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750 Author Index Hurd, D.D. 483 Kuis, Wietse 476 Meagher, Richard C. 265 Hurd, David D. 275 Kutteh, Leila A. 149 Mehta, J. 205 Jacobs, Cindy 149 Kvalheim, Gunnar 161, 247 Meier, CR. 114 Jagannath, J. 205 Kvaloy, Stein 161 Meloni, Giovanna 39 Janssen, William E. 580 Labedzki, L. 114 Mertelsmann, Roland 551 Janvier, M. 279 Lafrenie, R. 362 Messinger, Yoav 633 Joly, Marguerite 719 Lambertenghi Deliliers, Miller, Carole B. 1 Jones, Richard J. 1 G. 231 Miller, J.S. 483 Jordan, Craig T. 621 Lange, A. 396 Miller, Kenneth 183 Junghahn, Ilse 551 Law, P. 717 Milligan, D.W. 231 Junghans, R.P. 667 Layton, T.J. 521 Millward, Michael J. 303 Kahn, Douglas G. 265 Lazarus, Hillard Möbest, Dieter 551 Kaiman, Leonard A. 275 M. 1, 149, 265, 275 Mogenstern, G.R. 139 Kaneko, Michio 417 Lazarus, Hillard 185 Mohm, J. 114 Kanfer, E. 103 Lee, S.M. 139 Montserrat, Emilio 72 Kapinas, Konstantin 452 Lentzsch, Suzanne 529 Moos, M. 235 Kata, D. 114 Leoni, Pietro 192 Moos, Marion 561 Kawano, Yoshifumi 417 Lerma, Enrica 104 Moraine, Staci 572 Kazis, Aristide 452 Levitzki, Alexander 128 Morelli, Julie 185 Keating, A. 735 Leyvraz, S. 396 Morr, Jody 185 Kennedy, M.J. 521 Lindemann, Albrecht 630 Morris, D. 362 Kerger, Christine 377 Lister, T.A. 139, 183 Moss, Thomas J. 265 Kessinger, A. 184 Ljungman, P. 231 Mück, R. 114 Keystone, Edward C. 449 Löffler, H. 114 Mugishima, Hideo 417 Khouri, Issa 612, 697 Lohrmann, H.-P. 114 Müller-Hagen, S. 114 Kiel, K. 235 Lydon, N.B. 113 Munoz, Luz 72 Kimiskidis, Vassilis 452 Lynch, J. 184 Munshi, N. 205 Klein, O. 114 Majolino, Ignazio 192 Murphy, Sandra C. 275 Klingemann, Malone, J. 184 Muus, Petra 39 Hans-G. 661,735 Mangoni, Lina 192, 435 Nadler, Lee 207 Ko, Y. 235 Mapara, Markus Y. 529 Nagler, Arnon 654 Koc, Omer N. 149 Marangolo, Maurizio 353 Nantel, Stephen 140 Koch, B. 114 Marín, Pedro 72 Naparstek, Ella 654 Köhler, Gabi 630 Marino, Gennaro 192 Nati, Sandra 192 Kolb, H.-J. 114 Martin, Hans 84 Naucke, S. 205 Kolstad, Arne 247 Martin, S. 274 NCIC-CTG Group 290 Körner, Ida J. 529 Martin, Simona 561 , Neri, C. 114 Krahulcova, E. 114 Martin-Henao, Gregorio 72 Nesland, Jahn M. 247 Krance, Robert A. 513 Masszi, T. 231 Neubauer, A. 114 Krause, S.W. 114 Matthews, J. 183 Neudorf, Stevan 19 Krause, Thomas 630 Mayr, A.C. 114 Nevill, Thomas 140 Kremers, S. 114 McCarthy Jr., Philip L. 275 Nichols, Craig R. 388 Kreuser, E.-D. 114 McGuinness, Michael 635 Nilsson, Bo 15 Kufe, Donald 207 Mckensen, Andreas 630 Noga, Stephen J. 265
Author Index 751 Ohno-Jones, S. 113 Regazzi, Ester 128, 435 Schmitz, Norbert 166 Olavarria, E. 103 Reiffers.J. 38,111,231 Schneeweiss, A. 274 Olivieri, Attilio 192 Reilly, Judy 719 Schneller, F. 114 Oppenhoff, P. 114 Rill, Donna R. 513 Schornagel, Jan H. 422 Or, Reuven 654 Rischin, Danny 303 Schouten, Harry C. 161 Orsini, Enrica 207 Ritz, Jerome 207 Schuhmacher, Axel 529 Ostrander, A.B. 521 Rizzoli, Schultze, Joachim 207 Palangié, T. 279 Vittorio 128, 192, 435 Schulz, Gregor 551 Palsson, B. 717 Roché, H. 279 Schweichler, Louis H. 332 Pampallona, S. 396 Rodenhuis, Sjoerd 422 Sertoli, Mario Roberto 192 Pang, Lizhen 719 Roginsky, Alexandra 464 Shamash, J. 139 Parodi, Caterina 104 Rohatiner, A.Z.S. 139, 183 Sharp, J.G. 521 Partyka, James S. 341,580 Rosen, O. 114 Shea, Thomas C. 149 Pasini, F. 396 Rosen, Steven 464 Shepherd, John 140 Passalacqua, Rodolfo 435 Rosenfeld, Craig 265 Shpall, E.J. 521 Pécora, Andrew L. 149, 265 Ross, A.A. 521 Siegel, D. 205 Pécora, Andrew 185 Rossi, Edoardo 192 Sierra, Jorge 72 Penza, Sam 265 Rosti, G. 396 Simonsson, Bengt 15 Perey, L. 396 Rosti, Giovanni 353 Simpson, David 661 Perkins, Janelle B. 341, 580 Rovira, Montserrat 72 Sing, Amy 149 Perry, J.J. 483 Rowe, Jacob M. 57 Singhai, S. 205 Pescosta, Norbert 192 Rowlings, Philip A. 275 Slavin, Shimon 654 Pettenati, M.J. 483 Rubagotti, Alessandra 192 Slovak, Marilyn L. 46 Pfirrmann, M. 114 Runde, Volker 39 Smartt, Pamela F.M. 166 Pforsich, Margit 561 Ryder, W.D.J. 139 Smilee, Renee C. 580 Phelps, Vicki 19 Sackstein, Robert 580 Smith, B. Douglas 1 Phillips, Gordon 140 Sakellari, Ioanna 452 Smith, S. 521 Porcellini, Adolfo 192 Salvagno, Luigi 192 Sniecinski, Irena 46 Powell, B.L. 483 Sammarelli, Gabriella 128 Sommer, Hilde 247 Powles, R.L. 231, 506 Samson, D. 231 Soracco, Monica 192 Pralle, H. 114 Sanders, Spiekermann, K. 114 Preti, Robert A. 265 Lieke (E.) A.M. 476 Spoon, D. 205 Prilutskaya, Marina 265 Sandmaier, Brenda M. 601 Spriano, Mauro 192 Prince, H. Miles 303 Santini, Gino 192 Spyridonidis, QueiBer, W. 114 Savarese, Todd 719 Alexandres 551 Quesenberry, P.J. 718 Savoldo, Barbara 128 Stadtmauer, Edward 185 Quesenberry, Peter 719 Sawyer, J. 205 Stefka, Jakub 464 Radford, J.A. 139 Sayer, H.G. 114 Stein, Anthony S. 46 Radford, J.E. Jr. 483 Scarffe, J.H. 139 Steins, M. 114 Rainer, R.O. 483 Scheding, S. 114 Stenzel-Johnson, P. 521 Raje, NooPur 207 Scheid, C. 114 Stewart, A.K. 629 Rao, P.N. 483 Schenkein, David P. 185 Stewart, D. 362 Raptis, Anastasios 661 Schlenk, R.F. 274 Stewart, Doug 290 Reece, Donna E. 140 Schlossman, Robert 207 Stewart, F.M. 718
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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ACKNOWLEDGMENTS We wish to thank Wi
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THE VAN BEKKUM STEM CELL AWARD Prof
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xii Table of Contents CHAPTER 2: AL
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xiv Table of Contents Late Non-Rela
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xvi Table of Contents Pretreatment
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xviii Table of Contents CHAPTER 7:
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XX Table of Contents Long-Term Obse
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xxii Table of Contents CHAPTER 13:
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0-9 LIST OF ABBREVIATIONS 2CDA 2-ch
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List of Abbreviations xxvii EFS eve
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List of Abbreviations MOPP mechlore
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VOD veno-occlusive disease VPC viru
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4HC-Purged Autologous Stem Cell Tra
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1.0-1 + 0.2 Miller et al. 5 Event F
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Miller et al. Adjusted probability
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Who Benefits From Autograft in AML
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Burnett 11 which to set the transpl
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Table 1. Outcome after relapse in M
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Immunotherapy in AML: No Positive E
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Simonsson et al. inhibit IL-2 induc
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Autologous Bone Marrow Transplantat
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Ball et al. 21 CD15) and AML-2-23 (
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Ball et al. 23 The ex vivo treatmen
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Ball et al. 25 Table 2. Factors inv
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Ball et al. Overall Survival for Pa
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Ball et al. Overall Survival for Pa
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Ball et al. 31 Overall Survival for
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Ball et al. Table 4. Actuarial over
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Ball et al. myeloid leukemia. The G
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Ball et al. 1993. 38. Mehta J, Powl
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Can Autologous Stem Cell Transplant
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De Witte et al. 41 novo AML. Auer r
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De Witte et al. hematopoietic engra
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De Witte et al. 23. Fenaux P, Laï
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Stein et al. and fever. No patient
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Stein et al. after doses 1, 3, and
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Stein et al. early after the transp
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autologous stem-cell rescue. / Clin
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Bone Marrow Transplantation for Acu
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Table 2. Autologous BMT in ALL in f
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Rowe 61 or adult patients with acut
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Hoelzer and Gôkbuget minitransplan
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Hoelzer and Gdkbuget 65 blood, earl
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Table 3. Risk factors for the defin
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Hoelzer and Gôkbuget treatment opt
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Hoeker and Gökbuget tical sibling
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Sierra et al. INTRODUCTION Two-thir
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Sierra et al. Table 2. Adverse char
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1,0 0,0 J Sierra et al. 0 20 40 60
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Sierra et al. Months Figure 4 < 30,
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Sierra et al. No adverse factors (n
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1994. Sierra et al. 83 10. Canals C
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Martin, Atta, and Hoelzer 85 adult
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Martin, Atta, and Hoelzer 87 Single
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100. Martin, Atta, and Hoelzer 89 P
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Martin, Atta, and Hoelzer 91 chromo
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Autologous vs. Unrelated Allogeneic
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Boyer and Yeager 95 outcomes after
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Boyer and Y eager 97 Table 2. Hypot
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Boyer and Y eager SUMMARY Most of t
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CHAPTER 3 CML
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Autograft Followed by Allograft Wit
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106 Chapter 3: CML (one low-grade a
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108 Chapter 3: CML DISCUSSION Myelo
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110 Chapter 3: CML Philadelphia-neg
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The Case for Manipulation of CML Au
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Toward a Cure by Drug Treatment? Th
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116 Chapter 3 :CML Table 1. Prolong
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118 Chapter 3: CML Table 3. German
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120 Chapter 3: CML Table 5. Normal
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122 Chapter 3: CML Table 8. Surviva
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124 Chapter 3: CML 88:3118-3122, 19
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126 Chapter 3: CML RK, Klingemann H
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The Tyrphostin AG957 Inhibits the I
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130 Chapter 3: CML mobilization. Al
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132 Chapter 3: CML A B 100 n 0 1 5
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134 Chapter 3: CML The in vitro sel
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136 Chapter 3: CML detecting leukem
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Progressive Hodglcin's Lymphoma Fol
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Reece et al. survival is observed i
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0.2 -I 0.0 0 Reece et al. 143 ii i
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Reece et al. Table 3. Causes of non
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Reece et al. carmustine, etoposide
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CD34 + Selection of Hematopoietic B
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Lazarus et al. 151 significantly de
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Lazarus et al. 153 (Sigma, St Louis
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Lazarus et al. 155 Table 2. Effect
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Lazarus et al. 157 difference. Furt
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Lazarus et al. 159 cells after myel
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The European CUP/UP Trial: A Prelim
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Table 1. Patient characteristics at
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Schouten et al. licular non-Hodgkin
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Sweetenham et al. vs. autologous pe
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Table 1. Patient characteristics, g
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Table 2. Patient characteristics, g
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Table 3. Sites of relapse, group A
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Table 4. Patterns of relapse, group
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A 100 80 %OS 60 40 20 B 100 %OS | S
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Sweetenham et al. new sites, and fi
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Sweetenham et al. Treatment options
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Molecular Remission: A Worthwhile A
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Early or Late Autotransplant in Hig
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Schenkein et al. 187 PATIENTS AND M
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Schenkein et al. 189 Toxicity Toxic
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Schenkein et al. 191 16. Glick JH,
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Santini et al. 193 to evaluate the
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Table 1. Continued Santini et al. 1
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Santini et al. 197 cytosine arabino
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1 0 0 1 90- 80- 70- (0 u. 60' o so-
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Hodgkin's lymphoma. N EnglJ Med 333
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CHAPTER 5 MYELOMA
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206 Chapter 5: Myeloma independent
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208 Chapter 5: Myeloma disease (MRD
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210 Chapter 5: Myeloma Scandinavia,
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212 Chapter 5: Myeloma (0 n o B co
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214 Chapter 5: Myeloma B cq d ? o c
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216 Chapter 5: Myeloma patients wit
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218 Chapter 5: Myeloma PBSC transpl
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220 Chapter 5: Myeloma 25. Seiden M
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Autologous Transplantation in Multi
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224 Chapter 5: Myeloma 0 52 44 U §
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226 Chapter 5: Myeloma BM ^ (CD34±
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228 Chapter 5: Myeloma IFM 94 : OS
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230 Chapter 5: Myeloma two groups a
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232 Chapter 5: Myeloma increase bot
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234 Chapter 5: Myeloma REFERENCES 1
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236 Chapter 5: Myeloma Intensified
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238 Chapter 5: Myeloma of CD34 + ce
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Chapter 5: Myeloma Table 2. Descrip
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242 Chapter 5: Myeloma o 8H 0 2 4 6
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244 Chapter 5: Myeloma ated with sh
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The Presence of Micrometastases in
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Kvalheim et al. 249 Table 1. Immuno
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Kvalheim et al. 251 Figure 1. Sixty
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Kvalheim et al. 253 DISCUSSION In t
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Kvalheim et al. 255 Bastert G: Micr
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Hood et al. 257 In an effort to inc
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#CD34 + cells in blood = Hood et al
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Hood et al. 261 Table 3. Frequency
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Hood et al. 263 REFERENCES 1. Rill
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The Clinical Significance of Breast
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Moss et al. tests, and bilateral po
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Moss et al. 269 0 15 70 143 200 400
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Moss et al. 271 0 3 6 12 18 24 30 3
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Moss et al. 273 8. Passos-Coelho J,
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Autotransplantation for Men With Br
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McCarthy et al. 277 radiation, two
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High Dose Sequential Chemotherapy W
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Viens et al. 281 3 g/m 2 and doxoru
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Table 1. Tumor characteristics Exte
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Table 4. Response Viens et al. 285
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Viens et al. 287 Table 5. Pathologi
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Viens et al. 289 apy for inoperable
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Gliick et al. 291 INTRODUCTION The
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Gluck et al. 293 RESULTS Patient de
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Glück et al. 295 Table 3. Response
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Gluck et al. 297 Overall Survival O
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Gluck et al. 299 Sudbury patients w
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Gluck et al. 301 anthracycline or t
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Repetitive High-Dose Therapy With P
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Prince et al. paramagnetic separati
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Prince et al. Table 1. High-dose re
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Table 2. Patient characteristics (n
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Table 4. Hematopoietic recovery fol
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1.0- M C .S 0.8- a c *fe o o> 0.6-
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M 1.0 I 0.8H s? VI o.6H S 0.2 0.0 P
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a Prince et al. days to platelets >
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Table 5. Results of Isolex 300i CD3
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Prince et al. 321 Figure 5, continu
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Prince et al. 323 months after tran
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Prince et al. 325 excessive to be u
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Prince et al. 327 eight patients ha
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Prince et al. 329 marrow transplant
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Prince et al. intensive chemotherap
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-Q CO .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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.Q CD .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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oba Q. 1.0 0.9 Dicke et al. Stage I
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Vahdat with peripheral blood progen
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Evaluation of Prognostic Factors fo
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Fields et al. 343 PATIENTS AND METH
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Table 1. Chemotherapy regimens. Fie
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Fields et al. Stage II; 4-9 Pos LN
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U U Fields et al.
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Fields et al. 351 between 1 and 2 y
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European Trends and the EBMT Databa
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25% % 22% / 17% \ Rosti et al. 355
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Rosti et al. 357 The new Italian St
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Rosti et al. 6. Haas R, Schmid H, H
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Bewick et al. 363 INTRODUCTION The
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Bewick et al. 365 Blood samples obt
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Bewick et al. 367 HDCT with ABSC su
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Bewick et al. Progression Free Surv
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Bewick et al. pression in MBC, i.e.
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Bewick et al. 14. Kandl HL, Seymour
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CHAPTER 7 OTHER SOLID TUMORS
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378 Chapter 7: Solid Tumors INTRODU
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380 Chapter 7: Solid Tumors Prepara
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382 Chapter 7: Solid Tumors Surviva
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384 Chapter 7: Solid Tumors months
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386 Chapter 7: Solid Tumors have be
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High-Dose Chemotherapy in the Manag
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390 Chapter 7: Solid Tumors followe
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392 Chapter 7: Solid Tumors Table 1
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394 Chapter 7: Solid Tumors (mucosi
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Three-Fold Intensification by Seque
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High-Dose Therapy for Small Cell Lu
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404 Chapter 7: Solid Tumors chemoth
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406 Chapter 7: Solid Tumors SCLC ha
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408 Chapter 7: Solid Tumors relapse
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410 Chapter 7: Solid Tumors 69:585-
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412 Chapter 7: Solid Tumors ogous b
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414 Chapter 7: Solid Tumors 64. Bru
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416 Chapter 7: Solid Tumors Prignot
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418 Chapter 7: Solid Tumors CO > CO
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420 Chapter 7: Solid Tumors TANDEM
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Multiple Courses of Cyclophosphamid
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424 Chapter 7: Solid Tumors and the
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426 Chapter 7: Solid Tumors Thiotep
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430 Chapter 7: Solid Tumors E 100 0
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432 Chapter 7: Solid Tumors course
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434 Chapter 7: Solid Tumors boplati
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436 Chapter 7: Solid Tumors INTRODU
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438 - Chapter 7: Solid Tumors Table
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440 Chapter 7: Solid Tumors seeded
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442 Chapter 7: Solid Tumors DISCUSS
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444 Chapter 7: Solid Tumors 10. Di
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446 Chapter 7: Solid Tumors plasma
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Autologous Stem Cell Transplantatio
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Keystone 451 hypertension, anemia,
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Fassas et al. 453 INTRODUCTION Mult
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Fassas et al. Table 2. Stem cell mo
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Table 3. Toxicity after stem cell i
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Fassas et al. Table 5. Trial 1: cha
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Fassas et al. MS PROGRESSION FREE S
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Fassas et al. ic or autologous bone
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1 2 1 6 EAE. Burt et al. 465 Becaus
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Burt et al. Since cyclophosphamide
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Burt et al. 469 toxicity study, we
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Burt et dl. All 23. Mor F, Cohen IR
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Hasler, Gratwohl, and Tyndall an ev
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Hasler, Gratwohl, and Tyndall 475 B
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Kuis, Wulffraat, and Sanders 477 st
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Kuis, Wulffraat, and Sanders neousl
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CHAPTER 9 LONG-TERM EFFECTS
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484 Chapter 9: Long-Term Effects po
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486 Chapter 9: Long-Term Effects Ta
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488 Chapter 9: Long-Term Effects ml
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490 Chapter 9: Long-Term Effects 4.
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492 Chapter 9: Long-Term Effects us
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494 Chapter 9: Long-Term Effects AB
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Page 532 and 533:
498 Chapter 9: Long-Term Effects En
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500 Chapter 9: Long-Term Effects Rl
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502 Chapter 9: Long-Term Effects RE
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504 Chapter 9: Long-Term Effects A,
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Long-Term Follow-Up of Autologous T
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CHAPTER 10 GRAFT MANIPULATION
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514 Chapter 10: Graft Manipulation
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Stem Cell Reinfusion Over Two Conse
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Final Report of the First Prospecti
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Canine Hematopoietic Stem Allograft
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Sandmaier et al. 603 The resultant
Page 639 and 640:
Sandmaier et al. 605 synthesis path
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Sandmaier et al. 607 interactions o
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Sandmaier et al. 1991. 2. Burchenal
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87:3508-3513,1996. Sandmaier et al.
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Giralt, Khouri, and Champlin Table
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Giralt, Khouri, and Champlin seven
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1.0 3 0.2 Giralt, Khouri, and Champ
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CHAPTER 12 GENE THERAPY
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622 Chapter 12: Gene Therapy INTROD
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624 Chapter 12: Gene Therapy RESULT
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626 Chapter 12: Gene Therapy envisi
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628 Chapter 12: Gene Therapy cer in
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A Vaccine of Melanoma Peptide Loade
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B43(anti-CD 19)-Gen i stein Immunot
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Targeting Immunotherapy for the Tre
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McGuinness andArceci 637 modified m
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McGuinness andArceci 639 leukemic c
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McGuinness and Arced 641 in G418. T
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McGuinness andArceci 643 Figure 2
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mRNA for hB7-1 (1491 bp) mRNA for C
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McGuinness and Arced CD80PE C080PE
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McGuinness andArceci 649 8. Robert
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McGuinness andArceci immune respons
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McGuinness andArceci 75. Jubinsky F
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Slavin et al. 655 up suggests, as p
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Slavin et al. 657 was a phase lib c
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Slavin et al. presented, appears to
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Antitumor Immunotherapy in Autologo
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Klingemann et al. 663 Table 3. Meth
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CHAPTER 14 RADIOIMMUNOTHERAPY
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668 Chapter 14: Radioimmunotherapy
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Selection of Radioisotopes, Chelate
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Radioimmunotherapy of Common Epithe
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CHAPTER 15 NEW AVENUES
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698 Chapter 15: New Avenues Table 1
Page 734 and 735: 700 Chapter 15: New Avenues An alte
Page 736 and 737: 702 Chapter 15: New Avenues who can
Page 738 and 739: 704 Chapter 15: New Avenues myeloid
Page 740 and 741: 706 Chapter 15: New Avenues 48. Gir
Page 742 and 743: Emerging Viral Infections in Blood
Page 744 and 745: 710 Chapter 15: New Avenues influen
Page 746 and 747: 712 Chapter 15: New Avenues Among a
Page 748 and 749: 714 Chapter 15: New Avenues physica
Page 750 and 751: 716 Chapter 15: New Avenues respira
Page 752 and 753: Minimal Therapy Models of Transplan
Page 755: CHAPTER 16 SUMMARIES
Page 758 and 759: 724 Chapter 16: Summaries although
Page 760 and 761: 726 Chapter 16: Summaries use of po
Page 762 and 763: 728 Chapter 16: Summaries Table 1.
Page 770 and 771: 736 Chapter 16: Summaries IL-15. Th
Page 772 and 773: 738 Chapter 16: Summaries Patterns
Page 774 and 775: 740 List of Participants Thomas L.
Page 776 and 777: 742 List of Participants Sergio A.
Page 778 and 779: 744 List of Participants Hans Marti
Page 780 and 781: 746 List of Participants David P. S
Page 782 and 783: 748 List of Participants AUTHOR IND
Page 786 and 787: 752 Author Index Stiff, Patrick J.
Page 788 and 789: 754 Key Word Index Hematologic mali
Page 792: ISBN 1-891524-04-6
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