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34 Chapter 1: AML Eric Martin (Medical Center of Delaware), Roger Gingrich (University of Iowa), Matthew Carabasi (University of Alabama), Elizabeth Shpall (University of Colorado), Charles August (University of Miami), Naynash Kamani (University of Miami), Aly Abdel-Mageed (University of Florida), Robert Negrin (Stanford University), and David Freidman (Harris Methodist). REFERENCES 1. Bishop JF: The treatment of adult acute myeloid leukemia. Semin Oncol 24:57-69,1997. 2. Woods WG, Kobrinsky N, Buckley JD, Won Lee J, Sanders J, Neudorf S, Gold S, Barnard DR, DeSwarte J, Dusenberry K, Kalousek D, Arthur DC, Lange BJ: Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: A report from the Children's Cancer Group. Blood 87:4979-4989, 1996. 3. Ravindranath Y, Yeager AM, Chang MN, Steuber CP, Krische.- J, Graham-Pole J, Carroll A, Inoue S, Camitta B, Weinstein HJ: Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. N Engl J Med 334:1428-1434, 1996. 4. Appelbaum FR: Allogeneic hematopoietic stem cell transplantation for acute leukemia. Semin Oncol 24:114-123, 1997. 5. Körbling M, Hunstein W, Fliedner TM, Cayeux S, Dörken B, Fehrentz D, Haas R, Ho AD, Keilholz U, Knauf W, König A, Mende U, Pezzutto A, von Reumont J, Wolf GK, Wannenmacher M, Winkel K, Rother K: Disease-free survival after autologous bone mar row transplantation in patients with acute myelogenous leukemia. Blood 74:1898, 1989. 6. Löwenberg B, Abels J, vanBekkum DW, Dzoljic G, Hagenbeek A, Hendriks WDH, van de Poel J, Sizoo W, Sintnicolaas K, Wagemaker G: Transplantation of non-purified autol ogous bone marrow in patients with AML in first remission. Cancer 54:2840, 1984. 7. McMillan AK, Goldstone AH, Linch DC, Gribben JG, Patterson KG, Richards JDM, Franklin I, Boughton BJ, Milligan DW, Leyland M, Hutchison RM, Newland AC: High- dose chemotherapy and autologous bone marrow transplantation in acute myeloid leukemia. Blood 76:480,1990. 8. Labopin M, Gorin NC: Autologous bone marrow transplantation in 2502 patients with acute leukemia in Europe: A retrospective study. Leukemia 6 (Suppl 4):95, 1992. 9. Chao NJ, Stein AS, Long GD, Negrin RS, Amylon MD, Wong RM, Forman SJ, Blume KG: Busulfan/etoposide: Initial experience with a new preparatory regimen for autolo gous bone marrow transplantation in patients with acute nonlymphoblastic leukemia. Blood 81:319, 1993. 10. Zittoun RA, Mandelli F, Willemze R, de Witte T, Labar B, Resegotti L, Leoni F, Damasio E, Visani G, Papa G, et al.: Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 332:217-223, 1995. 11. Harousseau JL, Cahn JY, Pignon B, Witz F, Milpied N, Delain M, Lioure B, Lamy T, Desablens B, Guilhot F, Caillot D, Abgrall JF, Francois S, Briere J, Guyotat D, Casassus P, Audhuy B, Tellier Z, Hurteloup P, Hervé P: Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute
Ball et al. myeloid leukemia. The Groupe Ouest Est Leucémies Aiguës Myeloblastiques (GOE- LAM). Blood 90:2987-2986,1997. 12. Burnett AK, Goldstone AH, Stevens RMF, Hann IM, Rees JKH, Gray RG, Wheatley K: Randomized comparison of addition of autologous bone-marrow transplantation to inten sive chemotherapy for acute myeloid leukaemia in first remission: Result of MRC AML 10 trial. Lancet 351:700-708, 1998. 13. Yeager AM, Kaizer H, Santos GW, Sarai R, Col vin OM, Stuart RK, Braine HG, Burke PJ, Ambinder RF, Burns WH, Fuller DJ, Davis JM, Karp JE, May WS, Rowley SD, Sensenbrenner LL, Vogelsang GB, Wingard JR: Autologous bone marrow transplanta tion in patients with acute nonlymphocytic leukemia, using ex vivo marrow treatment with 4-hydroperoxycyclophosphamide. N Engl J Med 315:141,1986. 14. Ferrero D, DeFabritiis P, Armadori S, DeFelice L, Gallo E, Meloni G, Pregno P, Pulsoni A, Simone F, Tarella C, Pileri A, Rovera G, Mandelli F: Autologous bone marrow trans plantation in acute myeloid leukemia after in vitro purging with an anti-lacto-n-fucopen- taose III antibody and rabbit complement. Leuk Res 11:265,1987. 15. Rowley SD, Jones RJ, Piantadosi S, Braine HG, Colvin OM, Davis J, Sarai R, Sharkis S, Wingard J, Yeager AM, Santos GW: Efficacy of ex vivo purging for autologous bone mar row transplantation in the treatment of acute nonlymphoblastic leukemia. Blood 74:501, 1989. 16. Gorin NC, Aegerter P, Auvert B, Meloni G, Goldstone AH, Burnett A, Carella A, Korbling M, Hervé P, Maraninchi D, Löwenberg R, Verdonck LF, dePlanque M, Hermans J, Helbig W, Porcellini A, Rizzoli V, Alesandrino EP, Franklin IM, Reiffers J, Colleselli P, Goldman JM: Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: A European survey of the role of marrow purging. Blood 75:1606,1990. 17. Selvaggi KJ, Wilson J, Mills LE, Cornwell III GG, Hurd D, Dodge W, Gingrich R, Martin SE, McMillan R, Miller W, Ball ED: Improved outcome for high risk acute myeloid leukemia patients using autologous bone marrow transplantation and mono clonal antibody purged bone marrow. Blood 83:1698-1705, 1994. 18. Ball ED, Phelps V, Wilson J: Autologous bone marrow transplantation for acute myeloid leukemia in remission or first relapse using monoclonal antibody-purged marrow. In: Dicke KA, Keating A (eds) Autologous Marrow and Blood Transplantation: Proceedings of the Eighth International Symposium. Charlottesville, VA: Carden Jennings, 1997, p. 45-53. 19. Ball ED, Graziano RF, Fanger MW: A unique antigen expressed on myeloid cells and acute leukemia blast cells defined by a monoclonal antibody. J Immunol 130:2937-2941, 1983. • 20. Ball ED, Fanger MW: The expression of myeloid-specific antigens on myeloid leukemia cells: Correlations with leukemia subclasses and implications for normal myeloid differ entiation. Blood 61:456-463,1983. 21. Sabbath KD, Ball ED, Larcom P, Davis RB, Griffin JD: Heterogeneity of clonogenic cells in acute myeloblastic leukemia. J Clin Invest 75:746-753, 1985. 22. Howell AL, Fogg-Leach M, Davis BH, Ball ED: Continuous infusion of complement by an automated cell processor enhances cytotoxicity of monoclonal antibody sensitized leukemia cells. Bone Marrow Transplant 4:317, 1989. 35
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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AUTOLOGOUS BLOOD AND MARROW TRANSPL
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ACKNOWLEDGMENTS We wish to thank Wi
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THE VAN BEKKUM STEM CELL AWARD Prof
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xii Table of Contents CHAPTER 2: AL
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xiv Table of Contents Late Non-Rela
Page 18 and 19: xvi Table of Contents Pretreatment
Page 20 and 21: xviii Table of Contents CHAPTER 7:
Page 22 and 23: XX Table of Contents Long-Term Obse
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Page 27 and 28: 0-9 LIST OF ABBREVIATIONS 2CDA 2-ch
Page 29 and 30: List of Abbreviations xxvii EFS eve
Page 31 and 32: List of Abbreviations MOPP mechlore
Page 33: VOD veno-occlusive disease VPC viru
Page 37 and 38: 4HC-Purged Autologous Stem Cell Tra
Page 39 and 40: 1.0-1 + 0.2 Miller et al. 5 Event F
Page 41 and 42: Miller et al. Adjusted probability
Page 43 and 44: Who Benefits From Autograft in AML
Page 45 and 46: Burnett 11 which to set the transpl
Page 47 and 48: Table 1. Outcome after relapse in M
Page 49 and 50: Immunotherapy in AML: No Positive E
Page 51 and 52: Simonsson et al. inhibit IL-2 induc
Page 53 and 54: Autologous Bone Marrow Transplantat
Page 55 and 56: Ball et al. 21 CD15) and AML-2-23 (
Page 57 and 58: Ball et al. 23 The ex vivo treatmen
Page 59 and 60: Ball et al. 25 Table 2. Factors inv
Page 61 and 62: Ball et al. Overall Survival for Pa
Page 63 and 64: Ball et al. Overall Survival for Pa
Page 65 and 66: Ball et al. 31 Overall Survival for
Page 67: Ball et al. Table 4. Actuarial over
Page 71 and 72: Ball et al. 1993. 38. Mehta J, Powl
Page 73 and 74: Can Autologous Stem Cell Transplant
Page 75 and 76: De Witte et al. 41 novo AML. Auer r
Page 77 and 78: De Witte et al. hematopoietic engra
Page 79 and 80: De Witte et al. 23. Fenaux P, Laï
Page 81 and 82: Stein et al. and fever. No patient
Page 83 and 84: Stein et al. after doses 1, 3, and
Page 85 and 86: Stein et al. early after the transp
Page 87: autologous stem-cell rescue. / Clin
Page 91 and 92: Bone Marrow Transplantation for Acu
Page 93 and 94: Table 2. Autologous BMT in ALL in f
Page 95 and 96: Rowe 61 or adult patients with acut
Page 97 and 98: Hoelzer and Gôkbuget minitransplan
Page 99 and 100: Hoelzer and Gdkbuget 65 blood, earl
Page 101 and 102: Table 3. Risk factors for the defin
Page 103 and 104: Hoelzer and Gôkbuget treatment opt
Page 105 and 106: Hoeker and Gökbuget tical sibling
Page 107 and 108: Sierra et al. INTRODUCTION Two-thir
Page 109 and 110: Sierra et al. Table 2. Adverse char
Page 111 and 112: 1,0 0,0 J Sierra et al. 0 20 40 60
Page 113 and 114: Sierra et al. Months Figure 4 < 30,
Page 115 and 116: Sierra et al. No adverse factors (n
Page 117 and 118: 1994. Sierra et al. 83 10. Canals C
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Martin, Atta, and Hoelzer 85 adult
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Martin, Atta, and Hoelzer 87 Single
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100. Martin, Atta, and Hoelzer 89 P
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Martin, Atta, and Hoelzer 91 chromo
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Autologous vs. Unrelated Allogeneic
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Boyer and Yeager 95 outcomes after
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Boyer and Y eager 97 Table 2. Hypot
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Boyer and Y eager SUMMARY Most of t
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CHAPTER 3 CML
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Autograft Followed by Allograft Wit
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106 Chapter 3: CML (one low-grade a
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108 Chapter 3: CML DISCUSSION Myelo
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110 Chapter 3: CML Philadelphia-neg
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The Case for Manipulation of CML Au
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Toward a Cure by Drug Treatment? Th
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116 Chapter 3 :CML Table 1. Prolong
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118 Chapter 3: CML Table 3. German
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120 Chapter 3: CML Table 5. Normal
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122 Chapter 3: CML Table 8. Surviva
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124 Chapter 3: CML 88:3118-3122, 19
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126 Chapter 3: CML RK, Klingemann H
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The Tyrphostin AG957 Inhibits the I
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130 Chapter 3: CML mobilization. Al
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132 Chapter 3: CML A B 100 n 0 1 5
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134 Chapter 3: CML The in vitro sel
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136 Chapter 3: CML detecting leukem
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Progressive Hodglcin's Lymphoma Fol
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Reece et al. survival is observed i
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0.2 -I 0.0 0 Reece et al. 143 ii i
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Reece et al. Table 3. Causes of non
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Reece et al. carmustine, etoposide
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CD34 + Selection of Hematopoietic B
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Lazarus et al. 151 significantly de
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Lazarus et al. 153 (Sigma, St Louis
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Lazarus et al. 155 Table 2. Effect
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Lazarus et al. 157 difference. Furt
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Lazarus et al. 159 cells after myel
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The European CUP/UP Trial: A Prelim
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Table 1. Patient characteristics at
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Schouten et al. licular non-Hodgkin
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Sweetenham et al. vs. autologous pe
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Table 1. Patient characteristics, g
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Table 2. Patient characteristics, g
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Table 3. Sites of relapse, group A
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Table 4. Patterns of relapse, group
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A 100 80 %OS 60 40 20 B 100 %OS | S
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Sweetenham et al. new sites, and fi
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Sweetenham et al. Treatment options
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Molecular Remission: A Worthwhile A
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Early or Late Autotransplant in Hig
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Schenkein et al. 187 PATIENTS AND M
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Schenkein et al. 189 Toxicity Toxic
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Schenkein et al. 191 16. Glick JH,
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Santini et al. 193 to evaluate the
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Table 1. Continued Santini et al. 1
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Santini et al. 197 cytosine arabino
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1 0 0 1 90- 80- 70- (0 u. 60' o so-
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Hodgkin's lymphoma. N EnglJ Med 333
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CHAPTER 5 MYELOMA
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206 Chapter 5: Myeloma independent
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208 Chapter 5: Myeloma disease (MRD
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210 Chapter 5: Myeloma Scandinavia,
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212 Chapter 5: Myeloma (0 n o B co
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214 Chapter 5: Myeloma B cq d ? o c
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216 Chapter 5: Myeloma patients wit
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218 Chapter 5: Myeloma PBSC transpl
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220 Chapter 5: Myeloma 25. Seiden M
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Autologous Transplantation in Multi
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224 Chapter 5: Myeloma 0 52 44 U §
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226 Chapter 5: Myeloma BM ^ (CD34±
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228 Chapter 5: Myeloma IFM 94 : OS
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230 Chapter 5: Myeloma two groups a
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232 Chapter 5: Myeloma increase bot
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234 Chapter 5: Myeloma REFERENCES 1
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236 Chapter 5: Myeloma Intensified
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238 Chapter 5: Myeloma of CD34 + ce
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Chapter 5: Myeloma Table 2. Descrip
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242 Chapter 5: Myeloma o 8H 0 2 4 6
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244 Chapter 5: Myeloma ated with sh
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The Presence of Micrometastases in
Page 283 and 284:
Kvalheim et al. 249 Table 1. Immuno
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Kvalheim et al. 251 Figure 1. Sixty
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Kvalheim et al. 253 DISCUSSION In t
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Kvalheim et al. 255 Bastert G: Micr
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Hood et al. 257 In an effort to inc
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#CD34 + cells in blood = Hood et al
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Hood et al. 261 Table 3. Frequency
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Hood et al. 263 REFERENCES 1. Rill
Page 299 and 300:
The Clinical Significance of Breast
Page 301 and 302:
Moss et al. tests, and bilateral po
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Moss et al. 269 0 15 70 143 200 400
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Moss et al. 271 0 3 6 12 18 24 30 3
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Moss et al. 273 8. Passos-Coelho J,
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Autotransplantation for Men With Br
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McCarthy et al. 277 radiation, two
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High Dose Sequential Chemotherapy W
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Viens et al. 281 3 g/m 2 and doxoru
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Table 1. Tumor characteristics Exte
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Table 4. Response Viens et al. 285
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Viens et al. 287 Table 5. Pathologi
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Viens et al. 289 apy for inoperable
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Gliick et al. 291 INTRODUCTION The
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Gluck et al. 293 RESULTS Patient de
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Glück et al. 295 Table 3. Response
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Gluck et al. 297 Overall Survival O
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Gluck et al. 299 Sudbury patients w
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Gluck et al. 301 anthracycline or t
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Repetitive High-Dose Therapy With P
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Prince et al. paramagnetic separati
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Prince et al. Table 1. High-dose re
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Table 2. Patient characteristics (n
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Table 4. Hematopoietic recovery fol
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1.0- M C .S 0.8- a c *fe o o> 0.6-
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M 1.0 I 0.8H s? VI o.6H S 0.2 0.0 P
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a Prince et al. days to platelets >
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Table 5. Results of Isolex 300i CD3
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Prince et al. 321 Figure 5, continu
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Prince et al. 323 months after tran
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Prince et al. 325 excessive to be u
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Prince et al. 327 eight patients ha
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Prince et al. 329 marrow transplant
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Prince et al. intensive chemotherap
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-Q CO .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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.Q CD .Q O 1.0 0.9 0.8 0.7 0.6 0.5
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oba Q. 1.0 0.9 Dicke et al. Stage I
Page 373 and 374:
Vahdat with peripheral blood progen
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Evaluation of Prognostic Factors fo
Page 377 and 378:
Fields et al. 343 PATIENTS AND METH
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Table 1. Chemotherapy regimens. Fie
Page 381 and 382:
Fields et al. Stage II; 4-9 Pos LN
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U U Fields et al.
Page 385 and 386:
Fields et al. 351 between 1 and 2 y
Page 387 and 388:
European Trends and the EBMT Databa
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25% % 22% / 17% \ Rosti et al. 355
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Rosti et al. 357 The new Italian St
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Rosti et al. 6. Haas R, Schmid H, H
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Bewick et al. 363 INTRODUCTION The
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Bewick et al. 365 Blood samples obt
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Bewick et al. 367 HDCT with ABSC su
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Bewick et al. Progression Free Surv
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Bewick et al. pression in MBC, i.e.
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Bewick et al. 14. Kandl HL, Seymour
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CHAPTER 7 OTHER SOLID TUMORS
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378 Chapter 7: Solid Tumors INTRODU
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380 Chapter 7: Solid Tumors Prepara
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382 Chapter 7: Solid Tumors Surviva
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384 Chapter 7: Solid Tumors months
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386 Chapter 7: Solid Tumors have be
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High-Dose Chemotherapy in the Manag
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390 Chapter 7: Solid Tumors followe
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392 Chapter 7: Solid Tumors Table 1
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394 Chapter 7: Solid Tumors (mucosi
Page 430 and 431:
Three-Fold Intensification by Seque
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Page 434 and 435:
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High-Dose Therapy for Small Cell Lu
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404 Chapter 7: Solid Tumors chemoth
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406 Chapter 7: Solid Tumors SCLC ha
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408 Chapter 7: Solid Tumors relapse
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410 Chapter 7: Solid Tumors 69:585-
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412 Chapter 7: Solid Tumors ogous b
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414 Chapter 7: Solid Tumors 64. Bru
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416 Chapter 7: Solid Tumors Prignot
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418 Chapter 7: Solid Tumors CO > CO
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420 Chapter 7: Solid Tumors TANDEM
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Multiple Courses of Cyclophosphamid
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424 Chapter 7: Solid Tumors and the
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426 Chapter 7: Solid Tumors Thiotep
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430 Chapter 7: Solid Tumors E 100 0
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432 Chapter 7: Solid Tumors course
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434 Chapter 7: Solid Tumors boplati
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436 Chapter 7: Solid Tumors INTRODU
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438 - Chapter 7: Solid Tumors Table
Page 474 and 475:
440 Chapter 7: Solid Tumors seeded
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442 Chapter 7: Solid Tumors DISCUSS
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444 Chapter 7: Solid Tumors 10. Di
Page 480 and 481:
446 Chapter 7: Solid Tumors plasma
Page 483 and 484:
Autologous Stem Cell Transplantatio
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Keystone 451 hypertension, anemia,
Page 487 and 488:
Fassas et al. 453 INTRODUCTION Mult
Page 489 and 490:
Fassas et al. Table 2. Stem cell mo
Page 491 and 492:
Table 3. Toxicity after stem cell i
Page 493 and 494:
Fassas et al. Table 5. Trial 1: cha
Page 495 and 496:
Fassas et al. MS PROGRESSION FREE S
Page 497 and 498:
Fassas et al. ic or autologous bone
Page 499 and 500:
1 2 1 6 EAE. Burt et al. 465 Becaus
Page 501 and 502:
Burt et al. Since cyclophosphamide
Page 503 and 504:
Burt et al. 469 toxicity study, we
Page 505 and 506:
Burt et dl. All 23. Mor F, Cohen IR
Page 507 and 508:
Hasler, Gratwohl, and Tyndall an ev
Page 509 and 510:
Hasler, Gratwohl, and Tyndall 475 B
Page 511 and 512:
Kuis, Wulffraat, and Sanders 477 st
Page 513 and 514:
Kuis, Wulffraat, and Sanders neousl
Page 515:
CHAPTER 9 LONG-TERM EFFECTS
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484 Chapter 9: Long-Term Effects po
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486 Chapter 9: Long-Term Effects Ta
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488 Chapter 9: Long-Term Effects ml
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490 Chapter 9: Long-Term Effects 4.
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492 Chapter 9: Long-Term Effects us
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494 Chapter 9: Long-Term Effects AB
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Page 532 and 533:
498 Chapter 9: Long-Term Effects En
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500 Chapter 9: Long-Term Effects Rl
Page 536 and 537:
502 Chapter 9: Long-Term Effects RE
Page 538 and 539:
504 Chapter 9: Long-Term Effects A,
Page 540 and 541:
Long-Term Follow-Up of Autologous T
Page 542 and 543:
Page 545:
CHAPTER 10 GRAFT MANIPULATION
Page 548 and 549:
514 Chapter 10: Graft Manipulation
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Stem Cell Reinfusion Over Two Conse
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Final Report of the First Prospecti
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Page 635 and 636:
Canine Hematopoietic Stem Allograft
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Sandmaier et al. 603 The resultant
Page 639 and 640:
Sandmaier et al. 605 synthesis path
Page 641 and 642:
Sandmaier et al. 607 interactions o
Page 643 and 644:
Sandmaier et al. 1991. 2. Burchenal
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87:3508-3513,1996. Sandmaier et al.
Page 647 and 648:
Giralt, Khouri, and Champlin Table
Page 649 and 650:
Giralt, Khouri, and Champlin seven
Page 651 and 652:
1.0 3 0.2 Giralt, Khouri, and Champ
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CHAPTER 12 GENE THERAPY
Page 656 and 657:
622 Chapter 12: Gene Therapy INTROD
Page 658 and 659:
624 Chapter 12: Gene Therapy RESULT
Page 660 and 661:
626 Chapter 12: Gene Therapy envisi
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628 Chapter 12: Gene Therapy cer in
Page 664 and 665:
A Vaccine of Melanoma Peptide Loade
Page 667 and 668:
B43(anti-CD 19)-Gen i stein Immunot
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Targeting Immunotherapy for the Tre
Page 671 and 672:
McGuinness andArceci 637 modified m
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McGuinness andArceci 639 leukemic c
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McGuinness and Arced 641 in G418. T
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McGuinness andArceci 643 Figure 2
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mRNA for hB7-1 (1491 bp) mRNA for C
Page 681 and 682:
McGuinness and Arced CD80PE C080PE
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McGuinness andArceci 649 8. Robert
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McGuinness andArceci immune respons
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McGuinness andArceci 75. Jubinsky F
Page 689 and 690:
Slavin et al. 655 up suggests, as p
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Slavin et al. 657 was a phase lib c
Page 693 and 694:
Slavin et al. presented, appears to
Page 695 and 696:
Antitumor Immunotherapy in Autologo
Page 697 and 698:
Klingemann et al. 663 Table 3. Meth
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CHAPTER 14 RADIOIMMUNOTHERAPY
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668 Chapter 14: Radioimmunotherapy
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Page 710 and 711:
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Page 714 and 715:
Selection of Radioisotopes, Chelate
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Page 726 and 727:
Radioimmunotherapy of Common Epithe
Page 729:
CHAPTER 15 NEW AVENUES
Page 732 and 733:
698 Chapter 15: New Avenues Table 1
Page 734 and 735:
700 Chapter 15: New Avenues An alte
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702 Chapter 15: New Avenues who can
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704 Chapter 15: New Avenues myeloid
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706 Chapter 15: New Avenues 48. Gir
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Emerging Viral Infections in Blood
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710 Chapter 15: New Avenues influen
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712 Chapter 15: New Avenues Among a
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714 Chapter 15: New Avenues physica
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716 Chapter 15: New Avenues respira
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Minimal Therapy Models of Transplan
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CHAPTER 16 SUMMARIES
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724 Chapter 16: Summaries although
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726 Chapter 16: Summaries use of po
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728 Chapter 16: Summaries Table 1.
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Page 768 and 769:
Page 770 and 771:
736 Chapter 16: Summaries IL-15. Th
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738 Chapter 16: Summaries Patterns
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740 List of Participants Thomas L.
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742 List of Participants Sergio A.
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744 List of Participants Hans Marti
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746 List of Participants David P. S
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748 List of Participants AUTHOR IND
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750 Author Index Hurd, D.D. 483 Kui
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752 Author Index Stiff, Patrick J.
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754 Key Word Index Hematologic mali
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ISBN 1-891524-04-6
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