given
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Gee 549 autologous transplants of c
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Behavior of Hematopoietic Stem Cell
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Henschler et al. 553 MATERIALS AND
Page 589 and 590:
Table 1. Engraftment of human CD34
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Henschler et al. 557 an increase of
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Henschler et dl. 559 plantation for
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CD34 Selection and Autografting in
Page 597 and 598:
Table 1. Patient characteristics, n
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Voso et al. 565 The side scatter (S
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Table 3. Immunophenotype of CD34 +
Page 603 and 604:
Voso et al. 569 neuroblastoma and a
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Voso et al. 571 transplantation for
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Neutrophils Days 100 Days to >500
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Dicke et al. 575 CD34 Labeling Samp
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Dicke et al. 577 Table 3. Platelet
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Dicke et al. 579 3. Ager S, Scott M
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Janssen et al. 581 PBSC products. H
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Janssen et al. Table 1. Characteris
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5X10 5 Janssen et ai. 585 In brief,
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Janssen et al. CD34+ CELLS INFUSED/
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1.0 0.9 0.8 0.7 0.6 0.5 0.4 0.3 0.2
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Janssen et al. RELAPSE FREE SURVIVA
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CD34 + Janssen et al. cells and CFU
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Janssen et al. 595 8. Dercksen MW,
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Janssen et al. 597 32. Sosman JA, S
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CHAPTER 11 MINITRANSPLANTS
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602 Chapter 11: Minitransplants to
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604 Chapter 11: Minitransplants Tab
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608 Chapter 11: Minitransplants tra
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610 Chapter 11: Minitransplants 14.
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Allogeneic Progenitor Cell Transpla
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614 Chapter 11: Minitransplants 100
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Page 652 and 653:
618 Chapter 11: Minitransplants all
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Transduction of Primitive Hematopoi
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Jordan et al. shown that such a hyb
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Table 1. Initial findings with seve
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Jordan et al. In preclinical studie
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Molecular Intervention in Myeloma A
Page 665:
CHAPTER 13 IMMUNOTHERAPY
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Immune-toxins Containing Pokeweed A
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636 Chapter 13: Immunotherapy tumor
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638 Chapter 13: Immunotherapy unide
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640 Chapter 13: Immunotherapy lymph
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642 Chapter 13: Immunotherapy accom
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644 Chapter 13: Immunotherapy Figur
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646 Chapter 13: Immunotherapy CD80P
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648 Chapter 13: Immunotherapy are o
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650 Chapter 13: Immunotherapy 23. F
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652 Chapter 13: Immunotherapy 57. T
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Adjuvant Immunotherapy in Conjuncti
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656 Chapter 13: Immunotherapy mg/m
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658 Chapter 13: Immunotherapy NHL a
Page 694 and 695:
660 Chapter 13: Immunotherapy tion
Page 696 and 697:
662 Chapter 13: Immunotherapy Table
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664 Chapter 13: Immunotherapy leuke
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The Brambell Receptor (FcRB) and th
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5h P 11- V Junghans 669 o I 1 1 1 1
Page 705 and 706:
Junghans 10 20 30 40 IgG Concentrat
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1001- 90 80 E 70 § 60 K g 50 u z 8
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Junghans 675 Time, days Figure 8. B
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Junghans 677 The site on Fc for int
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Junghans 679 1969. 20. Junghans RP,
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Approaches to the Radiation Dosimet
Page 717 and 718:
Fisher 683 bution to marrow dose is
Page 719 and 720:
Fisher 685 organ k per unit cumulat
Page 721 and 722:
Fisher 687 acetabulum. The curve is
Page 723 and 724:
Fisher 689 Table 2. Correlations be
Page 725 and 726:
Fisher 8. Sgouros G: Bone marrow do
Page 727:
Radioimmunotherapy for Malignant Ly
Page 731 and 732:
Induction of Graft-vs.-Malignancy a
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Champlin, Khouri, and Giralt 699 is
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Champlin, Khouri, and Girat 701 and
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Champlin, Khouri, and Giralt 703 ti
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Champlin, Khouri, and Giralt 705 A
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Champlin, Khouri, and Giralt 707 E,
Page 743 and 744:
Whimbey 709 INTRODUCTION Infectious
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Whimbey 711 CRVs are a common cause
Page 747 and 748:
Whimbey 713 antibody titers to RSV
Page 749 and 750:
Whimbey 715 toxic, less costly, and
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Asymmetric Division as Measurable P
Page 753:
Neuropoiesis Peter Quesenberry, Car
Page 757 and 758:
Summary: Leukemia John Barrett Bone
Page 759 and 760:
Barrett New directions A role for i
Page 761 and 762:
Autologous Blood and Marrow Transpl
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across page) Elfenbein 729 Examples
Page 765 and 766:
Elfenbein 731 Examples Contributors
Page 767 and 768:
Table 3. Types of clinical trials i
Page 769 and 770:
Strategies in Autologous Bone Marro
Page 771 and 772:
Summary: Lymphoma Armand Keating On
Page 773 and 774:
Rafat Abonour Indiana Univ. Cancer
Page 775 and 776:
H-Joachim Deeg Fred Hutchinson Canc
Page 777 and 778:
Richard P. Junghans Division of Hem
Page 779 and 780:
Peter J. Quesenberry Univ. of Massa
Page 781 and 782:
Linda T. Vahdat Columbia Presbyteri
Page 783 and 784:
DiStefano, Alfred 332 Dodero, Anna
Page 785 and 786:
Author Index 751 Ohno-Jones, S. 113
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KEY WORD INDEX 4-HC 1 Brambell rece
Page 789:
Refractory anemia with excess blast
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