autologous blood and marrow transplantation - Blog Science ...

100.
Martin, Atta, and Hoelzer 89
Pooled data from 10 centers (n=82)
_LL
L IL
Relapse =74 ±6 %
EFS=21.5+5.3%
4b 6b 72 9b 108
Months
Figure 4. Event-free survival and relapse after autologous BMT/PBSCT in BCR-ABL* ALL
(n=82). The Kaplan-Meier plots are based on pooled data from the references listed in Tabl
1 including the GMALL series.' 7
' 26
autologous transplantation in BCR-ABL +
ALL from other centers as listed in Table
1 17-26 jh e p 0 0i ed s e r i e s included 30 patients receiving unpurged grafts. There was
a trend but no significant difference for better event-free survival in favor of
purging. Patients receiving purged or unpurged grafts are labeled P or NP in Fig.
5, respectively.
ioo_
Pooled data from 10 centers (n=80)
1 L
P purged graft
NP not purged
TxinÇRI: EFS=27±7%
P "PP .„ NP
I P
n I
" PP
i_u
p=0.07
p p
1 1
Txin CRZ EFS=12±7%
0 15 2*4 36 48 6'0 72 8'4 96 108
Months
Figure 5. Event-free survival after autologous BMT/PBSCT in BCR-ABL+ ALL in (n=52)
or beyond (n=28) first CR. The Kaplan-Meier plots are based on pooled data from the references
listed in Table 1 including the GMALL series. The remission status beforetransplan
was not available in two patients from Table 1.